MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Cleavage and polyadenylation specificity factor subunit 2; AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit; Short=CPSF 100 kDa subunit; |
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| MyHits synonyms | CPSF2_BOVIN , Q10568 , 0934519C6A73C2A3 |
 Legends: 1, Phosphoserine. {ECO:0000250|UniProtKB:Q9P2I0}; 2, ipfam:RMMBL [T]; 3, ipfam:Beta-Casp [T]; 4, ismart:Beta-Casp [T].
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ID CPSF2_BOVIN Reviewed; 782 AA.
AC Q10568;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 30-NOV-2016, entry version 105.
DE RecName: Full=Cleavage and polyadenylation specificity factor subunit 2;
DE AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit;
DE Short=CPSF 100 kDa subunit;
GN Name=CPSF2; Synonyms=CPSF100;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Thymus;
RX PubMed=7969155; DOI=10.1128/MCB.14.12.8183;
RA Jenny A., Hauri H.-P., Keller W.;
RT "Characterization of cleavage and polyadenylation specificity factor
RT and cloning of its 100-kilodalton subunit.";
RL Mol. Cell. Biol. 14:8183-8190(1994).
RN [2]
RP SEQUENCE REVISION.
RA Jenny A.;
RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the cleavage and polyadenylation
CC specificity factor (CPSF) complex that play a key role in pre-mRNA
CC 3'-end formation, recognizing the AAUAAA signal sequence and
CC interacting with poly(A) polymerase and other factors to bring
CC about cleavage and poly(A) addition. Involved in the histone 3'
CC end pre-mRNA processing (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the cleavage and polyadenylation specificity
CC factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and
CC FIP1L1. Interacts with CPSF3, CSTF2 and SYMPK. Interacts with
CC ZC3H3. {ECO:0000250|UniProtKB:O35218,
CC ECO:0000250|UniProtKB:Q9P2I0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1
CC subfamily. {ECO:0000305}.
DR EMBL; X75931; CAA53535.1; -; mRNA.
DR PIR; A56351; A56351.
DR RefSeq; NP_787002.1; NM_175808.2.
DR RefSeq; XP_005222184.1; XM_005222127.3.
DR UniGene; Bt.4077; -.
DR ProteinModelPortal; Q10568; -.
DR IntAct; Q10568; 1.
DR STRING; 9913.ENSBTAP00000013500; -.
DR PaxDb; Q10568; -.
DR PRIDE; Q10568; -.
DR Ensembl; ENSBTAT00000013500; ENSBTAP00000013500; ENSBTAG00000010227.
DR GeneID; 327689; -.
DR KEGG; bta:327689; -.
DR CTD; 53981; -.
DR eggNOG; KOG1135; Eukaryota.
DR eggNOG; COG1236; LUCA.
DR GeneTree; ENSGT00860000133746; -.
DR HOGENOM; HOG000264343; -.
DR HOVERGEN; HBG051106; -.
DR InParanoid; Q10568; -.
DR KO; K14402; -.
DR OMA; LMRNNIN; -.
DR OrthoDB; EOG091G03GG; -.
DR TreeFam; TF106131; -.
DR Reactome; R-BTA-109688; Cleavage of Growing Transcript in the Termination Region.
DR Reactome; R-BTA-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-BTA-72187; mRNA 3'-end processing.
DR Reactome; R-BTA-77595; Processing of Intronless Pre-mRNAs.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000010227; -.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006398; P:mRNA 3'-end processing by stem-loop binding and cleavage; ISS:UniProtKB.
DR GO; GO:0006379; P:mRNA cleavage; IEA:InterPro.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR Gene3D; 3.60.15.10; -; 3.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR027075; CPSF2.
DR InterPro; IPR025069; Cpsf2_C.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR11203:SF5; PTHR11203:SF5; 2.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF13299; CPSF100_C; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; SSF56281; 2.
PE 1: Evidence at protein level;
KW Complete proteome; Direct protein sequencing; mRNA processing;
KW Nucleus; Phosphoprotein; Reference proteome; RNA-binding.
FT CHAIN 1 782 Cleavage and polyadenylation specificity
FT factor subunit 2.
FT /FTId=PRO_0000074392.
FT MOD_RES 419 419 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q9P2I0}.
FT MOD_RES 420 420 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q9P2I0}.
FT MOD_RES 423 423 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q9P2I0}.
FT MOD_RES 660 660 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q9P2I0}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 529 591 ipfam:RMMBL [T]
FT MYHIT 243 367 ipfam:Beta-Casp [T]
FT MYHIT 17 223 ismart:Lactamase_B [T]
FT MYHIT 608 779 ipfam:CPSF100_C [T]
FT MYHIT 243 368 ismart:Beta-Casp [T]
FT MYHIT 22 197 ipfam:Lactamase_B_6 [T]
SQ SEQUENCE 782 AA; 88417 MW; 0934519C6A73C2A3 CRC64;
MTSIIKLTTL SGVQEESALC YLLQVDEFRF LLDCGWDEHF SMDIIDSLRK HVHQIDAVLL
SHPDPLHLGA LPYAVGKLGL NCAIYATIPV YKMGQMFMYD LYQSRHNTED FTLFTLDDVD
AAFDKIQQLK FSQIVNLKGK GHGLSITPLP AGHMIGGTIW KIVKDGEEEI VYAVDFNHKR
EIHLNGCSLE MLSRPSLLIT DSFNATYVQP RRKQRDEQLL TNVLETLRGD GNVLIAVDTA
GRVLELAQLL DQIWRTKDAG LGVYSLALLN NVSYNVVEFS KSQVEWMSDK LMRCFEDKRN
NPFQFRHLSL CHGLSDLARV PSPKVVLASQ PDLECGFSRD LFIQWCQDPK NSIILTYRTT
PGTLARFLID NPSEKVTEIE LRKRVKLEGK ELEEYLEKEK LKKEAAKKLE QSKEADIDSS
DESDAEEDID QPSAHKTKHD LMMKGEGSRK GSFFKQAKKS YPMFPAPEER IKWDEYGEII
KPEDFLVPEL QATEEEKSKL ESGLTNGDEP MDQDLSDVPT KCISTTESIE IKARVTYIDY
EGRSDGDSIK KIINQMKPRQ LIIVHGPPEA SQDLAECCRA FGGKDIKVYM PKLHETVDAT
SETHIYQVRL KDSLVSSLQF CKAKDAELAW IDGVLDMRVS KVDTGVILEE GELKDDGEDS
EMQVDAPSDS SVIAQQKAMK SLFGDDEKET GEESEIIPTL EPLPPHEVPG HQSVFMNEPR
LSDFKQVLLR EGIQAEFVGG VLVCNNQVAV RRTETGRIGL EGCLCQDFYR IRDLLYEQYA
IV
//
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