ID AMPE_SHIFL Reviewed; 284 AA.
AC P0AE15; P13017;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 02-NOV-2016, entry version 61.
DE RecName: Full=Protein AmpE;
GN Name=ampE; OrderedLocusNames=SF0108, S0110;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H.,
RA Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J.,
RA Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S.,
RA Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y.,
RA Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/IAI.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W.,
RA Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A.,
RA Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S.,
RA Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella
RT flexneri serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Putative signaling protein in beta-lactamase regulation.
CC AmpE seems not to act as a direct sensor for beta-lactams (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
DR EMBL; AE005674; AAN41772.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP15653.1; -; Genomic_DNA.
DR RefSeq; NP_706065.2; NC_004337.2.
DR RefSeq; WP_000172005.1; NZ_LVJC01000012.1.
DR ProteinModelPortal; P0AE15; -.
DR STRING; 198214.SF0108; -.
DR PaxDb; P0AE15; -.
DR PRIDE; P0AE15; -.
DR EnsemblBacteria; AAN41772; AAN41772; SF0108.
DR EnsemblBacteria; AAP15653; AAP15653; S0110.
DR GeneID; 1027516; -.
DR KEGG; sfl:SF0108; -.
DR KEGG; sft:NCTC1_00108; -.
DR KEGG; sfx:S0110; -.
DR PATRIC; 18701158; VBIShiFle31049_0121.
DR eggNOG; ENOG4106A72; Bacteria.
DR eggNOG; COG3725; LUCA.
DR HOGENOM; HOG000116788; -.
DR KO; K03807; -.
DR OMA; HFSRALP; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR031347; AmpE.
DR Pfam; PF17113; AmpE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 284 Protein AmpE.
FT /FTId=PRO_0000064593.
FT TOPO_DOM 1 43 Periplasmic. {ECO:0000255}.
FT TRANSMEM 44 60 Helical. {ECO:0000255}.
FT TOPO_DOM 61 67 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 68 84 Helical. {ECO:0000255}.
FT TOPO_DOM 85 194 Periplasmic. {ECO:0000255}.
FT TRANSMEM 195 211 Helical. {ECO:0000255}.
FT TOPO_DOM 212 267 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 268 284 Helical. {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 284 ipfam:AmpE [T]
SQ SEQUENCE 284 AA; 32122 MW; C92C05B2DFE0D6AD CRC64;
MTLFTTLLVL IFERLFKLGE HWQLDHRLEA FFRRVKHFSL GRTLGMTIIA MGVTFLLLRA
LQGVLFNVPT LLVWLLIGLL CIGAGKVRLH YHAYLTAASR NDSHARATMA GELTMIHGVP
AGCDEREYLR ELQNALLWIN FRFYLAPLFW LIVGGTWGPV TLMGYAFLRA WQYWLARYQT
PHHRLQSGID AVLHVLDWVP VRLAGVVYAL IGHGEKALPA WFASLGDFHT SQYQVLTRLA
QFSLAREPHV DKVETPKAAV SMAKKTSFVV VVVIALLTIY GALV
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