MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Pesticidal crystal protein Cry12Aa; AltName: Full=142 kDa crystal protein; AltName: Full=Crystaline entomocidal protoxin; AltName: Full=Insecticidal delta-endotoxin CryXIIA(a); |
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| MyHits synonyms | C12AA_BACTU , Q45754 , 3D988FFC6C0E3981 |
 Legends: 1, ipfam:Endotoxin_C [T]; 2, ipfam:Endotoxin_N [T].
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ID C12AA_BACTU Reviewed; 1257 AA.
AC Q45754;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 24-JUN-2015, entry version 61.
DE RecName: Full=Pesticidal crystal protein Cry12Aa;
DE AltName: Full=142 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryXIIA(a);
GN Name=cry12Aa; Synonyms=cryVB, cryXIIA(a);
OS Bacillus thuringiensis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1428;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-11.
RC STRAIN=NRRL B-18244 / PS33F2;
RA Narva K.E., Payne J.M., Schwab G.E., Hickle L.A., Galasan T.,
RA Sick A.J.;
RT "Novel Bacillus thuringiensis microbes active against nematodes, and
RT genes encoding novel nematode-active toxins cloned from Bacillus
RT thuringi.";
RL Patent number EP0462721, 27-DEC-1991.
CC -!- FUNCTION: Endotoxin with nematicidal activity.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during
CC sporulation and is accumulated both as an inclusion and as part of
CC the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
DR EMBL; L07027; AAA22355.1; -; Genomic_DNA.
DR ProteinModelPortal; Q45754; -.
DR GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.60.120.260; -; 1.
DR InterPro; IPR005638; Endotoxin_C.
DR InterPro; IPR005639; Endotoxin_N.
DR InterPro; IPR008979; Galactose-bd-like.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 2.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Sporulation; Toxin.
FT CHAIN 1 1257 Pesticidal crystal protein Cry12Aa.
FT /FTId=PRO_0000174085.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 485 618 ipfam:Endotoxin_C [T]
FT MYHIT 76 283 ipfam:Endotoxin_N [T]
SQ SEQUENCE 1257 AA; 142266 MW; 3D988FFC6C0E3981 CRC64;
MATLNEVYPV NYNVLSSDAF QQLDTTGFKS KYDEMIKAFE KKWKKGAKGK DLLDVAWTYI
TTGEIDPLNV IKGVLSVLTL IPEVGTVASA ASTIVSFIWP KIFGDKPNAK NIFEELKPQI
EALIQQDITN YQDAINQKKF DSLQKTINLY TVAIDNNDYV TAKTQLENLN SILTSDISIF
IPEGYETGGL PYYAMVANAH ILLLRDAIVN AEKLGFSDKE VDTHKKYIKM TIHNHTEAVI
KAFLNGLDKF KSLDVNSYNK KANYIKGMTE MVLDLVALWP TFDPDHYQKE VEIEFTRTIS
SPIYQPVPKN MQNTSSSIVP SDLFHYQGDL VKLEFSTRTD NDGLAKIFTG IRNTFYKSPN
THETYHVDFS YNTQSSGNIS RGSSNPIPID LNNPIISTCI RNSFYKAIAG SSVLVNFKDG
TQGYAFAQAP TGGAWDHSFI ESDGAPEGHK LNYIYTSPGD TLRDFINVYT LISTPTINEL
STEKIKGFPA EKGYIKNQGI MKYYGKPEYI NGAQPVNLEN QQTLIFEFHA SKTAQYTIRI
RYASTQGTKG YFRLDNQELQ TLNIPTSHNG YVTGNIGENY DLYTIGSYTI TEGNHTLQIQ
HNDKNGMVLD RIEFVPKDSL QDSPQDSPPE VHESTIIFDK SSPTIWSSNK HSYSHIHLEG
SYTSQGSYPH NLLINLFHPT DPNRNHTIHV NNGDMNVDYG KDSVADGLNF NKITATIPSD
AWYSGTITSM HLFNDNNFKT ITPKFELSNE LENITTQVNA LFASSAQDTL ASNVSDYWIE
QVVMKVDALS DEVFGKEKKA LRKLVNQAKR LSKIRNLLIG GNFDNLVAWY MGKDVVKESD
HELFKSDHVL LPPPTFHPSY IFQKVEESKL KPNTRYTISG FIAHGEDVEL VVSRYGQEIQ
KVMQVPYEEA LPLTSESNSS CCVPNLNINE TLADPHFFSY SIDVGSLEME ANPGIEFGLR
IVKPTGMARV SNLEIREDRP LTAKEIRQVQ RAARDWKQNY EQERTEITAI IQPVLNQINA
LYENEDWNGS IRSNVSYHDL EQIMLPTLLK TEEINCNYDH PAFLLKVYHW FMTDRIGEHG
TILARFQEAL DRAYTQLESR NLLHNGHFTT DTANWTIEGD AHHTILEDGR RVLRLPDWSS
NATQTIEIED FDLDQEYQLL IHAKGKGSIT LQHGEENEYV ETHTHHTNDF ITSQNIPFTF
KGNQIEVHIT SEDGEFLIDH ITVIEVSKTD TNTNIIENSP INTSMNSNVR VDIPRSL
//
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