ID ZN772_HUMAN Reviewed; 489 AA.
AC Q68DY9; A6NJK9; B4DH56; B4DYS0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 10-MAY-2017, entry version 120.
DE RecName: Full=Zinc finger protein 772;
GN Name=ZNF772;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Brain, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
RP VARIANTS TRP-182 AND LEU-218.
RC TISSUE=Endometrial tumor, and Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC P50542:PEX5; NbExp=3; IntAct=EBI-10249148, EBI-597835;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q68DY9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68DY9-2; Sequence=VSP_021882;
CC Name=3;
CC IsoId=Q68DY9-3; Sequence=VSP_043423;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK294941; BAG58017.1; -; mRNA.
DR EMBL; AK302574; BAG63832.1; -; mRNA.
DR EMBL; BX647068; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CR749225; CAH18081.1; -; mRNA.
DR EMBL; AC003005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33133.1; -. [Q68DY9-1]
DR CCDS; CCDS46210.1; -. [Q68DY9-3]
DR CCDS; CCDS82406.1; -. [Q68DY9-2]
DR RefSeq; NP_001019767.1; NM_001024596.2. [Q68DY9-1]
DR RefSeq; NP_001137540.1; NM_001144068.1. [Q68DY9-3]
DR RefSeq; NP_001317542.1; NM_001330613.1. [Q68DY9-2]
DR RefSeq; XP_005259001.1; XM_005258944.3. [Q68DY9-2]
DR UniGene; Hs.388810; -.
DR ProteinModelPortal; Q68DY9; -.
DR SMR; Q68DY9; -.
DR BioGrid; 134722; 2.
DR IntAct; Q68DY9; 2.
DR STRING; 9606.ENSP00000341165; -.
DR iPTMnet; Q68DY9; -.
DR PhosphoSitePlus; Q68DY9; -.
DR BioMuta; ZNF772; -.
DR DMDM; 119368827; -.
DR PaxDb; Q68DY9; -.
DR PeptideAtlas; Q68DY9; -.
DR PRIDE; Q68DY9; -.
DR DNASU; 400720; -.
DR Ensembl; ENST00000343280; ENSP00000341165; ENSG00000197128. [Q68DY9-1]
DR Ensembl; ENST00000356584; ENSP00000348992; ENSG00000197128. [Q68DY9-3]
DR Ensembl; ENST00000427512; ENSP00000395967; ENSG00000197128. [Q68DY9-2]
DR GeneID; 400720; -.
DR KEGG; hsa:400720; -.
DR UCSC; uc002qot.3; human. [Q68DY9-1]
DR CTD; 400720; -.
DR GeneCards; ZNF772; -.
DR HGNC; HGNC:33106; ZNF772.
DR HPA; HPA031312; -.
DR neXtProt; NX_Q68DY9; -.
DR OpenTargets; ENSG00000197128; -.
DR PharmGKB; PA162410356; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119107; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q68DY9; -.
DR KO; K09228; -.
DR OMA; FHSGQKH; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q68DY9; -.
DR TreeFam; TF342033; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 400720; -.
DR PRO; PR:Q68DY9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000197128; -.
DR CleanEx; HS_ZNF772; -.
DR ExpressionAtlas; Q68DY9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 489 Zinc finger protein 772.
FT /FTId=PRO_0000263689.
FT DOMAIN 27 98 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 144 166 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 172 194 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 266 288 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 294 316 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 322 344 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 350 372 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 378 400 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 406 428 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 434 456 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 462 484 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 1 112 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005}.
FT /FTId=VSP_021882.
FT VAR_SEQ 67 107 Missing (in isoform 3).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_043423.
FT VARIANT 182 182 C -> W (in dbSNP:rs2074060).
FT {ECO:0000269|PubMed:17974005}.
FT /FTId=VAR_029604.
FT VARIANT 218 218 M -> L (in dbSNP:rs2074059).
FT {ECO:0000269|PubMed:17974005}.
FT /FTId=VAR_029605.
FT CONFLICT 369 369 E -> G (in Ref. 2; CAH18081).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 266 293 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 324 344 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 172 199 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 27 67 ipfam:KRAB [T]
FT MYHIT 27 98 iprf:KRAB [T]
FT MYHIT 464 484 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 434 456 ismart:ZnF_C2H2 [T]
FT MYHIT 322 344 ismart:ZnF_C2H2 [T]
FT MYHIT 268 288 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 406 433 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 350 372 ismart:ZnF_C2H2 [T]
FT MYHIT 294 321 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 462 484 ismart:ZnF_C2H2 [T]
FT MYHIT 266 288 ismart:ZnF_C2H2 [T]
FT MYHIT 350 377 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 172 194 ismart:ZnF_C2H2 [T]
FT MYHIT 174 194 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 322 349 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 146 166 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 378 405 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 408 428 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 406 428 ismart:ZnF_C2H2 [T]
FT MYHIT 296 316 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 434 461 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 378 400 ismart:ZnF_C2H2 [T]
FT MYHIT 352 372 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 144 171 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 27 87 ismart:KRAB [T]
FT MYHIT 436 456 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 294 316 ismart:ZnF_C2H2 [T]
FT MYHIT 144 166 ismart:ZnF_C2H2 [T]
FT MYHIT 380 400 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 462 489 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 489 AA; 55367 MW; C5F8E4BA5469C32B CRC64;
MAAAEPMGPA QVPMNSEVIV DPIQGQVNFE DVFVYFSQEE WVLLDEAQRL LYRDVMLENF
ALMASLGHTS FMSHIVASLV MGSEPWVPDW VDMTLAVATE TPGGSDPGCW HGMEDEEIPF
EQSFSIGMSQ IRIPKGGPST QKAYPCGTCG LVLKDILHLA EHQETHPGQK PYMCVLCGKQ
FCFSANLHQH QKQHSGEKPF RSDKSRPFLL NNCAVQSMEM SFVTGEACKD FLASSSIFEH
HAPHNEWKPH SNTKCEEASH CGKRHYKCSE CGKTFSRKDS LVQHQRVHTG ERPYECGECG
KTFSRKPILA QHQRIHTGEM PYECGICGKV FNHSSNLIVH QRVHTGARPY KCSECGKAYS
HKSTLVQHES IHTGERPYEC SECGKYFGHK YRLIKHWSVH TGARPYECIA CGKFFSQSSD
LIAHQRVHNG EKPYVCSECG KAFSHKHVLV QHHRIHTGER PYKCSECGKA FRQRASLIRH
WKIHTGERP
//
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