ID ZN671_HUMAN Reviewed; 534 AA.
AC Q8TAW3; A6NF07; Q9H5E9;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 10-MAY-2017, entry version 131.
DE RecName: Full=Zinc finger protein 671;
GN Name=ZNF671;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-149.
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH25728.1; Type=Frameshift; Positions=534; Evidence={ECO:0000305};
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DR EMBL; AK027159; BAB15677.1; -; mRNA.
DR EMBL; AC003006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72529.1; -; Genomic_DNA.
DR EMBL; BC025728; AAH25728.1; ALT_FRAME; mRNA.
DR CCDS; CCDS12961.1; -.
DR RefSeq; NP_079109.2; NM_024833.2.
DR UniGene; Hs.180402; -.
DR ProteinModelPortal; Q8TAW3; -.
DR SMR; Q8TAW3; -.
DR BioGrid; 122975; 2.
DR IntAct; Q8TAW3; 1.
DR MINT; MINT-8247557; -.
DR STRING; 9606.ENSP00000321848; -.
DR iPTMnet; Q8TAW3; -.
DR PhosphoSitePlus; Q8TAW3; -.
DR BioMuta; ZNF671; -.
DR DMDM; 229462791; -.
DR MaxQB; Q8TAW3; -.
DR PaxDb; Q8TAW3; -.
DR PeptideAtlas; Q8TAW3; -.
DR PRIDE; Q8TAW3; -.
DR DNASU; 79891; -.
DR Ensembl; ENST00000317398; ENSP00000321848; ENSG00000083814.
DR GeneID; 79891; -.
DR KEGG; hsa:79891; -.
DR UCSC; uc002qpz.5; human.
DR CTD; 79891; -.
DR DisGeNET; 79891; -.
DR GeneCards; ZNF671; -.
DR HGNC; HGNC:26279; ZNF671.
DR HPA; HPA046099; -.
DR neXtProt; NX_Q8TAW3; -.
DR OpenTargets; ENSG00000083814; -.
DR PharmGKB; PA142670518; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119107; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8TAW3; -.
DR KO; K09228; -.
DR PhylomeDB; Q8TAW3; -.
DR TreeFam; TF342033; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 79891; -.
DR PRO; PR:Q8TAW3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000083814; -.
DR CleanEx; HS_ZNF671; -.
DR ExpressionAtlas; Q8TAW3; baseline and differential.
DR Genevisible; Q8TAW3; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 534 Zinc finger protein 671.
FT /FTId=PRO_0000233990.
FT DOMAIN 49 120 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 192 214 C2H2-type 1; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 285 307 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 313 335 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 341 363 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 369 391 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 397 419 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 425 447 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 451 473 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 479 501 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 507 529 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VARIANT 149 149 A -> V (in dbSNP:rs3746207).
FT {ECO:0000269|PubMed:14702039}.
FT /FTId=VAR_026151.
FT VARIANT 237 237 P -> S (in dbSNP:rs34419645).
FT /FTId=VAR_055240.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 313 340 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 369 396 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 313 335 ismart:ZnF_C2H2 [T]
FT MYHIT 451 473 ismart:ZnF_C2H2 [T]
FT MYHIT 192 219 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 371 391 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 509 529 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 341 363 ismart:ZnF_C2H2 [T]
FT MYHIT 343 363 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 397 424 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 49 109 ismart:KRAB [T]
FT MYHIT 507 529 ismart:ZnF_C2H2 [T]
FT MYHIT 49 120 iprf:KRAB [T]
FT MYHIT 479 501 ismart:ZnF_C2H2 [T]
FT MYHIT 397 419 ismart:ZnF_C2H2 [T]
FT MYHIT 399 419 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 287 307 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 507 534 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 315 335 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 369 391 ismart:ZnF_C2H2 [T]
FT MYHIT 453 473 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 285 312 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 285 307 ismart:ZnF_C2H2 [T]
FT MYHIT 427 447 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 341 368 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 425 452 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 451 478 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 481 501 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 425 447 ismart:ZnF_C2H2 [T]
FT MYHIT 49 89 ipfam:KRAB [T]
FT MYHIT 479 506 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 534 AA; 60972 MW; 701BC2C02BC95124 CRC64;
MLSPVSRDAS DALQGRKCLR PRSRRLPLPA AVRAHGPMAE LTDSARGCVV FEDVFVYFSR
EEWELLDDAQ RLLYHDVMLE NFALLASLGI AFSRSRAVMK LERGEEPWVY DQVDMTSATE
REAQRGLRPG CWHGVEDEEV SSEQSIFVAG VSEVRTLMAE LESHPCDICG PILKDTLHLA
KYHGGKARQK PYLCGACGKQ FWFSTDFDQH QNQPNGGKLF PRKEGRDSVK SCRVHVPEKT
LTCGKGRRDF SATSGLLQHQ ASLSSMKPHK STKLVSGFLM GQRYHRCGEC GKAFTRKDTL
ARHQRIHTGE RPYECNECGK FFSQSYDLFK HQTVHTGERP YECSECGKFF RQISGLIEHR
RVHTGERLYQ CGKCGKFFSS KSNLIRHQEV HTGARPYVCS ECGKEFSRKH TLVLHQRTHT
GERPYECSEC GKAFSQSSHL NVHWRIHSSD YECSRCGKAF SCISKLIQHQ KVHSGEKPYE
CSKCGKAFTQ RPNLIRHWKV HTGERPYVCS ECGREFIRKQ TLVLHQRVHA GEKL
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