ID ZN717_HUMAN Reviewed; 904 AA.
AC Q9BY31;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 10-MAY-2017, entry version 106.
DE RecName: Full=Zinc finger protein 717;
DE AltName: Full=Krueppel-like factor X17;
GN Name=ZNF717;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 386-689.
RC TISSUE=Muscle;
RA Brand N.J., Mullen A.J., Barton P.J.R.;
RT "Identification of C2H2 zinc finger factor sequences in human heart.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK28319.1; Type=Frameshift; Positions=685; Evidence={ECO:0000305};
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DR EMBL; AC108724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC133123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF226994; AAK28319.1; ALT_FRAME; mRNA.
DR UniGene; Hs.556877; -.
DR ProteinModelPortal; Q9BY31; -.
DR SMR; Q9BY31; -.
DR IntAct; Q9BY31; 1.
DR STRING; 9606.ENSP00000409514; -.
DR iPTMnet; Q9BY31; -.
DR PhosphoSitePlus; Q9BY31; -.
DR DMDM; 189041707; -.
DR PaxDb; Q9BY31; -.
DR PeptideAtlas; Q9BY31; -.
DR PRIDE; Q9BY31; -.
DR Ensembl; ENST00000400845; ENSP00000383643; ENSG00000227124.
DR DisGeNET; 100131827; -.
DR GeneCards; ZNF717; -.
DR HGNC; HGNC:29448; ZNF717.
DR neXtProt; NX_Q9BY31; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q9BY31; -.
DR PhylomeDB; Q9BY31; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR PRO; PR:Q9BY31; -.
DR Proteomes; UP000005640; Unplaced.
DR Bgee; ENSG00000227124; -.
DR CleanEx; HS_ZNF717; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 904 Zinc finger protein 717.
FT /FTId=PRO_0000333738.
FT DOMAIN 15 86 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 202 224 C2H2-type 1; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 259 270 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 276 298 C2H2-type 3; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 304 326 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 332 354 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 360 382 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 388 410 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 416 438 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 444 466 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 472 494 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 500 522 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 528 550 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 556 578 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 584 606 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 612 634 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 642 659 C2H2-type 16; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 731 742 C2H2-type 17; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 748 770 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 776 798 C2H2-type 19. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 804 826 C2H2-type 20. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 832 854 C2H2-type 21. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 860 882 C2H2-type 22. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT CONFLICT 664 664 R -> H (in Ref. 2; AAK28319).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 388 415 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 444 466 ismart:ZnF_C2H2 [T]
FT MYHIT 502 522 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 444 471 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 528 555 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 806 826 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 390 410 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 306 326 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 362 382 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 332 359 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 418 438 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 612 639 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 832 859 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 776 803 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 530 550 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 446 466 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 584 606 ismart:ZnF_C2H2 [T]
FT MYHIT 388 410 ismart:ZnF_C2H2 [T]
FT MYHIT 332 354 ismart:ZnF_C2H2 [T]
FT MYHIT 14 55 ipfam:KRAB [T]
FT MYHIT 748 775 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 586 606 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 202 224 ismart:ZnF_C2H2 [T]
FT MYHIT 641 659 ismart:ZnF_C2H2 [T]
FT MYHIT 304 326 ismart:ZnF_C2H2 [T]
FT MYHIT 556 578 ismart:ZnF_C2H2 [T]
FT MYHIT 500 527 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 748 770 ismart:ZnF_C2H2 [T]
FT MYHIT 860 887 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 556 583 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 334 354 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 834 854 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 750 770 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 832 854 ismart:ZnF_C2H2 [T]
FT MYHIT 528 550 ismart:ZnF_C2H2 [T]
FT MYHIT 360 382 ismart:ZnF_C2H2 [T]
FT MYHIT 15 86 iprf:KRAB [T]
FT MYHIT 860 882 ismart:ZnF_C2H2 [T]
FT MYHIT 416 443 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 472 494 ismart:ZnF_C2H2 [T]
FT MYHIT 642 664 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 558 578 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 614 634 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 776 798 ismart:ZnF_C2H2 [T]
FT MYHIT 612 634 ismart:ZnF_C2H2 [T]
FT MYHIT 804 826 ismart:ZnF_C2H2 [T]
FT MYHIT 472 499 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 202 224 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 500 522 ismart:ZnF_C2H2 [T]
FT MYHIT 474 494 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 304 331 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 15 75 ismart:KRAB [T]
FT MYHIT 584 611 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 360 387 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 778 798 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 862 882 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 804 831 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 416 438 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 904 AA; 105251 MW; 8740B06833A76B4A CRC64;
MLETYNSLVS LQELVSFEEV AVHFTWEEWQ DLDDAQRTLY RDVMLETYSS LVSLGHCITK
PEMIFKLEQG AEPWIVEETP NLRLSAVQII DDLIERSHES HDRFFWQIVI TNSNTSTQER
VELGKTFNLN SNHVLNLIIN NGNSSGMKPG QFNDCQNMLF PIKPGETQSG EKPHVCDITR
RSHRHHEHLT QHHKIQTLLQ TFQCNEQGKT FNTEAMFFIH KRVHIVQTFG KYNEYEKACN
NSAVIVQVIT QVGQPTCCRK SDFTKHQQTH TGEKPYECVE CEKPSISKSD LMLQCKMPTE
EKPYACNWCE KLFSYKSSLI IHQRIHTGEK PYGCNECGKT FRRKSFLTLH ERTHTGDKPY
KCIECGKTFH CKSLLTLHHR THSGEKPYQC SECGKTFSQK SYLTIHHRTH TGEKPYACDH
CEEAFSHKSR LTVHQRTHTG EKPYECNECG KPFINKSNLR LHQRTHTGEK PYECNECGKT
FHRKSFLTIH QWTHTGEKPY ECNECGKTFR CKSFLTVHQR THAGEKPYAC NECGKTYSHK
SYLTVHHRTH TGEKPYECNE CGKSFHCKSF LTIHQRTHAG KKPYECNECE KTFINKLNLG
IHKITHTGER PYECNECGKT FRQKSNLSTH QGTHTGEKPY VCGKTFHRKS FLTIHQRTHT
GKNRMDVMNV EKLFVRNHTL LYIRELTPGK SPMNVMNVEN PFIRRQIFRS IKVFTRGRNP
MNVANVEKPC QKSVLTVHHR THTGEKPYEC NECGKTFCHK SNLSTHQGTH SGEKPYECDE
CRKTFYDKTV LTIHQRTHTG EKPFECKECR KTFSQKSKLF VHHRTHTGEK PFRCNECRKT
FSQKSGLSIH QRTHTGEKPY ECKECGKTFC QKSHLSRHQQ THIGEKSDVA EAGYVFPQNH
SFFP
//
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