MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Copine-3 {ECO:0000305}; AltName: Full=Copine III {ECO:0000250|UniProtKB:O75131}; |
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| MyHits synonyms | CPNE3_PONAB , Q5RAE1 , 7EF0448F9B15D362 |
 Legends: 1, Phosphoserine. {ECO:0000250|UniProtKB:O75131}; 2, C2 1. {ECO:0000255|PROSITE- ProRule:PRU00041}; 3, C2 2. {ECO:0000255|PROSITE- ProRule:PRU00041}.
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ID CPNE3_PONAB Reviewed; 537 AA.
AC Q5RAE1;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 30-NOV-2016, entry version 51.
DE RecName: Full=Copine-3 {ECO:0000305};
DE AltName: Full=Copine III {ECO:0000250|UniProtKB:O75131};
GN Name=CPNE3 {ECO:0000250|UniProtKB:O75131};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Calcium-dependent phospholipid-binding protein that
CC plays a role in ERBB2-mediated tumor cell migration in response to
CC growth factor heregulin stimulation.
CC {ECO:0000250|UniProtKB:O75131}.
CC -!- SUBUNIT: Monomer. Interacts with ERBB2 (preferentially with the
CC tyrosine phosphorylated form); this interaction occurs at the cell
CC membrane and is increased in a growth factor heregulin-dependent
CC manner. Interacts with SHC1; this interaction may mediate the
CC binding of CPNE3 with ERBB2. Interacts with RACK1.
CC {ECO:0000250|UniProtKB:O75131}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75131}.
CC Cytoplasm {ECO:0000250|UniProtKB:O75131}. Cell membrane
CC {ECO:0000250|UniProtKB:O75131}. Cell junction
CC {ECO:0000250|UniProtKB:O75131}. Cell junction, focal adhesion
CC {ECO:0000250|UniProtKB:O75131}. Note=Associates to the membrane in
CC a calcium-dependent manner. Translocates to the cell membrane and
CC the nucleus in a calcium- or growth factor heregulin-dependent
CC manner. Colocalizes with the tyrosine phosphorylated ERBB2 form at
CC cell membrane and focal adhesions in a calcium- or growth factor
CC heregulin-dependent manner. {ECO:0000250|UniProtKB:O75131}.
CC -!- PTM: Phosphorylated on serine and threonine residues.
CC {ECO:0000250|UniProtKB:O75131}.
CC -!- SIMILARITY: Belongs to the copine family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 2 C2 domains. {ECO:0000255|PROSITE-
CC ProRule:PRU00041}.
CC -!- SIMILARITY: Contains 1 VWFA domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00219}.
DR EMBL; CR859076; CAH91269.1; -; mRNA.
DR RefSeq; NP_001127397.1; NM_001133925.1.
DR ProteinModelPortal; Q5RAE1; -.
DR STRING; 9601.ENSPPYP00000021004; -.
DR GeneID; 100174464; -.
DR KEGG; pon:100174464; -.
DR CTD; 8895; -.
DR eggNOG; KOG1327; Eukaryota.
DR eggNOG; ENOG410XPC8; LUCA.
DR HOVERGEN; HBG066841; -.
DR InParanoid; Q5RAE1; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0030054; C:cell junction; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005925; C:focal adhesion; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; ISS:UniProtKB.
DR GO; GO:0048306; F:calcium-dependent protein binding; ISS:UniProtKB.
DR GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR GO; GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB.
DR GO; GO:0038128; P:ERBB2 signaling pathway; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR CDD; cd01459; vWA_copine_like; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR010734; Copine.
DR InterPro; IPR002035; VWF_A.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF07002; Copine; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49562; SSF49562; 2.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50004; C2; 2.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Complete proteome; Cytoplasm; Membrane;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1 537 Copine-3.
FT /FTId=PRO_0000144840.
FT DOMAIN 2 99 C2 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00041}.
FT DOMAIN 125 230 C2 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00041}.
FT DOMAIN 291 513 VWFA. {ECO:0000255|PROSITE-
FT ProRule:PRU00219}.
FT MOD_RES 14 14 Phosphoserine.
FT {ECO:0000250|UniProtKB:O75131}.
FT MOD_RES 197 197 Phosphoserine.
FT {ECO:0000250|UniProtKB:O75131}.
FT MOD_RES 243 243 Phosphoserine.
FT {ECO:0000250|UniProtKB:O75131}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 13 112 ipfam:C2 [T]
FT MYHIT 1 99 iprf:C2 [T]
FT MYHIT 145 239 ipfam:C2 [T]
FT MYHIT 310 524 ipfam:Copine [T]
FT MYHIT 7 114 ismart:C2 [T]
FT MYHIT 289 495 ismart:VWA [T]
FT MYHIT 139 245 ismart:C2 [T]
FT MYHIT 138 230 iprf:C2 [T]
SQ SEQUENCE 537 AA; 60102 MW; 7EF0448F9B15D362 CRC64;
MAAQCVTKVA LNVSCANLLD KDIGSKSDPL CVLFLNTSGQ QWYEVERTER IKNCLNPQFS
KTFIIDYYFE VVQKLKFGVY DIDNKTIELS DDDFLGECEC TLGQVVSSKK LTRPLVMKNG
RPAGKGSITI SAEEIKDNRV VLFEMEARKP DNKDLFGKSD PYLEFHKQTS DGNWLMVHRT
EVVKNNLNPV WRPFKISLNS LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS
RCSPVEFECI NEKKRQKKKS YKNSGVISVK QCEITVECTF LDYIMGGCQL NFTVGVDFTG
SNDDPRSPDS LHYISPNGVN EYLTALWSVG LVIQDYDADK MFPAFGFGAQ IPPQWQVSHE
FPMNFNPSNP YCNGIQGIVE AYRSCLPQIK LYGPTNFSPI INHVARFAAA AAQQQTASQY
FVLLIITDGV ITDLDETRQA IVNASRLPMS IIIVGVGGAD FSAMEFLDGD GGGLRSPSGE
VAIRDIVQFV PFRQFQNAPK EALAQCVLAE IPQQVVGYFN TYKLLPPKNP ATKQQKQ
//
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