Legends: 1, KRAB. {ECO:0000255|PROSITE- ProRule:PRU00119}; 2, ZN_FING C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042}; 3, ZN_FING C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042}; 4, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 4; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 6, ZN_FING C2H2-type 5; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 7, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ZN_FING C2H2-type 13. {ECO:0000255|PROSITE- ProRule:PRU00042}; 15, ZN_FING C2H2-type 14. {ECO:0000255|PROSITE- ProRule:PRU00042}; 16, ZN_FING C2H2-type 15. {ECO:0000255|PROSITE- ProRule:PRU00042}; 17, ZN_FING C2H2-type 16. {ECO:0000255|PROSITE- ProRule:PRU00042}; 18, ZN_FING C2H2-type 17. {ECO:0000255|PROSITE- ProRule:PRU00042}; 19, ZN_FING C2H2-type 18. {ECO:0000255|PROSITE- ProRule:PRU00042}; 20, ZN_FING C2H2-type 19. {ECO:0000255|PROSITE- ProRule:PRU00042}; 21, ZN_FING C2H2-type 20. {ECO:0000255|PROSITE- ProRule:PRU00042}; 22, ZN_FING C2H2-type 21. {ECO:0000255|PROSITE- ProRule:PRU00042}; 23, ZN_FING C2H2-type 22. {ECO:0000255|PROSITE- ProRule:PRU00042}; 24, ZN_FING C2H2-type 23; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 25, ismart:ZnF_C2H2 [T]; 26, ipat:ZINC_FINGER_C2H2_1 [T]; 27, iprf:ZINC_FINGER_C2H2_2 [T]; 28, ismart:KRAB [T]; 29, iprf:KRAB [T]; 30, ipfam:KRAB [T].
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ID ZN728_MOUSE Reviewed; 752 AA.
AC Q6P5C7;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 10-MAY-2017, entry version 118.
DE RecName: Full=Zinc finger protein 728;
GN Name=Znf728; Synonyms=Zfp458;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AC159264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC163667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC062958; AAH62958.1; -; mRNA.
DR CCDS; CCDS36710.1; -.
DR RefSeq; NP_001001152.1; NM_001001152.2.
DR UniGene; Mm.306358; -.
DR ProteinModelPortal; Q6P5C7; -.
DR SMR; Q6P5C7; -.
DR STRING; 10090.ENSMUSP00000047222; -.
DR PhosphoSitePlus; Q6P5C7; -.
DR PaxDb; Q6P5C7; -.
DR PRIDE; Q6P5C7; -.
DR Ensembl; ENSMUST00000045969; ENSMUSP00000047222; ENSMUSG00000055480.
DR GeneID; 238690; -.
DR KEGG; mmu:238690; -.
DR UCSC; uc007ral.1; mouse.
DR CTD; 238690; -.
DR MGI; MGI:3040691; Zfp458.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00790000122969; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q6P5C7; -.
DR KO; K09228; -.
DR OMA; YHSEVCG; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q6P5C7; -.
DR TreeFam; TF343410; -.
DR PRO; PR:Q6P5C7; -.
DR Proteomes; UP000000589; Chromosome 13.
DR Bgee; ENSMUSG00000055480; -.
DR Genevisible; Q6P5C7; MM.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 21.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 20.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 2: Evidence at transcript level;
KW Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1 752 Zinc finger protein 728.
FT /FTId=PRO_0000421024.
FT DOMAIN 5 76 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 81 103 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 109 131 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 137 159 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 165 187 C2H2-type 4; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 193 215 C2H2-type 5; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 221 243 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 249 271 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 277 299 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 305 327 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 333 355 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 361 383 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 389 411 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 417 439 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 445 467 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 473 495 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 501 523 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 529 551 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 557 579 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 585 607 C2H2-type 19. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 641 663 C2H2-type 20. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 669 691 C2H2-type 21. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 697 719 C2H2-type 22. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 725 747 C2H2-type 23; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 81 103 ismart:ZnF_C2H2 [T]
FT MYHIT 559 579 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 473 500 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 193 215 ismart:ZnF_C2H2 [T]
FT MYHIT 725 752 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 361 388 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 699 719 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 389 411 ismart:ZnF_C2H2 [T]
FT MYHIT 417 444 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 279 299 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 251 271 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 305 327 ismart:ZnF_C2H2 [T]
FT MYHIT 333 355 ismart:ZnF_C2H2 [T]
FT MYHIT 193 220 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 557 584 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 587 607 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 445 467 ismart:ZnF_C2H2 [T]
FT MYHIT 137 159 ismart:ZnF_C2H2 [T]
FT MYHIT 501 528 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 447 467 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 221 243 ismart:ZnF_C2H2 [T]
FT MYHIT 333 360 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 249 271 ismart:ZnF_C2H2 [T]
FT MYHIT 363 383 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 529 551 ismart:ZnF_C2H2 [T]
FT MYHIT 671 691 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 165 192 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 5 65 ismart:KRAB [T]
FT MYHIT 277 304 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 445 472 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 389 416 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 641 663 ismart:ZnF_C2H2 [T]
FT MYHIT 501 523 ismart:ZnF_C2H2 [T]
FT MYHIT 641 668 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 5 76 iprf:KRAB [T]
FT MYHIT 697 724 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 475 495 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 109 136 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 669 691 ismart:ZnF_C2H2 [T]
FT MYHIT 361 383 ismart:ZnF_C2H2 [T]
FT MYHIT 305 332 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 585 607 ismart:ZnF_C2H2 [T]
FT MYHIT 137 164 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 557 579 ismart:ZnF_C2H2 [T]
FT MYHIT 111 131 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 697 719 ismart:ZnF_C2H2 [T]
FT MYHIT 643 663 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 503 523 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 5 45 ipfam:KRAB [T]
FT MYHIT 529 556 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 419 439 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 139 159 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 305 327 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 531 551 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 223 243 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 221 248 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 417 439 ismart:ZnF_C2H2 [T]
FT MYHIT 391 411 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 473 495 ismart:ZnF_C2H2 [T]
FT MYHIT 585 612 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 109 131 ismart:ZnF_C2H2 [T]
FT MYHIT 335 355 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 669 696 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 277 299 ismart:ZnF_C2H2 [T]
FT MYHIT 83 103 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 81 108 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 249 276 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 752 AA; 86422 MW; 089C07C95BE43A3A CRC64;
MEDMLSFWDV AIYFSAEEWE CLGPAQWKLY RDVMLENYSN LVFLGLASSK PYLVTFLEQI
QEPSDVKRQA AITVHPGGKC YTCKECGKGF EHKKVYQNHR RIHLRVKSYK CEECGKSFRF
PSLLSAHKRN HTGQKPYNCE ICSKAFHVPS LLSVHKRIHR VQKPYKSEDY GKTLHCPSLL
SQHKIVHTGE KPYQCEDLGK AFRYPSRLSN HKKIHTGEKP HKCEVCGKAF DYPSRLSNHK
RIHTGEKPYK CEVCGKAFHD PSKLSQHKII HTGEKPYKCE VCGKTFHYPS ILSKHKIIHT
KENLCKCDIC GKAFHYPLLL SQHKIVHTGE KPYKCEDCGK AFYYPSRLSR HKKIHTGEKP
YKCEVCGKAF YYLSILSKHM IVHTEENPYK CEVCGKAFDY PSRLSNHKKI HTEDKPHKCE
VCGNAFCFSS SLRKHKIIHT GEKPYKCDIC GKAFGSPSRL SKHNKIHTED KPYKCEVCGK
AFHFPSLLLV HKRIHTGEKP YKCEVCGKAF YCLSTLSVHK RIHTGEYAYK CEVCGKAFHC
LSTLSVHKRI HTQEKPYKCE VCGQAFHASS KLSHHKRIHS GEKPHKCEIC GKSFYYPSRL
SKHKVIHTGE KPYHSQASGK TLDYPSRHSK PKTIKTGEKP NKCEICGKAF SFPSLLSIHK
RIHIGEKPYN CEVCGKAFRN PSRLSNHKKI HTGEKPYKCE ICGKAFDYPS LLSKHKIIHT
GEKPYHSEVC GKAFSYSSRI SKDKKICTGE KP
//
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