ID CCME_YERPN Reviewed; 164 AA.
AC Q1CHJ3; C4GU90;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 02-NOV-2016, entry version 69.
DE RecName: Full=Cytochrome c-type biogenesis protein CcmE {ECO:0000255|HAMAP-Rule:MF_01959};
DE AltName: Full=Cytochrome c maturation protein E {ECO:0000255|HAMAP-Rule:MF_01959};
DE AltName: Full=Heme chaperone CcmE {ECO:0000255|HAMAP-Rule:MF_01959};
GN Name=ccmE {ECO:0000255|HAMAP-Rule:MF_01959};
GN Synonyms=cycJ {ECO:0000255|HAMAP-Rule:MF_01959};
GN OrderedLocusNames=YPN_2209; ORFNames=YP516_2474;
OS Yersinia pestis bv. Antiqua (strain Nepal516).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=377628;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nepal516;
RX PubMed=16740952; DOI=10.1128/JB.00124-06;
RA Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT "Complete genome sequence of Yersinia pestis strains Antiqua and
RT Nepal516: evidence of gene reduction in an emerging pathogen.";
RL J. Bacteriol. 188:4453-4463(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nepal516;
RA Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C.,
RA Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C.,
RA Brettin T.S.;
RT "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Heme chaperone required for the biogenesis of c-type
CC cytochromes. Transiently binds heme delivered by CcmC and
CC transfers the heme to apo-cytochromes in a process facilitated by
CC CcmF and CcmH. {ECO:0000255|HAMAP-Rule:MF_01959}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01959}; Single-pass type II membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01959}; Periplasmic side
CC {ECO:0000255|HAMAP-Rule:MF_01959}.
CC -!- SIMILARITY: Belongs to the CcmE/CycJ family. {ECO:0000255|HAMAP-
CC Rule:MF_01959}.
DR EMBL; CP000305; ABG18537.1; -; Genomic_DNA.
DR EMBL; ACNQ01000013; EEO76277.1; -; Genomic_DNA.
DR RefSeq; WP_002209697.1; NZ_ACNQ01000013.1.
DR ProteinModelPortal; Q1CHJ3; -.
DR EnsemblBacteria; ABG18537; ABG18537; YPN_2209.
DR EnsemblBacteria; EEO76277; EEO76277; YP516_2474.
DR KEGG; ypn:YPN_2209; -.
DR PATRIC; 18603982; VBIYerPes46733_2651.
DR HOGENOM; HOG000009661; -.
DR KO; K02197; -.
DR OMA; HVEFAVH; -.
DR Proteomes; UP000008936; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR GO; GO:0017003; P:protein-heme linkage; IEA:UniProtKB-HAMAP.
DR HAMAP; MF_01959; CcmE; 1.
DR InterPro; IPR004329; CcmE.
DR Pfam; PF03100; CcmE; 1.
DR SUPFAM; SSF82093; SSF82093; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome;
KW Cytochrome c-type biogenesis; Heme; Iron; Membrane; Metal-binding;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 164 Cytochrome c-type biogenesis protein
FT CcmE.
FT /FTId=PRO_1000070871.
FT TOPO_DOM 1 8 Cytoplasmic. {ECO:0000255|HAMAP-
FT Rule:MF_01959}.
FT TRANSMEM 9 29 Helical; Signal-anchor for type II
FT membrane protein. {ECO:0000255|HAMAP-
FT Rule:MF_01959}.
FT TOPO_DOM 30 164 Periplasmic. {ECO:0000255|HAMAP-
FT Rule:MF_01959}.
FT METAL 134 134 Iron (heme axial ligand).
FT {ECO:0000255|HAMAP-Rule:MF_01959}.
FT BINDING 130 130 Heme (covalent; via pros nitrogen).
FT {ECO:0000255|HAMAP-Rule:MF_01959}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 2 147 ihamap:CcmE [T]
FT MYHIT 4 137 ipfam:CcmE [T]
SQ SEQUENCE 164 AA; 18033 MW; 5EF4E74F50596559 CRC64;
MNPRRKSRLY LAMVVLIGIS LTTTLVLYAL RSNIDLFYTP GEILQGKGER HEKPAIGQRL
RIGGMVMPGS VQRDAKTLEM SFQVYDARGA VTVTYTGILP DLFREGQGVV AQGVFAEGNT
VHAKEVLAKH DEKYTPPEVE EAMKENHSRP AAAYRGTNTT GNAL
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