Entry sw:CP100_MACFA

ID   CP100_MACFA             Reviewed;         608 AA.
AC   Q4R8V8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   02-NOV-2016, entry version 21.
DE   RecName: Full=Cilia- and flagella-associated protein 100 {ECO:0000305};
DE   AltName: Full=Coiled-coil domain-containing protein 37 {ECO:0000250|UniProtKB:Q494V2};
GN   Name=CFAP100 {ECO:0000250|UniProtKB:Q494V2};
GN   Synonyms=CCDC37 {ECO:0000250|UniProtKB:Q494V2};
GN   ORFNames=QtsA-11340 {ECO:0000312|EMBL:BAE00463.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in ciliary/flagellar motility by
CC       regulating the assembly and the activity of axonemal inner dynein
CC       arm. {ECO:0000250|UniProtKB:A8I4E9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A8I4E9}.
CC   -!- SIMILARITY: Belongs to the CFAP100 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE00463.1; Type=Erroneous termination; Positions=555; Note=Translated as Glu.; Evidence={ECO:0000305};
CC       Sequence=BAE00463.1; Type=Frameshift; Positions=42; Evidence={ECO:0000305};
DR   EMBL; AB168339; BAE00463.1; ALT_SEQ; mRNA.
DR   UniGene; Mfa.6772; -.
DR   HOVERGEN; HBG081040; -.
DR   GO; GO:0097545; C:axonemal outer doublet; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; ISS:UniProtKB.
DR   GO; GO:2000574; P:regulation of microtubule motor activity; ISS:UniProtKB.
DR   InterPro; IPR025252; DUF4200.
DR   Pfam; PF13863; DUF4200; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton.
FT   CHAIN         1    608       Cilia- and flagella-associated protein
FT                                100.
FT                                /FTId=PRO_0000234488.
FT   COILED      164    196       {ECO:0000255}.
FT   COILED      230    257       {ECO:0000255}.
FT   COILED      385    435       {ECO:0000255}.
FT   COILED      500    575       {ECO:0000255}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       151    269       ipfam:DUF4200 [T]
SQ   SEQUENCE   608 AA;  70901 MW;  2096C89FADC1FEFF CRC64;
     MSETLSNIVS KNMTNDKNSL ESMNISSSSS AEENPKKQAK KXKERGPDPS ANPFHLSGDV
     DFFLLRDQER NKALSERQQQ KTMRVHEKMT YSSKVLAKHT SLRRQLQLED KQEDLEARTE
     ADHLRAFRDY NTWKLTLTKE KNVEPENMSG YLKQKRQMFL LQYTLDCKRR EIQRLETLAT
     KEEARLQQAE KSLAKDAALF DEFLRENDCS SVQAMKAAEK ETKAKIEKIL EIRDLTTQIV
     NIKSEISRFE DTLQHYKVYK DFLYKLSPKE WLEEQEKKHL FLKNAKEISE ASKDGSVNST
     PGDKGPGIKG KASSVWAKEG QGTKKPWRFL RLGRSLSYLS SPQQGSQPSE SSGGNSRGSN
     SPIPLTQEDT DSDGEEPQLY FTEPQQLLDV FRELEEQNLS LIQNRQEMEE TLEELSRTLK
     HTQIRMDREV NQLKQWVSTM MMSITKEEDT AAELELKARV FHFGEYKGDQ QDKLLESLNW
     KVLDVYRNCI GTQQEANLGT VQMLTIIEHQ LDELLENLER VPQVKIEQAE RAKEKERRIR
     LREEKLQMQK ILQEERLQRA RARAQAEIKK KRGRTLVCRS QPPVHRIKQE SEHTLMDKEK
     EELLFFFT
//