MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Centrosomal protein of 120 kDa; Short=Cep120; AltName: Full=Coiled-coil domain-containing protein 100; |
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| MyHits synonyms | CE120_BOVIN , A0JN62 , 4723C6D958F13E8B |
 Legends: 1, Phosphoserine. {ECO:0000250|UniProtKB:Q7TSG1}; 2, VAR_SEQ Missing (in isoform 2). {ECO:0000303|Ref.2}; 3, ipfam:C2 [T].
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ID CE120_BOVIN Reviewed; 987 AA.
AC A0JN62;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 30-NOV-2016, entry version 66.
DE RecName: Full=Centrosomal protein of 120 kDa;
DE Short=Cep120;
DE AltName: Full=Coiled-coil domain-containing protein 100;
GN Name=CEP120; Synonyms=CCDC100;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology
RT and evolution.";
RL Science 324:522-528(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the microtubule-dependent coupling of
CC the nucleus and the centrosome. Involved in the processes that
CC regulate centrosome-mediated interkinetic nuclear migration (INM)
CC of neural progenitors and for proper positioning of neurons during
CC brain development. Also implicated in the migration and
CC selfrenewal of neural progenitors. May play a role in centriole
CC duplication during mitosis (By similarity).
CC {ECO:0000250|UniProtKB:Q7TSG1}.
CC -!- SUBUNIT: Interacts with TACC2 and TACC3. Interacts with CCDC52.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250}. Note=Regulates the
CC localization of TACC3 to the centrosome in neural progenitors in
CC vivo. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0JN62-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0JN62-2; Sequence=VSP_035122;
CC -!- SIMILARITY: Belongs to the CEP120 family. {ECO:0000305}.
DR EMBL; AAFC03099167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFC03125893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFC03125142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFC03099169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFC03131164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFC03126660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126531; AAI26532.1; -; mRNA.
DR RefSeq; NP_001071468.1; NM_001078000.2. [A0JN62-2]
DR RefSeq; XP_005209165.1; XM_005209108.3. [A0JN62-1]
DR RefSeq; XP_005209166.1; XM_005209109.3. [A0JN62-1]
DR RefSeq; XP_010805402.1; XM_010807100.2. [A0JN62-1]
DR RefSeq; XP_010805403.1; XM_010807101.2. [A0JN62-1]
DR UniGene; Bt.59429; -.
DR STRING; 9913.ENSBTAP00000041320; -.
DR PaxDb; A0JN62; -.
DR PRIDE; A0JN62; -.
DR Ensembl; ENSBTAT00000017545; ENSBTAP00000017545; ENSBTAG00000013184. [A0JN62-2]
DR Ensembl; ENSBTAT00000043775; ENSBTAP00000041320; ENSBTAG00000013184. [A0JN62-1]
DR GeneID; 534400; -.
DR KEGG; bta:534400; -.
DR CTD; 153241; -.
DR eggNOG; ENOG410IDYJ; Eukaryota.
DR eggNOG; ENOG410XNN2; LUCA.
DR GeneTree; ENSGT00390000009378; -.
DR HOGENOM; HOG000007674; -.
DR HOVERGEN; HBG107643; -.
DR InParanoid; A0JN62; -.
DR KO; K16459; -.
DR OMA; LKTQNEH; -.
DR OrthoDB; EOG091G074C; -.
DR TreeFam; TF329430; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000013184; -.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0030953; P:astral microtubule organization; IEA:Ensembl.
DR GO; GO:0051297; P:centrosome organization; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0022027; P:interkinetic nuclear migration; IEA:Ensembl.
DR GO; GO:0022008; P:neurogenesis; IEA:Ensembl.
DR GO; GO:0010825; P:positive regulation of centrosome duplication; IEA:Ensembl.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR022136; DUF3668.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF12416; DUF3668; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1 987 Centrosomal protein of 120 kDa.
FT /FTId=PRO_0000348261.
FT COILED 670 919 {ECO:0000255}.
FT MOD_RES 936 936 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q7TSG1}.
FT VAR_SEQ 621 671 Missing (in isoform 2).
FT {ECO:0000303|Ref.2}.
FT /FTId=VSP_035122.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 11 114 ipfam:C2 [T]
FT MYHIT 118 340 ipfam:DUF3668 [T]
FT MYHIT 530 562 ipfam:C2 [T]
SQ SEQUENCE 987 AA; 112913 MW; 4723C6D958F13E8B CRC64;
MVSKSDQLLI VVSILEGRHF PKRPKHMLIV EAKFDGEQLA TDPVDHTDQP EFATELAWEI
DRKALHQHRL QRTPIKLQCF ALDPSTSARE TIGYIVLDLR TAQETKQAPK WYQLLSNKYT
KFKSEIQISI ALETDTKAPV DSFKAKGAPP RDGKVPASLS GLDPKDIVAV LNEEGGYHQI
GPAGYCTDFF IMSVTIAFAT QLEQLIPCTM KLPERQPEFF FYYSLLGNDV TNEPFSDLIN
PNFEPERASV RIRSSIEILR VYLTLHSKLQ IHLCCGDQSL GSTEIPLTGL LKKGSTEINH
RPVTVEGAFT LDPPNRAKQK LAPIPVELAP TVGVSVALQR EGMDVQSLIE LKTQNEHEPH
HSKKRVLTPI KENTHTGPQS PSESPVPPHN QSPPTKDDAT ESEVESLLYD KDTKLNPKAI
SSSVPALLAK PVTTSIASEA ASGQKIAVPA TSHHFCFSID LRSIHDLEVG FPINCILRYS
YPFFGSAAPI MTNPPVEVRK NMEVFLPQSY CAFDFATLPH QLQDTFLRIP LLVELWHKDK
MSKDLLLGIA RIQLSNILSS EKTRFLGSNG EQCWRQTFSE SVPIVATQGS NNRIVDLSYT
VTLEDYGLVK MREIFVSDSS QGLSAVQQKP SSVPPAPCPS EIQTEPRETL EYKAALELEM
WKEMQEDIFE NQLKQKELAH MQALAEEWKK RDRERESLVK KKVAEYNILE GKLQKTLIDL
EKREQQLAIA ESELQRERRE LKSERERNLQ ELQDSIRRAK EDCVHQVELE RLKMKQLEED
KHRLQQQLND AENKYKTLEK EFHQFKDQQS SKPEIRLQSE INLLTLEKVE LERKLESATK
SKLHYKQQWG RALKELARLK QREQESQMAR LKKQQEELEQ MRLRYLAAEE KDTVKTERQE
LLDIRNELNR LRQQEQKQYP DSREIASGKM DGPHGSALEE GLDDYLTRLI EERDTLMRTG
VYNHEDRIIS ELDRQIREVL AKNNASN
//
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