ID ADCC_STRPN Reviewed; 234 AA.
AC P0A2U6; O87862;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 02-NOV-2016, entry version 73.
DE RecName: Full=Zinc transport system ATP-binding protein AdcC;
GN Name=adcC; OrderedLocusNames=SP_2171;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T.,
RA Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C.,
RA Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
RN [2]
RP FUNCTION.
RX PubMed=9379902; DOI=10.1046/j.1365-2958.1997.5111879.x;
RA Dintilhac A., Alloing G., Granadel C., Claverys J.-P.;
RT "Competence and virulence of Streptococcus pneumoniae: Adc and PsaA
RT mutants exhibit a requirement for Zn and Mn resulting from
RT inactivation of putative ABC metal permeases.";
RL Mol. Microbiol. 25:727-739(1997).
CC -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC Required for transformability. {ECO:0000269|PubMed:9379902}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC {ECO:0000305}.
CC -!- SIMILARITY: Contains 1 ABC transporter domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00434}.
DR EMBL; AE005672; AAK76225.1; -; Genomic_DNA.
DR PIR; H95253; H95253.
DR RefSeq; WP_001269474.1; NZ_AKVY01000001.1.
DR ProteinModelPortal; P0A2U6; -.
DR STRING; 170187.SpneT_02000552; -.
DR TCDB; 3.A.1.15.3; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAK76225; AAK76225; SP_2171.
DR KEGG; spn:SP_2171; -.
DR PATRIC; 19708949; VBIStrPne105772_2266.
DR eggNOG; ENOG4105FDK; Bacteria.
DR eggNOG; COG1121; LUCA.
DR KO; K09817; -.
DR OMA; EGSPWRC; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0006829; P:zinc II ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like.
DR InterPro; IPR017871; ABC_transporter_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Competence; Complete proteome; Ion transport;
KW Nucleotide-binding; Transport; Zinc; Zinc transport.
FT CHAIN 1 234 Zinc transport system ATP-binding protein
FT AdcC.
FT /FTId=PRO_0000091922.
FT DOMAIN 4 234 ABC transporter. {ECO:0000255|PROSITE-
FT ProRule:PRU00434}.
FT NP_BIND 36 43 ATP. {ECO:0000255|PROSITE-
FT ProRule:PRU00434}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 138 152 ipat:ABC_TRANSPORTER_1 [T]
FT MYHIT 4 234 iprf:ABC_TRANSPORTER_2 [T]
FT MYHIT 28 216 ismart:AAA [T]
FT MYHIT 19 165 ipfam:ABC_tran [T]
SQ SEQUENCE 234 AA; 26542 MW; 2AF782EF93D5C1A0 CRC64;
MRYITVEDLS FYYDKEPVLE HINYCVDSGE FVTLTGENGA AKTTLIKASL GILQPRIGKV
AISKTNTQGK KLRIAYLPQQ IASFNAGFPS TVYEFVKSGR YPRKGWFRRL NAHDEEHIKA
SLDSVGMWEH RDKRLGSLSG GQKQRAVIAR MFASDPDVFI LDEPTTGMDA GSKNEFYELM
HHSAHHHGKA VLMITHDPEE VKDYADRNIH LVRNQDSPWR CFNVHENGQE VGHA
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