ID CC134_MOUSE Reviewed; 229 AA.
AC Q8C7V8; Q3U3V9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 02-NOV-2016, entry version 91.
DE RecName: Full=Coiled-coil domain-containing protein 134;
DE Flags: Precursor;
GN Name=Ccdc134;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Blastocyst, Dendritic cell, and Embryonic stem cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and
RT expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C7V8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C7V8-2; Sequence=VSP_021181;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the UPF0388 family. {ECO:0000305}.
DR EMBL; AK049165; BAC33581.1; -; mRNA.
DR EMBL; AK145747; BAE26624.1; -; mRNA.
DR EMBL; AK154557; BAE32676.1; -; mRNA.
DR EMBL; BC072586; AAH72586.1; -; mRNA.
DR CCDS; CCDS37155.1; -. [Q8C7V8-1]
DR RefSeq; NP_001313517.1; NM_001326588.1. [Q8C7V8-2]
DR RefSeq; NP_766016.2; NM_172428.2. [Q8C7V8-1]
DR UniGene; Mm.440373; -.
DR ProteinModelPortal; Q8C7V8; -.
DR IntAct; Q8C7V8; 1.
DR STRING; 10090.ENSMUSP00000086578; -.
DR PhosphoSitePlus; Q8C7V8; -.
DR EPD; Q8C7V8; -.
DR PaxDb; Q8C7V8; -.
DR PeptideAtlas; Q8C7V8; -.
DR PRIDE; Q8C7V8; -.
DR Ensembl; ENSMUST00000089174; ENSMUSP00000086578; ENSMUSG00000068114. [Q8C7V8-1]
DR GeneID; 76457; -.
DR KEGG; mmu:76457; -.
DR UCSC; uc007wye.1; mouse. [Q8C7V8-1]
DR CTD; 79879; -.
DR MGI; MGI:1923707; Ccdc134.
DR eggNOG; ENOG410IEFZ; Eukaryota.
DR eggNOG; ENOG4111VZ0; LUCA.
DR GeneTree; ENSGT00390000020164; -.
DR HOGENOM; HOG000111386; -.
DR HOVERGEN; HBG081032; -.
DR InParanoid; Q8C7V8; -.
DR OMA; DAYSHVV; -.
DR OrthoDB; EOG091G0Q5S; -.
DR PhylomeDB; Q8C7V8; -.
DR TreeFam; TF323839; -.
DR ChiTaRS; Ccdc134; mouse.
DR PRO; PR:Q8C7V8; -.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000068114; -.
DR CleanEx; MM_CCDC134; -.
DR Genevisible; Q8C7V8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR InterPro; IPR026321; Coiled-coil_dom_con_pro_134.
DR PANTHER; PTHR14735; PTHR14735; 1.
DR Pfam; PF15002; ERK-JNK_inhib; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 22 {ECO:0000255}.
FT CHAIN 23 229 Coiled-coil domain-containing protein
FT 134.
FT /FTId=PRO_0000254110.
FT COILED 196 218 {ECO:0000255}.
FT COMPBIAS 201 218 Arg/Glu/Lys-rich (mixed charge).
FT VAR_SEQ 1 37 Missing (in isoform 2).
FT {ECO:0000303|PubMed:16141072}.
FT /FTId=VSP_021181.
FT CONFLICT 75 75 K -> R (in Ref. 1; BAE32676).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 29 223 ipfam:ERK-JNK_inhib [T]
SQ SEQUENCE 229 AA; 26495 MW; A67A9628EECE1766 CRC64;
MDLLQFLAAF SVLLWPGTEV TGALKSTLDP SLKIYKKMFE VKRREQLLAL KNLAQLNDIH
QQYKILDVML KGLFKVLEDS RTVLIAADVL PDGPVPQDEK LKDAFSHVVE NTAFFGDVVL
RFPKIVHHYF DHNSNWNLLI RWGISFCNQT GVFDQGPHSP ILSLMAQELG ITEKDSDFRN
PFKTDQTEFI PSTDPFQKAL REEEKRRKKE ERRKEIRKGP RISRSQSEL
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