ID BIOC_PROA2 Reviewed; 268 AA.
AC B4S687;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 02-NOV-2016, entry version 44.
DE RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00835};
DE Short=Malonyl-ACP O-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00835};
DE EC=2.1.1.197 {ECO:0000255|HAMAP-Rule:MF_00835};
DE AltName: Full=Biotin synthesis protein BioC {ECO:0000255|HAMAP-Rule:MF_00835};
GN Name=bioC {ECO:0000255|HAMAP-Rule:MF_00835};
GN OrderedLocusNames=Paes_2187;
OS Prosthecochloris aestuarii (strain DSM 271 / SK 413).
OC Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC Prosthecochloris.
OX NCBI_TaxID=290512;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 271 / SK 413;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F.,
RA Overmann J., Bryant D.A., Richardson P.;
RT "Complete sequence of chromosome of Prosthecochloris aestuarii DSM
RT 271.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts the free carboxyl group of a malonyl-thioester
CC to its methyl ester by transfer of a methyl group from S-adenosyl-
CC L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the
CC fatty acid synthetic pathway. {ECO:0000255|HAMAP-Rule:MF_00835}.
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + malonyl-[acyl-
CC carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-
CC carrier protein] methyl ester. {ECO:0000255|HAMAP-Rule:MF_00835}.
CC -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00835}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00835}.
DR EMBL; CP001108; ACF47189.1; -; Genomic_DNA.
DR RefSeq; WP_012506720.1; NC_011059.1.
DR ProteinModelPortal; B4S687; -.
DR STRING; 290512.Paes_2187; -.
DR EnsemblBacteria; ACF47189; ACF47189; Paes_2187.
DR KEGG; paa:Paes_2187; -.
DR PATRIC; 23044316; VBIProAes37017_2322.
DR eggNOG; ENOG41090JN; Bacteria.
DR eggNOG; ENOG4111P8N; LUCA.
DR HOGENOM; HOG000003262; -.
DR KO; K02169; -.
DR OMA; SCSALQW; -.
DR OrthoDB; POG091H05JY; -.
DR UniPathway; UPA00078; -.
DR Proteomes; UP000002725; Chromosome.
DR GO; GO:0010340; F:carboxyl-O-methyltransferase activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-HAMAP.
DR Gene3D; 3.40.50.150; -; 1.
DR HAMAP; MF_00835; BioC; 1.
DR InterPro; IPR011814; BioC.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR TIGRFAMs; TIGR02072; BioC; 1.
PE 3: Inferred from homology;
KW Biotin biosynthesis; Complete proteome; Methyltransferase;
KW Reference proteome; S-adenosyl-L-methionine; Transferase.
FT CHAIN 1 268 Malonyl-[acyl-carrier protein] O-
FT methyltransferase.
FT /FTId=PRO_0000412518.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 4 256 ihamap:BioC [T]
FT MYHIT 52 149 ipfam:Methyltransf_11 [T]
SQ SEQUENCE 268 AA; 29873 MW; 56B318D3F7A87832 CRC64;
MQQLNKTLIR QRFGRQLHGY NRHAFIQKKM AGHLADMVSA SLASSEVGRL FEIGVGSAAL
TDALLHRLRI DRYYANDLVP QCRQMVETVT ALHGVDSAEF LDGDIEALRE IPGDLDVIVS
GATVQWLEDL PGFFHRMAGA LKPGGVLAFS TFGHDNMQEI RALESVGLHY HTLAEMQAMA
GELYEVTGME EERHQLDFTG PEAVLRHISR TGVNGLDGRA WTKSRHRAFI DRYRRAFSSG
DGVRLTYHTM YCCFRKCPAS AGVEATCC
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