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DescriptionRecName: Full=Zinc finger protein 750;
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MyHits synonymsZN750_MOUSE , Q8BH05 , B1ATU1 , B9EKG8 , Q66JP3 , Q8C0L1 , 5C93367C6595BD8A
match map segment
 
Legends: 1, CONFLICT L -> Q (in Ref. 1; BAC27080). {ECO:0000305}; 2, CONFLICT F -> L (in Ref. 1; BAC27080). {ECO:0000305}; 3, CONFLICT V -> A (in Ref. 3; AAI50906). {ECO:0000305}; 4, ZN_FING C2H2-type; degenerate.
ID   ZN750_MOUSE             Reviewed;         703 AA.
AC   Q8BH05; B1ATU1; B9EKG8; Q66JP3; Q8C0L1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   10-MAY-2017, entry version 98.
DE   RecName: Full=Zinc finger protein 750;
GN   Name=Znf750; Synonyms=Zfp750;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, and Skin;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcription factor involved in epidermis
CC       differentiation. Required for terminal epidermal differentiation:
CC       acts downstream of p63/TP63 and activates expression of late
CC       epidermal differentiation genes. Specifically binds to the
CC       promoter of KLF4 and promotes its expression (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AK030690; BAC27080.1; -; mRNA.
DR   EMBL; AK037185; BAC29743.1; -; mRNA.
DR   EMBL; AK037240; BAC29771.1; -; mRNA.
DR   EMBL; AL663088; CAM19958.1; -; Genomic_DNA.
DR   EMBL; BC150905; AAI50906.1; -; mRNA.
DR   CCDS; CCDS25779.1; -.
DR   RefSeq; NP_848878.1; NM_178763.4.
DR   UniGene; Mm.11395; -.
DR   ProteinModelPortal; Q8BH05; -.
DR   STRING; 10090.ENSMUSP00000089951; -.
DR   PhosphoSitePlus; Q8BH05; -.
DR   PaxDb; Q8BH05; -.
DR   PRIDE; Q8BH05; -.
DR   Ensembl; ENSMUST00000092298; ENSMUSP00000089951; ENSMUSG00000039238.
DR   GeneID; 319530; -.
DR   KEGG; mmu:319530; -.
DR   UCSC; uc007mvz.2; mouse.
DR   CTD; 319530; -.
DR   MGI; MGI:2442210; Zfp750.
DR   eggNOG; ENOG410IF50; Eukaryota.
DR   eggNOG; ENOG410ZK89; LUCA.
DR   GeneTree; ENSGT00530000063870; -.
DR   HOGENOM; HOG000049178; -.
DR   HOVERGEN; HBG080198; -.
DR   InParanoid; Q8BH05; -.
DR   OMA; HYRFFQQ; -.
DR   OrthoDB; EOG091G036R; -.
DR   PhylomeDB; Q8BH05; -.
DR   TreeFam; TF331381; -.
DR   PRO; PR:Q8BH05; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000039238; -.
DR   CleanEx; MM_ZFP750; -.
DR   Genevisible; Q8BH05; MM.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Activator; Complete proteome; Differentiation; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    703       Zinc finger protein 750.
FT                                /FTId=PRO_0000247071.
FT   ZN_FING      25     46       C2H2-type; degenerate.
FT   CONFLICT    131    131       L -> Q (in Ref. 1; BAC27080).
FT                                {ECO:0000305}.
FT   CONFLICT    421    421       F -> L (in Ref. 1; BAC27080).
FT                                {ECO:0000305}.
FT   CONFLICT    638    638       V -> A (in Ref. 3; AAI50906).
FT                                {ECO:0000305}.
SQ   SEQUENCE   703 AA;  76645 MW;  5C93367C6595BD8A CRC64;
     MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
     RIPKCPKSSS LDPKQTHQPE PTSKPATSKS LLNGLSSFDP KSQQGSAKED AKENLEMQAR
     GAHKGPQKPA LQKEMAPEAI LSTQPCLDSG VRHSAFVPVG EHRLRGPEDT EATEVLANST
     TKASSFHAKS AFHTPGYPWK AGSPFLPPDF PHKISSTKGF GAISPYMHPA IPEYPHPFYA
     EHGLAAIYSP YLLTGNTPEC ETTLLSVYGT QDQRHFLSPA GPIPKHLNTS PSTYDHYRFF
     QQYHSNLPIP YGFYRPESAF PSYSLRLPSV TGITRDQSSR LLEDATLAYP ASSPSELNLS
     SSHRKHTECE KGSPVPEAKD PSKDGQRDAE EAKMSPRAGS AATGSPGRPS PTNFTQTSQT
     FEGLCDLSNK AASSGTLERL QQAEQSPTAF KPVQRGSESP HSQPPANRTE SPKSLQAMNG
     DPPAQTGSSN SFITEAPPSS PEDHSRIGPL NLSKKLETNP AATYGPMYAS NAQADTLQDL
     PLNLSVKDLC NAWAPRPALP GPPQGAEPAA TPKTETKGSE DRTSRVETPQ DKAHSRTTPD
     VHTEDSSDEQ KQTAAVALCQ LAAYSPGNVR VADEEGTVQE PTRQDVPTLS ATENLEAQCD
     LRPKGQKRTS QRDTGKSQQG TKKPKLNDPV PRVLTLRRRT RVS
//