ID ZN750_MOUSE Reviewed; 703 AA.
AC Q8BH05; B1ATU1; B9EKG8; Q66JP3; Q8C0L1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 10-MAY-2017, entry version 98.
DE RecName: Full=Zinc finger protein 750;
GN Name=Znf750; Synonyms=Zfp750;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription factor involved in epidermis
CC differentiation. Required for terminal epidermal differentiation:
CC acts downstream of p63/TP63 and activates expression of late
CC epidermal differentiation genes. Specifically binds to the
CC promoter of KLF4 and promotes its expression (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK030690; BAC27080.1; -; mRNA.
DR EMBL; AK037185; BAC29743.1; -; mRNA.
DR EMBL; AK037240; BAC29771.1; -; mRNA.
DR EMBL; AL663088; CAM19958.1; -; Genomic_DNA.
DR EMBL; BC150905; AAI50906.1; -; mRNA.
DR CCDS; CCDS25779.1; -.
DR RefSeq; NP_848878.1; NM_178763.4.
DR UniGene; Mm.11395; -.
DR ProteinModelPortal; Q8BH05; -.
DR STRING; 10090.ENSMUSP00000089951; -.
DR PhosphoSitePlus; Q8BH05; -.
DR PaxDb; Q8BH05; -.
DR PRIDE; Q8BH05; -.
DR Ensembl; ENSMUST00000092298; ENSMUSP00000089951; ENSMUSG00000039238.
DR GeneID; 319530; -.
DR KEGG; mmu:319530; -.
DR UCSC; uc007mvz.2; mouse.
DR CTD; 319530; -.
DR MGI; MGI:2442210; Zfp750.
DR eggNOG; ENOG410IF50; Eukaryota.
DR eggNOG; ENOG410ZK89; LUCA.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; HOG000049178; -.
DR HOVERGEN; HBG080198; -.
DR InParanoid; Q8BH05; -.
DR OMA; HYRFFQQ; -.
DR OrthoDB; EOG091G036R; -.
DR PhylomeDB; Q8BH05; -.
DR TreeFam; TF331381; -.
DR PRO; PR:Q8BH05; -.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000039238; -.
DR CleanEx; MM_ZFP750; -.
DR Genevisible; Q8BH05; MM.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Activator; Complete proteome; Differentiation; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1 703 Zinc finger protein 750.
FT /FTId=PRO_0000247071.
FT ZN_FING 25 46 C2H2-type; degenerate.
FT CONFLICT 131 131 L -> Q (in Ref. 1; BAC27080).
FT {ECO:0000305}.
FT CONFLICT 421 421 F -> L (in Ref. 1; BAC27080).
FT {ECO:0000305}.
FT CONFLICT 638 638 V -> A (in Ref. 3; AAI50906).
FT {ECO:0000305}.
SQ SEQUENCE 703 AA; 76645 MW; 5C93367C6595BD8A CRC64;
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
RIPKCPKSSS LDPKQTHQPE PTSKPATSKS LLNGLSSFDP KSQQGSAKED AKENLEMQAR
GAHKGPQKPA LQKEMAPEAI LSTQPCLDSG VRHSAFVPVG EHRLRGPEDT EATEVLANST
TKASSFHAKS AFHTPGYPWK AGSPFLPPDF PHKISSTKGF GAISPYMHPA IPEYPHPFYA
EHGLAAIYSP YLLTGNTPEC ETTLLSVYGT QDQRHFLSPA GPIPKHLNTS PSTYDHYRFF
QQYHSNLPIP YGFYRPESAF PSYSLRLPSV TGITRDQSSR LLEDATLAYP ASSPSELNLS
SSHRKHTECE KGSPVPEAKD PSKDGQRDAE EAKMSPRAGS AATGSPGRPS PTNFTQTSQT
FEGLCDLSNK AASSGTLERL QQAEQSPTAF KPVQRGSESP HSQPPANRTE SPKSLQAMNG
DPPAQTGSSN SFITEAPPSS PEDHSRIGPL NLSKKLETNP AATYGPMYAS NAQADTLQDL
PLNLSVKDLC NAWAPRPALP GPPQGAEPAA TPKTETKGSE DRTSRVETPQ DKAHSRTTPD
VHTEDSSDEQ KQTAAVALCQ LAAYSPGNVR VADEEGTVQE PTRQDVPTLS ATENLEAQCD
LRPKGQKRTS QRDTGKSQQG TKKPKLNDPV PRVLTLRRRT RVS
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