MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=AFG3-like protein 2; EC=3.4.24.- {ECO:0000250|UniProtKB:Q9Y4W6}; |
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| MyHits synonyms | AFG32_BOVIN , Q2KJI7 , 850FF0D0D111F1BF |
 Legends: 1, ACT_SITE {ECO:0000250|UniProtKB:Q9WZ49}; 2, Zinc; catalytic. {ECO:0000250|UniProtKB:Q9WZ49}; 3, N6-succinyllysine. {ECO:0000250|UniProtKB:Q8JZQ2}; 4, TRANSMEM Helical. {ECO:0000255}; 5, NP_BIND ATP. {ECO:0000255}; 6, ipfam:FtsH_ext [T]; 7, ipat:AAA [T].
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ID AFG32_BOVIN Reviewed; 805 AA.
AC Q2KJI7;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 30-NOV-2016, entry version 83.
DE RecName: Full=AFG3-like protein 2;
DE EC=3.4.24.- {ECO:0000250|UniProtKB:Q9Y4W6};
GN Name=AFG3L2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent protease which is essential for axonal and
CC neuron development. In neurons, mediates degradation of SMDT1/EMRE
CC before its assembly with the uniporter complex, limiting the
CC availability of SMDT1/EMRE for MCU assembly and promoting
CC efficient assembly of gatekeeper subunits with MCU.
CC {ECO:0000250|UniProtKB:Q9Y4W6}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000250|UniProtKB:Q9WZ49};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:Q9WZ49};
CC -!- SUBUNIT: Homooligomer. Interacts with SPG7; the interaction is
CC required for the efficient assembly of mitochondrial complex I.
CC Interacts with MAIP1. {ECO:0000250|UniProtKB:Q9Y4W6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q9Y4W6}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9Y4W6}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase
CC M41 family. {ECO:0000305}.
DR EMBL; BC105322; AAI05323.1; -; mRNA.
DR RefSeq; NP_001039676.1; NM_001046211.1.
DR UniGene; Bt.1657; -.
DR ProteinModelPortal; Q2KJI7; -.
DR STRING; 9913.ENSBTAP00000030993; -.
DR MEROPS; M41.016; -.
DR PaxDb; Q2KJI7; -.
DR PRIDE; Q2KJI7; -.
DR Ensembl; ENSBTAT00000031029; ENSBTAP00000030993; ENSBTAG00000011250.
DR GeneID; 515757; -.
DR KEGG; bta:515757; -.
DR CTD; 10939; -.
DR eggNOG; KOG0731; Eukaryota.
DR eggNOG; COG0465; LUCA.
DR GeneTree; ENSGT00860000133808; -.
DR HOGENOM; HOG000217277; -.
DR HOVERGEN; HBG050184; -.
DR InParanoid; Q2KJI7; -.
DR KO; K08956; -.
DR OMA; CLRLWGR; -.
DR OrthoDB; EOG091G03EQ; -.
DR TreeFam; TF105004; -.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000011250; -.
DR GO; GO:0005745; C:m-AAA complex; IEA:Ensembl.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IBA:GO_Central.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007409; P:axonogenesis; ISS:UniProtKB.
DR GO; GO:0036444; P:calcium ion transmembrane import into mitochondrion; ISS:UniProtKB.
DR GO; GO:0042407; P:cristae formation; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0008053; P:mitochondrial fusion; IBA:GO_Central.
DR GO; GO:0034982; P:mitochondrial protein processing; IBA:GO_Central.
DR GO; GO:0048747; P:muscle fiber development; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0006461; P:protein complex assembly; IBA:GO_Central.
DR GO; GO:0045041; P:protein import into mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; ISS:UniProtKB.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0060013; P:righting reflex; IEA:Ensembl.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01241; FtsH_fam; 1.
DR PROSITE; PS00674; AAA; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Complete proteome; Hydrolase; Membrane; Metal-binding;
KW Metalloprotease; Mitochondrion; Nucleotide-binding; Protease;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc.
FT CHAIN 1 805 AFG3-like protein 2.
FT /FTId=PRO_0000260448.
FT TRANSMEM 144 164 Helical. {ECO:0000255}.
FT TRANSMEM 252 272 Helical. {ECO:0000255}.
FT NP_BIND 349 356 ATP. {ECO:0000255}.
FT ACT_SITE 576 576 {ECO:0000250|UniProtKB:Q9WZ49}.
FT METAL 575 575 Zinc; catalytic.
FT {ECO:0000250|UniProtKB:Q9WZ49}.
FT METAL 579 579 Zinc; catalytic.
FT {ECO:0000250|UniProtKB:Q9WZ49}.
FT METAL 650 650 Zinc; catalytic.
FT {ECO:0000250|UniProtKB:Q9WZ49}.
FT MOD_RES 118 118 N6-succinyllysine.
FT {ECO:0000250|UniProtKB:Q8JZQ2}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 157 241 ipfam:FtsH_ext [T]
FT MYHIT 34 770 ihamap:FtsH [T]
FT MYHIT 341 480 ismart:AAA [T]
FT MYHIT 543 744 ipfam:Peptidase_M41 [T]
FT MYHIT 448 466 ipat:AAA [T]
FT MYHIT 346 477 ipfam:AAA [T]
SQ SEQUENCE 805 AA; 89388 MW; 850FF0D0D111F1BF CRC64;
MAHRCLLLWG RGACRPRGMP PMLLPGGRTG STERLYLRML YRYATTQAKT SRNSLLTDVI
AAYQRLCSRP PKGFEKYFPN GKNGKKTSEP KEVMGEKKEP KPAAAPRPSG GGVGGGGKRG
GKKDDSHWWS RFQKGDIPWD DKEFKMYFLW TALFWGGFLF YFLFKSSGRE ITWKDFANNY
LSKGVVDRLE VVNKRFVRVT FTPGKTPVDG QYVWFNIGSV DTFERNLETL QQELGIEGEN
RVPVVYIAES DGSFLLSMLP TVLIIAFLLY TIRRGPAGIG RTGRGMGGLF SVGETTAKVL
KDEIDVKFKD VAGCEEAKLE IMEFVNFLKN PKQYQDLGAK IPKGAILTGP PGTGKTLLAK
ATAGEANVPF ITVSGSEFLE MFVGVGPARV RDLFALARKN APCILFIDEI DAVGRKRGRG
NFGGQSEQEN TLNQLLVEMD GFNTTTNVVI LAGTNRPDIL DPALMRPGRF DRQIFIGPPD
IKGRASIFKV HLRPLKLDST LEKEKLARKL ASLTPGFSGA DVANVCNEAA LIAARHLSDS
INQKHFEQAI ERVIGGLEKK TQVLQPEEKK TVAYHEAGHA VAGWYLEHAD PLLKVSIIPR
GKGLGYAQYL PREQYLYTRE QLLDRMCMTL GGRVSEEIFF GRITTGAQDD LRKVTQSAYA
QIVQFGMNEK VGQISFDLPR QGDMVLEKPY SEATARLIDD EVRILINDAY KRTVALLTEK
KADVEKVALL LLEKEVLDKN DMVELLGPRP FAEKSTYEEF VEGTGSLDED TSLPEGLKDW
NREREGSEEP SGEKVTSPVQ GAGPA
//
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