ID ZN740_MOUSE Reviewed; 180 AA.
AC Q6NZQ6; Q3UMS3; Q8JZR3;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 10-MAY-2017, entry version 116.
DE RecName: Full=Zinc finger protein 740;
GN Name=Znf740; Synonyms=Zfp740;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6NZQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NZQ6-2; Sequence=VSP_020757;
CC Note=No experimental confirmation available.;
CC Name=3;
CC IsoId=Q6NZQ6-3; Sequence=VSP_020756, VSP_020758;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK144707; BAE26025.1; -; mRNA.
DR EMBL; BC030410; AAH30410.1; -; mRNA.
DR EMBL; BC066011; AAH66011.1; -; mRNA.
DR CCDS; CCDS70672.1; -. [Q6NZQ6-1]
DR CCDS; CCDS79416.1; -. [Q6NZQ6-2]
DR RefSeq; NP_001276620.1; NM_001289691.1. [Q6NZQ6-2]
DR RefSeq; NP_001276624.1; NM_001289695.1. [Q6NZQ6-1]
DR RefSeq; XP_006521399.1; XM_006521336.2. [Q6NZQ6-2]
DR RefSeq; XP_011244021.1; XM_011245719.1. [Q6NZQ6-1]
DR RefSeq; XP_017172230.1; XM_017316741.1. [Q6NZQ6-1]
DR UniGene; Mm.352945; -.
DR ProteinModelPortal; Q6NZQ6; -.
DR SMR; Q6NZQ6; -.
DR IntAct; Q6NZQ6; 1.
DR MINT; MINT-4116638; -.
DR STRING; 10090.ENSMUSP00000113281; -.
DR iPTMnet; Q6NZQ6; -.
DR PhosphoSitePlus; Q6NZQ6; -.
DR PaxDb; Q6NZQ6; -.
DR PeptideAtlas; Q6NZQ6; -.
DR PRIDE; Q6NZQ6; -.
DR Ensembl; ENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897. [Q6NZQ6-2]
DR Ensembl; ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897. [Q6NZQ6-1]
DR GeneID; 68744; -.
DR KEGG; mmu:68744; -.
DR UCSC; uc007xuw.2; mouse. [Q6NZQ6-2]
DR UCSC; uc007xuz.2; mouse. [Q6NZQ6-1]
DR UCSC; uc007xva.2; mouse. [Q6NZQ6-3]
DR CTD; 68744; -.
DR MGI; MGI:1915994; Zfp740.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000063238; -.
DR HOGENOM; HOG000013198; -.
DR HOVERGEN; HBG061583; -.
DR InParanoid; Q6NZQ6; -.
DR OMA; HRKESDK; -.
DR OrthoDB; EOG091G0L6G; -.
DR PhylomeDB; Q6NZQ6; -.
DR PRO; PR:Q6NZQ6; -.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000046897; -.
DR CleanEx; MM_ZFP740; -.
DR ExpressionAtlas; Q6NZQ6; baseline and differential.
DR Genevisible; Q6NZQ6; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 180 Zinc finger protein 740.
FT /FTId=PRO_0000251402.
FT ZN_FING 88 110 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 116 138 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 144 166 C2H2-type 3; atypical.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT MOD_RES 19 19 Phosphoserine.
FT {ECO:0000244|PubMed:19144319}.
FT VAR_SEQ 1 63 Missing (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_020756.
FT VAR_SEQ 29 40 Missing (in isoform 2).
FT {ECO:0000303|PubMed:16141072}.
FT /FTId=VSP_020757.
FT VAR_SEQ 64 70 SKKTVKK -> MPDCCPQ (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_020758.
FT CONFLICT 8 8 S -> T (in Ref. 1; BAE26025).
FT {ECO:0000305}.
FT CONFLICT 154 154 S -> P (in Ref. 1; BAE26025).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 144 171 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 144 164 ismart:ZnF_C2H2 [T]
FT MYHIT 116 143 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 116 138 ismart:ZnF_C2H2 [T]
FT MYHIT 88 110 ismart:ZnF_C2H2 [T]
FT MYHIT 88 115 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 90 110 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 118 138 ipat:ZINC_FINGER_C2H2_1 [T]
SQ SEQUENCE 180 AA; 20892 MW; DE801DFFC2C98BCE CRC64;
MMLSQIASKQ AENGERAGSP DVLRCSSQMD CKPRFDLSSK GHRKDSDKSR NRKEDDSLAE
ASHSKKTVKK VVVVEQNGSF QVKIPKNFIC EHCFGAFRSS YHLKRHVLIH TGEKPFECDV
CDMRFIQKYH LERHKRVHSG EKPYQCERCH QCFSRTDRLL RHKRMCQGCQ SKTSEGQFSL
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