ID ZN750_DANRE Reviewed; 607 AA.
AC Q568E2; F1R5I0;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 10-MAY-2017, entry version 54.
DE RecName: Full=Zinc finger protein 750;
GN Name=znf750; ORFNames=zgc:110351;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor involved in epidermis
CC differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BX248236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC092893; AAH92893.1; -; mRNA.
DR RefSeq; NP_001017786.1; NM_001017786.1.
DR RefSeq; XP_017209672.1; XM_017354183.1.
DR UniGene; Dr.43003; -.
DR STRING; 7955.ENSDARP00000058642; -.
DR PaxDb; Q568E2; -.
DR Ensembl; ENSDART00000160717; ENSDARP00000131237; ENSDARG00000102267.
DR GeneID; 550483; -.
DR KEGG; dre:550483; -.
DR CTD; 79755; -.
DR ZFIN; ZDB-GENE-050417-313; znf750.
DR eggNOG; ENOG410IF50; Eukaryota.
DR eggNOG; ENOG410ZK89; LUCA.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; HOG000170234; -.
DR InParanoid; Q568E2; -.
DR OMA; FKYQCFQ; -.
DR OrthoDB; EOG091G036R; -.
DR TreeFam; TF331381; -.
DR PRO; PR:Q568E2; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000040098; -.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Activator; Complete proteome; Differentiation; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1 607 Zinc finger protein 750.
FT /FTId=PRO_0000247072.
FT ZN_FING 25 46 C2H2-type; degenerate.
FT CONFLICT 452 452 H -> L (in Ref. 2; AAH92893).
FT {ECO:0000305}.
FT CONFLICT 517 517 Q -> R (in Ref. 2; AAH92893).
FT {ECO:0000305}.
SQ SEQUENCE 607 AA; 68135 MW; AE8293A0C153AA43 CRC64;
METLQGRKPK KPHYIPRPPG KPFKYQCFQC PFTCNIKSHL FNHMKYNLCK NSISLVSQRM
EQTGKASRAS QHSPAFSHNS KELPLDAEST KPIENVKIEK AVTKEAREKP QSPIKEVSKD
DTEPALEAKD KSEDMDIAQN KISSAFSPVA RTCESEALSL SPHKDDQSTI PHFYQQIAPW
VTSASSAHLL PPIPEYPPYM VPERSLPPLY APYPHNQAST PAYQVTPRET QRPLVPSPLI
PPNSSLLHPY HYRYGHSIFP SPPLPYSFYQ HPELSIPLQR SRYLPLDVYS SRFYPREYGG
HLVPLTHPES YSRLAEDRAV QEHNTGDKGI RESPLEGCDA SGSPDRPSTA DVTQRIPVGL
RLASHGESHS GSQSHIISGS TKANDNLPKM PCGQNQEKML QKTERYDSQT TISSRSSDIS
DKEEDEETEE EIGPLNLSKR DQATSNNMTH HHYPDRELHY DSESSQEEAP LNLCLRVQSS
NQALPNTSET PEKETISNAE VSTTESPQDL EPCDQRQTAA FALCQLASSR DIINDTSVKQ
QDVTESQNTK CLPSPDNCSV KDSPNILNAS MVALGQKRAN NRPLRHTNKR AKVKEPSRPR
RKRSQNC
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