ID ZN716_HUMAN Reviewed; 495 AA.
AC A6NP11;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 4.
DT 10-MAY-2017, entry version 85.
DE RecName: Full=Zinc finger protein 716;
GN Name=ZNF716;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK131575; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC092175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55112.1; -.
DR RefSeq; NP_001152751.1; NM_001159279.1.
DR UniGene; Hs.533121; -.
DR ProteinModelPortal; A6NP11; -.
DR SMR; A6NP11; -.
DR BioGrid; 137285; 1.
DR STRING; 9606.ENSP00000394248; -.
DR iPTMnet; A6NP11; -.
DR PhosphoSitePlus; A6NP11; -.
DR BioMuta; ZNF716; -.
DR EPD; A6NP11; -.
DR MaxQB; A6NP11; -.
DR PaxDb; A6NP11; -.
DR PRIDE; A6NP11; -.
DR Ensembl; ENST00000420713; ENSP00000394248; ENSG00000182111.
DR GeneID; 441234; -.
DR KEGG; hsa:441234; -.
DR UCSC; uc011kdi.2; human.
DR CTD; 441234; -.
DR GeneCards; ZNF716; -.
DR HGNC; HGNC:32458; ZNF716.
DR neXtProt; NX_A6NP11; -.
DR OpenTargets; ENSG00000182111; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00790000122969; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; A6NP11; -.
DR KO; K09228; -.
DR OMA; VKKCCKS; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; A6NP11; -.
DR TreeFam; TF342117; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 441234; -.
DR PRO; PR:A6NP11; -.
DR Proteomes; UP000005640; Chromosome 7.
DR CleanEx; HS_ZNF716; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 495 Zinc finger protein 716.
FT /FTId=PRO_0000318855.
FT DOMAIN 16 87 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 157 179 C2H2-type 1; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 185 207 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 213 235 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 241 263 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 269 290 C2H2-type 5; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 296 318 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 324 346 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 352 374 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 380 402 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 408 430 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 436 458 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 464 486 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 324 351 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 352 379 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 436 463 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 213 240 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 354 374 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 324 346 ismart:ZnF_C2H2 [T]
FT MYHIT 298 318 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 408 430 ismart:ZnF_C2H2 [T]
FT MYHIT 269 295 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 185 207 ismart:ZnF_C2H2 [T]
FT MYHIT 464 486 ismart:ZnF_C2H2 [T]
FT MYHIT 380 402 ismart:ZnF_C2H2 [T]
FT MYHIT 464 491 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 241 263 ismart:ZnF_C2H2 [T]
FT MYHIT 438 458 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 466 486 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 241 268 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 326 346 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 296 318 ismart:ZnF_C2H2 [T]
FT MYHIT 380 407 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 16 76 ismart:KRAB [T]
FT MYHIT 213 235 ismart:ZnF_C2H2 [T]
FT MYHIT 382 402 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 243 263 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 410 430 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 408 435 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 436 458 ismart:ZnF_C2H2 [T]
FT MYHIT 15 56 ipfam:KRAB [T]
FT MYHIT 296 323 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 157 184 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 16 87 iprf:KRAB [T]
FT MYHIT 215 235 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 352 374 ismart:ZnF_C2H2 [T]
FT MYHIT 185 212 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 495 AA; 57006 MW; 0EDE6E44362C630A CRC64;
MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR NLVSLGIAVS
KPDLITCLEQ NKEPQNIKRN EMVAKHPVTC SHFTQDLQSE QGIKDSLQKV ILRRYGKCGQ
EDLQVKKCCK SVGECEVHKG GYNYVNQCLS ATQNKTFQTH KCVKVFGKFS NSNRHKTRHT
GKKHFKCKND GKSFCMLSRL NQHQIIHTRE KSYKCEECGK SFNCSSTLTR HKRIHTGEKP
YRCEECGKAF SWSASLTKHK RIHTGEKPYT CEERGKVFSR STLTNYKRIH TGEKPYTCEE
CGKAFSRSST LTNHKRIHTG ERPYKCEECG KAFSLSSTLK KHKIVHTGEK LYTCEECGKA
FTFSSTLNTH KRIHTGEKPY TCEECGKAFS LPSTFTYHKR THTGEKPYKC EECGKAFNCS
STLKKHKIIH TGEKLYKCKE CGKAFTFSST LNTHKRIHTG EKPYKCEECD QTFKWHSSLA
NHKNMHTGEK PYKYE
//
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