ID CCME_YERPS Reviewed; 164 AA.
AC Q668U2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 02-NOV-2016, entry version 66.
DE RecName: Full=Cytochrome c-type biogenesis protein CcmE {ECO:0000255|HAMAP-Rule:MF_01959};
DE AltName: Full=Cytochrome c maturation protein E {ECO:0000255|HAMAP-Rule:MF_01959};
DE AltName: Full=Heme chaperone CcmE {ECO:0000255|HAMAP-Rule:MF_01959};
GN Name=ccmE {ECO:0000255|HAMAP-Rule:MF_01959};
GN Synonyms=cycJ {ECO:0000255|HAMAP-Rule:MF_01959};
GN OrderedLocusNames=YPTB2645;
OS Yersinia pseudotuberculosis serotype I (strain IP32953).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=273123;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP32953;
RX PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA Derbise A., Hauser L.J., Garcia E.;
RT "Insights into the evolution of Yersinia pestis through whole-genome
RT comparison with Yersinia pseudotuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC -!- FUNCTION: Heme chaperone required for the biogenesis of c-type
CC cytochromes. Transiently binds heme delivered by CcmC and
CC transfers the heme to apo-cytochromes in a process facilitated by
CC CcmF and CcmH. {ECO:0000255|HAMAP-Rule:MF_01959}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01959}; Single-pass type II membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01959}; Periplasmic side
CC {ECO:0000255|HAMAP-Rule:MF_01959}.
CC -!- SIMILARITY: Belongs to the CcmE/CycJ family. {ECO:0000255|HAMAP-
CC Rule:MF_01959}.
DR EMBL; BX936398; CAH21883.1; -; Genomic_DNA.
DR RefSeq; WP_002209697.1; NZ_CP009712.1.
DR ProteinModelPortal; Q668U2; -.
DR EnsemblBacteria; CAH21883; CAH21883; YPTB2645.
DR KEGG; ypo:BZ17_3994; -.
DR KEGG; yps:YPTB2645; -.
DR PATRIC; 18644339; VBIYerPse22266_3227.
DR HOGENOM; HOG000009661; -.
DR KO; K02197; -.
DR OMA; HVEFAVH; -.
DR Proteomes; UP000001011; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR GO; GO:0017003; P:protein-heme linkage; IEA:UniProtKB-HAMAP.
DR HAMAP; MF_01959; CcmE; 1.
DR InterPro; IPR004329; CcmE.
DR Pfam; PF03100; CcmE; 1.
DR SUPFAM; SSF82093; SSF82093; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome;
KW Cytochrome c-type biogenesis; Heme; Iron; Membrane; Metal-binding;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 164 Cytochrome c-type biogenesis protein
FT CcmE.
FT /FTId=PRO_0000238894.
FT TOPO_DOM 1 8 Cytoplasmic. {ECO:0000255|HAMAP-
FT Rule:MF_01959}.
FT TRANSMEM 9 29 Helical; Signal-anchor for type II
FT membrane protein. {ECO:0000255|HAMAP-
FT Rule:MF_01959}.
FT TOPO_DOM 30 164 Periplasmic. {ECO:0000255|HAMAP-
FT Rule:MF_01959}.
FT METAL 134 134 Iron (heme axial ligand).
FT {ECO:0000255|HAMAP-Rule:MF_01959}.
FT BINDING 130 130 Heme (covalent; via pros nitrogen).
FT {ECO:0000255|HAMAP-Rule:MF_01959}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 4 137 ipfam:CcmE [T]
FT MYHIT 2 147 ihamap:CcmE [T]
SQ SEQUENCE 164 AA; 18033 MW; 5EF4E74F50596559 CRC64;
MNPRRKSRLY LAMVVLIGIS LTTTLVLYAL RSNIDLFYTP GEILQGKGER HEKPAIGQRL
RIGGMVMPGS VQRDAKTLEM SFQVYDARGA VTVTYTGILP DLFREGQGVV AQGVFAEGNT
VHAKEVLAKH DEKYTPPEVE EAMKENHSRP AAAYRGTNTT GNAL
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