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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionRecName: Full=Putative cytochrome P450 139; EC=1.14.-.-;
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MyHits synonymsCP139_MYCTU , P9WPM1 , D0EW72 , F2GKM3 , O86330 , P63719 , DCBA4CF08FAD1A94
match map segment
ipfam:p450 ipat:CYTOCHROME_P450  
Legends: 1, Iron (heme axial ligand). {ECO:0000250}; 2, ipat:CYTOCHROME_P450 [T]. 
ID   CP139_MYCTU             Reviewed;         430 AA.
AC   P9WPM1; D0EW72; F2GKM3; O86330; P63719;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   02-NOV-2016, entry version 22.
DE   RecName: Full=Putative cytochrome P450 139;
DE            EC=1.14.-.-;
GN   Name=cyp139; OrderedLocusNames=Rv1666c; ORFNames=MTV047.02c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Vasilevskaya A.V., Alyapkina Y.S., Usanov S.A.;
RT   "Polymorphism of cytochrome P450 of drug resistant form of
RT   Mycobacterium tuberculosis.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA   Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA   Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA   Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA   Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA   Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA   Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the
RT   complete genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
RA   Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
RA   Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
RA   Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
RA   Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high
RT   resolution mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
DR   EMBL; GQ900520; ACX47919.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44431.1; -; Genomic_DNA.
DR   PIR; D70985; D70985.
DR   RefSeq; NP_216182.1; NC_000962.3.
DR   RefSeq; WP_003901231.1; NC_000962.3.
DR   ProteinModelPortal; P9WPM1; -.
DR   STRING; 83332.Rv1666c; -.
DR   PaxDb; P9WPM1; -.
DR   EnsemblBacteria; CCP44431; CCP44431; Rv1666c.
DR   GeneID; 885528; -.
DR   KEGG; mtu:Rv1666c; -.
DR   KEGG; mtv:RVBD_1666c; -.
DR   TubercuList; Rv1666c; -.
DR   eggNOG; ENOG4105JZI; Bacteria.
DR   eggNOG; COG2124; LUCA.
DR   OMA; RINAPAW; -.
DR   PhylomeDB; P9WPM1; -.
DR   BioCyc; MTBH37RV:G185E-5856-MONOMER; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005618; C:cell wall; IDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00465; EP450IV.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Heme; Iron; Metal-binding; Monooxygenase;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN         1    430       Putative cytochrome P450 139.
FT                                /FTId=PRO_0000052300.
FT   METAL       372    372       Iron (heme axial ligand). {ECO:0000250}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        16    403       ipfam:p450 [T]
FT   MYHIT       365    374       ipat:CYTOCHROME_P450 [T]
SQ   SEQUENCE   430 AA;  47865 MW;  DCBA4CF08FAD1A94 CRC64;
     MRYPLGEALL ALYRWRGPLI NAGVGGHGYT YLLGAEANRF VFANADAFSW SQTFESLVPV
     DGPTALIVSD GADHRRRRSV VAPGLRHHHV QRYVATMVSN IDTVIDGWQP GQRLDIYQEL
     RSAVRRSTAE SLFGQRLAVH SDFLGEQLQP LLDLTRRPPQ VMRLQQRVNS PGWRRAMAAR
     KRIDDLIDAQ IADARTAPRP DDHMLTTLIS GCSEEGTTLS DNEIRDSIVS LITAGYETTS
     GALAWAIYAL LTVPGTWESA ASEVARVLGG RVPAADDLSA LTYLNGVVHE TLRLYSPGVI
     SARRVLRDLW FDGHRIRAGR LLIFSAYVTH RLPEIWPEPT EFRPLRWDPN AADYRKPAPH
     EFIPFSGGLH RCIGAVMATT EMTVILARLV ARAMLQLPAQ RTHRIRAANF AALRPWPGLT
     VEIRKSAPAQ
//