Entry euk:ZN623_HUMAN

ID   ZN623_HUMAN             Reviewed;         536 AA.
AC   O75123; A4FU80; B4DGP3; E7ENV5;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   10-MAY-2017, entry version 144.
DE   RecName: Full=Zinc finger protein 623;
GN   Name=ZNF623; Synonyms=KIAA0628;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   ASP-126.
RC   TISSUE=Brain;
RX   PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA   Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA   Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. X.
RT   The complete sequences of 100 new cDNA clones from brain which can
RT   code for large proteins in vitro.";
RL   DNA Res. 5:169-176(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   ASP-126.
RC   TISSUE=Brain, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O75123-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O75123-2; Sequence=VSP_053501;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA31603.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC       Sequence=BAG57854.1; Type=Frameshift; Positions=467; Evidence={ECO:0000305};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB014528; BAA31603.2; ALT_INIT; mRNA.
DR   EMBL; AK294695; BAG57854.1; ALT_FRAME; mRNA.
DR   EMBL; AC067930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC067516; AAH67516.1; -; mRNA.
DR   EMBL; BC067517; AAH67517.1; -; mRNA.
DR   EMBL; BC067518; AAH67518.1; -; mRNA.
DR   EMBL; BC075056; AAH75056.1; -; mRNA.
DR   EMBL; BC075057; AAH75057.1; -; mRNA.
DR   EMBL; BC112899; AAI12900.1; -; mRNA.
DR   CCDS; CCDS34957.1; -. [O75123-1]
DR   CCDS; CCDS47931.1; -. [O75123-2]
DR   RefSeq; NP_001075949.1; NM_001082480.2.
DR   RefSeq; NP_001248772.1; NM_001261843.1.
DR   RefSeq; NP_055604.3; NM_014789.3.
DR   UniGene; Hs.43133; -.
DR   UniGene; Hs.694018; -.
DR   UniGene; Hs.745418; -.
DR   ProteinModelPortal; O75123; -.
DR   SMR; O75123; -.
DR   BioGrid; 115169; 4.
DR   STRING; 9606.ENSP00000434258; -.
DR   iPTMnet; O75123; -.
DR   PhosphoSitePlus; O75123; -.
DR   BioMuta; ZNF623; -.
DR   EPD; O75123; -.
DR   MaxQB; O75123; -.
DR   PaxDb; O75123; -.
DR   PeptideAtlas; O75123; -.
DR   PRIDE; O75123; -.
DR   DNASU; 9831; -.
DR   Ensembl; ENST00000501748; ENSP00000445979; ENSG00000183309.
DR   GeneID; 9831; -.
DR   KEGG; hsa:9831; -.
DR   UCSC; uc003yzd.3; human. [O75123-1]
DR   CTD; 9831; -.
DR   GeneCards; ZNF623; -.
DR   HGNC; HGNC:29084; ZNF623.
DR   HPA; HPA044372; -.
DR   neXtProt; NX_O75123; -.
DR   PharmGKB; PA134969295; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; O75123; -.
DR   KO; K09228; -.
DR   OrthoDB; EOG091G02KC; -.
DR   PhylomeDB; O75123; -.
DR   TreeFam; TF337005; -.
DR   ChiTaRS; ZNF623; human.
DR   GenomeRNAi; 9831; -.
DR   PRO; PR:O75123; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000183309; -.
DR   CleanEx; HS_ZNF623; -.
DR   ExpressionAtlas; O75123; baseline and differential.
DR   Genevisible; O75123; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    536       Zinc finger protein 623.
FT                                /FTId=PRO_0000047694.
FT   ZN_FING     123    145       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     151    173       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     179    201       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     207    229       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     235    257       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     263    285       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     291    313       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     319    341       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     347    369       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     375    397       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     403    425       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     431    453       C2H2-type 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     459    481       C2H2-type 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VAR_SEQ       1     40       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_053501.
FT   VARIANT     126    126       N -> D (in dbSNP:rs4874084).
FT                                {ECO:0000269|PubMed:15489334,
FT                                ECO:0000269|PubMed:9734811}.
FT                                /FTId=VAR_052881.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       403    425       ismart:ZnF_C2H2 [T]
FT   MYHIT       405    425       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       207    234       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       321    341       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       151    178       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       123    145       ismart:ZnF_C2H2 [T]
FT   MYHIT       459    481       ismart:ZnF_C2H2 [T]
FT   MYHIT       179    206       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       377    397       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       375    402       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       265    285       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       209    229       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       179    201       ismart:ZnF_C2H2 [T]
FT   MYHIT       459    486       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       207    229       ismart:ZnF_C2H2 [T]
FT   MYHIT       181    201       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       291    318       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       319    346       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       433    453       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       237    257       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       431    453       ismart:ZnF_C2H2 [T]
FT   MYHIT       263    285       ismart:ZnF_C2H2 [T]
FT   MYHIT       291    313       ismart:ZnF_C2H2 [T]
FT   MYHIT       235    257       ismart:ZnF_C2H2 [T]
FT   MYHIT       347    374       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       263    290       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       347    369       ismart:ZnF_C2H2 [T]
FT   MYHIT       235    262       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       461    481       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       293    313       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       431    458       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       375    397       ismart:ZnF_C2H2 [T]
FT   MYHIT       349    369       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       151    173       ismart:ZnF_C2H2 [T]
FT   MYHIT       123    150       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       125    145       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       403    430       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       153    173       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       319    341       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   536 AA;  61392 MW;  798EB7EC0F0A4366 CRC64;
     MILLSFVSDS NVGTGEKKVT EAWISEDENS HRTTSDRLTV MELPSPESEE VHEPRLGELL
     GNPEGQSLGS SPSQDRGCKQ VTVTHWKIQT GETAQVCTKS GRNHILNSDL LLLQRELIEG
     EANPCNICGK TFTFNSDLVR HRISHAGEKP YTCDQCGKGF GQSSHLMEHQ RIHTGERLYV
     CNVCGKDFIH YSGLIEHQRV HSGEKPFKCA QCGKAFCHSS DLIRHQRVHT RERPFECKEC
     GKGFSQSSLL IRHQRIHTGE RPYECNECGK SFIRSSSLIR HYQIHTEVKQ YECKECGKAF
     RHRSDLIEHQ RIHTGERPFE CNECGKAFIR SSKLIQHQRI HTGERPYVCN ECGKRFSQTS
     NFTQHQRIHT GEKLYECNEC GKAFFLSSYL IRHQKIHTGE RVYECKECGK AFLQKAHLTE
     HQKIHSGDRP FECKDCGKAF IQSSKLLLHQ IIHTGEKPYV CSYCGKGFIQ RSNFLQHQKI
     HTEEKLYECS QYGRDFNSTT NVKNNQRVHQ EGLSLSKAPI HLGERSVDKG EHTGNL
//