ID CC159_HUMAN Reviewed; 412 AA.
AC P0C7I6; B4DEG3; B4DWR8; B4E133; B7ZAM4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 02-NOV-2016, entry version 56.
DE RecName: Full=Coiled-coil domain-containing protein 159;
GN Name=CCDC159;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-345 (ISOFORM 2), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-304 (ISOFORM 4).
RC TISSUE=Cerebellum, Esophagus, Spleen, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-406 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=P0C7I6-1; Sequence=Displayed;
CC Note=No experimental confirmation.;
CC Name=2;
CC IsoId=P0C7I6-2; Sequence=VSP_040536, VSP_040537;
CC Name=3;
CC IsoId=P0C7I6-3; Sequence=VSP_040535, VSP_040538, VSP_040539,
CC VSP_040540;
CC Name=4;
CC IsoId=P0C7I6-4; Sequence=VSP_040538;
CC Name=5;
CC IsoId=P0C7I6-5; Sequence=VSP_040536, VSP_040537, VSP_040539,
CC VSP_040540;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG63130.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BC038439; Type=Frameshift; Positions=55; Evidence={ECO:0000305};
DR EMBL; AK293611; BAG57074.1; -; mRNA.
DR EMBL; AK301653; BAG63130.1; ALT_SEQ; mRNA.
DR EMBL; AK303641; BAG64645.1; -; mRNA.
DR EMBL; AK316339; BAH14710.1; -; mRNA.
DR EMBL; AC024575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038439; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45976.1; -. [P0C7I6-2]
DR RefSeq; NP_001073972.2; NM_001080503.2. [P0C7I6-2]
DR UniGene; Hs.631636; -.
DR ProteinModelPortal; P0C7I6; -.
DR SMR; P0C7I6; -.
DR BioGrid; 125955; 1.
DR STRING; 9606.ENSP00000402239; -.
DR iPTMnet; P0C7I6; -.
DR PhosphoSitePlus; P0C7I6; -.
DR DMDM; 189041677; -.
DR PaxDb; P0C7I6; -.
DR PRIDE; P0C7I6; -.
DR Ensembl; ENST00000458408; ENSP00000402239; ENSG00000183401. [P0C7I6-2]
DR Ensembl; ENST00000588790; ENSP00000468232; ENSG00000183401. [P0C7I6-2]
DR GeneID; 126075; -.
DR KEGG; hsa:126075; -.
DR UCSC; uc010xlt.3; human. [P0C7I6-1]
DR CTD; 126075; -.
DR GeneCards; CCDC159; -.
DR HGNC; HGNC:26996; CCDC159.
DR HPA; HPA047126; -.
DR HPA; HPA054655; -.
DR neXtProt; NX_P0C7I6; -.
DR OpenTargets; ENSG00000183401; -.
DR eggNOG; ENOG410J016; Eukaryota.
DR eggNOG; ENOG41114KW; LUCA.
DR GeneTree; ENSGT00390000008201; -.
DR HOGENOM; HOG000139146; -.
DR HOVERGEN; HBG106503; -.
DR InParanoid; P0C7I6; -.
DR OMA; WPETEEI; -.
DR OrthoDB; EOG091G0A8B; -.
DR PhylomeDB; P0C7I6; -.
DR BioCyc; ZFISH:G66-33079-MONOMER; -.
DR ChiTaRS; CCDC159; human.
DR GenomeRNAi; 126075; -.
DR PRO; PR:P0C7I6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000183401; -.
DR ExpressionAtlas; P0C7I6; baseline and differential.
DR Genevisible; P0C7I6; HS.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 412 Coiled-coil domain-containing protein
FT 159.
FT /FTId=PRO_0000332996.
FT COILED 262 298 {ECO:0000255}.
FT VAR_SEQ 1 116 Missing (in isoform 3).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_040535.
FT VAR_SEQ 1 115 Missing (in isoform 2 and isoform 5).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_040536.
FT VAR_SEQ 116 122 RHHNVAK -> MGEHEQV (in isoform 2 and
FT isoform 5).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_040537.
FT VAR_SEQ 117 122 HHNVAK -> MNRWYV (in isoform 3 and
FT isoform 4).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_040538.
FT VAR_SEQ 256 292 SKKFLWEELELVREEVTFIYQKLQAQEDEISENLVNI ->
FT RSGMAGGQLGVHRREGRPRTGEWRQDGGNGRCLGEGD (in
FT isoform 3 and isoform 5).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_040539.
FT VAR_SEQ 293 412 Missing (in isoform 3 and isoform 5).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_040540.
FT VARIANT 393 393 C -> S (in dbSNP:rs6887).
FT /FTId=VAR_043032.
FT CONFLICT 121 121 A -> S (in Ref. 2; BC038439).
FT {ECO:0000305}.
SQ SEQUENCE 412 AA; 46012 MW; 9877797635431886 CRC64;
MLLPASDPLL AGLPRDPDYS VSCLYSPPSP SSMCLPANMK CDKYWGSSSD KALERTAHWS
RTPEPETLGC PASGDTVRTA DCRPGWGSGP SPHEAAPSPS PDLQKQCCND QDILKRHHNV
AKKPLETSSS KVKAKTIVMI PDSQKLLRCE LESLKSQLQA QTKAFEFLNH SVTMLEKESC
LQQIKIQQLE EVLSPTGRQG EKEEHKWGME QGRQELYGAL TQGLQGLEKT LRDSEEMQRA
RTTRCLQLLA QEIRDSKKFL WEELELVREE VTFIYQKLQA QEDEISENLV NIQKMQKTQV
KCRKILTKMK QQGHETAACP ETEEIPQGAS GCWKDDLQKE LSDIWSAVHV LQNSIDSLTL
CSGACPKASS LRGHKGHQCL SPPLPSWDSD SDCDQDLSQP PFSKSGRSFP PA
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