ID ZN728_HUMAN Reviewed; 622 AA.
AC P0DKX0;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 10-MAY-2017, entry version 38.
DE RecName: Full=Zinc finger protein 728;
GN Name=ZNF728;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
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DR EMBL; AC011502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC074135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59370.1; -.
DR RefSeq; NP_001254645.1; NM_001267716.1.
DR UniGene; Hs.616766; -.
DR ProteinModelPortal; P0DKX0; -.
DR SMR; P0DKX0; -.
DR STRING; 9606.ENSP00000471593; -.
DR iPTMnet; P0DKX0; -.
DR PhosphoSitePlus; P0DKX0; -.
DR BioMuta; ZNF728; -.
DR DMDM; 449061972; -.
DR EPD; P0DKX0; -.
DR MaxQB; P0DKX0; -.
DR PaxDb; P0DKX0; -.
DR PeptideAtlas; P0DKX0; -.
DR PRIDE; P0DKX0; -.
DR Ensembl; ENST00000594710; ENSP00000471593; ENSG00000269067.
DR GeneID; 388523; -.
DR KEGG; hsa:388523; -.
DR UCSC; uc002nqz.3; human.
DR CTD; 388523; -.
DR GeneCards; ZNF728; -.
DR HGNC; HGNC:32463; ZNF728.
DR neXtProt; NX_P0DKX0; -.
DR OpenTargets; ENSG00000269067; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00790000122969; -.
DR InParanoid; P0DKX0; -.
DR OMA; WCTHLTR; -.
DR OrthoDB; EOG091G02KC; -.
DR GenomeRNAi; 388523; -.
DR PRO; PR:P0DKX0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000269067; -.
DR ExpressionAtlas; P0DKX0; baseline and differential.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.40.10; -; 3.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1 622 Zinc finger protein 728.
FT /FTId=PRO_0000421023.
FT DOMAIN 4 75 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 228 250 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 256 278 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 284 306 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 312 334 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 340 362 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 368 390 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 396 418 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 424 446 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 452 474 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 480 502 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 508 530 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 536 558 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 564 586 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 592 614 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 4 64 ismart:KRAB [T]
FT MYHIT 228 250 ismart:ZnF_C2H2 [T]
FT MYHIT 536 558 ismart:ZnF_C2H2 [T]
FT MYHIT 286 306 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 536 563 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 312 334 ismart:ZnF_C2H2 [T]
FT MYHIT 480 502 ismart:ZnF_C2H2 [T]
FT MYHIT 340 362 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 228 250 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 566 586 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 396 423 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 398 418 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 370 390 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 592 614 ismart:ZnF_C2H2 [T]
FT MYHIT 368 390 ismart:ZnF_C2H2 [T]
FT MYHIT 452 474 ismart:ZnF_C2H2 [T]
FT MYHIT 258 278 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 3 44 ipfam:KRAB [T]
FT MYHIT 564 591 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 396 418 ismart:ZnF_C2H2 [T]
FT MYHIT 256 283 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 228 255 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 592 619 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 482 502 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 508 535 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 256 278 ismart:ZnF_C2H2 [T]
FT MYHIT 564 586 ismart:ZnF_C2H2 [T]
FT MYHIT 426 446 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 314 334 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 340 367 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 508 530 ismart:ZnF_C2H2 [T]
FT MYHIT 424 446 ismart:ZnF_C2H2 [T]
FT MYHIT 454 474 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 480 507 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 4 75 iprf:KRAB [T]
FT MYHIT 510 530 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 284 311 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 368 395 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 594 614 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 424 451 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 538 558 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 340 362 ismart:ZnF_C2H2 [T]
FT MYHIT 312 339 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 284 306 ismart:ZnF_C2H2 [T]
FT MYHIT 452 479 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 622 AA; 71801 MW; 3C6857B813210100 CRC64;
MGSLTFRDVA IQFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAPKP DLIIFLEQGK
EPWNMKRHEL VKEPPVICSH FAQDLWPEQG REDSFQKVIL RRYEKCGHEN LQLKIGCTNV
DECKVHKKGY NKLNQSLTTT QSKVFQCGKY ANIFHKCSNS KRHKIRHTGK KLLKCKEYVR
SFCMLSHLSQ HKRIYTRENS YKSEEHGKAF NWSSALTYKR IHTGEKPCKC EECGKAFSKF
SILTKHKVIH TGEKHYKCEE CGKAFTRSSS LIEHKRSHAG EKPYKCEECG KAFSKASTLT
AHKTIHAGEK PYKCEECGKA FNRSSNLMEH KRIHTGEKPC KCEECGKAFG NFSTLTKHKV
IHTGEKPYKC EECGKAFSWP SSLTEHKRIH AGDKPYKCEE CGKTFKWSST LTKHKIIHTG
EKPYKCEECG KAFTTFSSLT KHKVIHTGEK HYKCEECGKV FSWSSSLTTH KAIHAGEKLY
KCEECGKAFK WSSNLMEHKR IHTGEKPYKC EECGKAFSKV ANLTKHKVIH TGEKQYKCEE
CGKAFIWSSR LSEHKRIHTG EKPYKCEECG KAFSWVSVLN KHKKIHAGKK FYKCEECGKD
FNQSSHLTTH KRIHTGGKTL QM
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