Entry sw:CP100_MOUSE

ID   CP100_MOUSE             Reviewed;         613 AA.
AC   Q80VN0; E9PYA2; Q6AXD6;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 2.
DT   02-NOV-2016, entry version 81.
DE   RecName: Full=Cilia- and flagella-associated protein 100 {ECO:0000305};
DE   AltName: Full=Coiled-coil domain-containing protein 37 {ECO:0000250|UniProtKB:Q494V2};
GN   Name=Cfap100 {ECO:0000312|MGI:MGI:2141635};
GN   Synonyms=Ccdc37 {ECO:0000312|MGI:MGI:2141635};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-613.
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH79632.1}, and
RC   Olfactory epithelium {ECO:0000312|EMBL:AAH47211.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in ciliary/flagellar motility by
CC       regulating the assembly and the activity of axonemal inner dynein
CC       arm. {ECO:0000250|UniProtKB:A8I4E9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A8I4E9}.
CC   -!- SIMILARITY: Belongs to the CFAP100 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH47211.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC       Sequence=AAH47211.1; Type=Miscellaneous discrepancy; Note=Intron retention, and aberrant splicing.; Evidence={ECO:0000305};
CC       Sequence=AAH79632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC       Sequence=AAH79632.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
DR   EMBL; AC163346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC047211; AAH47211.1; ALT_SEQ; mRNA.
DR   EMBL; BC079632; AAH79632.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS51849.1; -.
DR   RefSeq; NP_776136.2; NM_173775.3.
DR   UniGene; Mm.386876; -.
DR   ProteinModelPortal; Q80VN0; -.
DR   SMR; Q80VN0; -.
DR   STRING; 10090.ENSMUSP00000126515; -.
DR   iPTMnet; Q80VN0; -.
DR   PhosphoSitePlus; Q80VN0; -.
DR   PaxDb; Q80VN0; -.
DR   PRIDE; Q80VN0; -.
DR   Ensembl; ENSMUST00000165673; ENSMUSP00000126515; ENSMUSG00000048794.
DR   GeneID; 243538; -.
DR   KEGG; mmu:243538; -.
DR   UCSC; uc009cxg.2; mouse.
DR   UCSC; uc012eoz.1; mouse.
DR   CTD; 348807; -.
DR   MGI; MGI:2141635; Cfap100.
DR   eggNOG; ENOG410IFH9; Eukaryota.
DR   eggNOG; ENOG410YEAI; LUCA.
DR   GeneTree; ENSGT00530000063831; -.
DR   HOGENOM; HOG000007134; -.
DR   HOVERGEN; HBG081040; -.
DR   InParanoid; Q80VN0; -.
DR   OMA; SPKEWLE; -.
DR   OrthoDB; EOG091G05I3; -.
DR   ChiTaRS; Ccdc37; mouse.
DR   PRO; PR:Q80VN0; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000048794; -.
DR   CleanEx; MM_CCDC37; -.
DR   ExpressionAtlas; Q80VN0; baseline and differential.
DR   GO; GO:0097545; C:axonemal outer doublet; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; ISS:UniProtKB.
DR   GO; GO:2000574; P:regulation of microtubule motor activity; ISS:UniProtKB.
DR   InterPro; IPR025252; DUF4200.
DR   Pfam; PF13863; DUF4200; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN         1    613       Cilia- and flagella-associated protein
FT                                100.
FT                                /FTId=PRO_0000234489.
FT   COILED      167    198       {ECO:0000255}.
FT   COILED      233    260       {ECO:0000255}.
FT   COILED      396    435       {ECO:0000255}.
FT   COILED      504    580       {ECO:0000255}.
FT   CONFLICT    535    535       E -> V (in Ref. 2; AAH79632).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       154    272       ipfam:DUF4200 [T]
SQ   SEQUENCE   613 AA;  72033 MW;  DB57C2D27F68E6B3 CRC64;
     MAFKARSSRF SVKMVEDTGG SQDLINNSFS SFIEEKSKES KKNKGNVTIS DRSSNPFHIS
     RDMDYFLLRE QEQNQAIAER EQKKILRVHQ KMTYASKVSA KHTSLRRELQ LEDEMEQQLL
     NAEAKEMNCF RENNDWKLAM TRERKREPET LNDYMEKRRS MFLLQYALAM KRNEIQRLEM
     LATREENRLE RAEKFLEKDA SLFDEFLREN DRNSVQAMRM AEKETKIKTE KIVEIRELTA
     QITSIKSEIS KFEDTLKHYK IYKEFLYKLS PKEWLDEQQE KHLAFKRAKE SSELTRNNST
     AILFGDKGSG SKSKTAFLWK EVPGLKKVTK TGRLVKALSS SIQSLPQVGQ LTQLSPHSEL
     DSRLSSTMFP SQDDTDSDGE ELALYFTEPQ QLLDVFTKLE EENLSLIQNT QEMEETLDEL
     NVTLKNTQIR MDKEVNLLKQ WIASMMISIS KEEESAAELE LKARVFHFGE YQGDQQDTML
     ESLNHKVLEV YRKCVGMQQE ANLGTVQMLT VVERQLDELL ENLERVPQVK IEQAEKAKER
     ERRMRLREEK AMMQKQLQEE RLQRARARAQ AKIKKKRGRK LISRSHPPVI KVKEVREQTL
     INKDKEEMLF FFT
//