ID ZN540_HUMAN Reviewed; 660 AA.
AC Q8NDQ6; A0AVS5; A8K371; Q05D58; Q3LIC5; Q6ZN36; Q7Z3C8; Q86T31;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 10-MAY-2017, entry version 128.
DE RecName: Full=Zinc finger protein 540;
GN Name=ZNF540; ORFNames=Nbla10512;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT
RP VAL-53.
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Heart;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-660.
RC TISSUE=Neuroblastoma;
RX PubMed=12880961; DOI=10.1016/S0304-3835(03)00085-5;
RA Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S.,
RA Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S.,
RA Hirato J., Nakagawara A.;
RT "Neuroblastoma oligo-capping cDNA project: toward the understanding of
RT the genesis and biology of neuroblastoma.";
RL Cancer Lett. 197:63-68(2003).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MVP, AND TISSUE
RP SPECIFICITY.
RX PubMed=16815308; DOI=10.1016/j.bbrc.2006.06.076;
RA Xiang Z., Yuan W., Luo N., Wang Y., Tan K., Deng Y., Zhou X., Zhu C.,
RA Li Y., Liu M., Wu X., Li Y.;
RT "A novel human zinc finger protein ZNF540 interacts with MVP and
RT inhibits transcriptional activities of the ERK signal pathway.";
RL Biochem. Biophys. Res. Commun. 347:288-296(2006).
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] ILE-275.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
RN [7]
RP VARIANT ARG-340.
RX PubMed=23033978; DOI=10.1056/NEJMoa1206524;
RA de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G.,
RA Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P.,
RA Gilissen C., del Rosario M., Hoischen A., Scheffer H., de Vries B.B.,
RA Brunner H.G., Veltman J.A., Vissers L.E.;
RT "Diagnostic exome sequencing in persons with severe intellectual
RT disability.";
RL N. Engl. J. Med. 367:1921-1929(2012).
CC -!- FUNCTION: May act as a transcriptional repressor.
CC {ECO:0000269|PubMed:16815308}.
CC -!- SUBUNIT: May interact with MVP.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16815308}.
CC Cytoplasm {ECO:0000269|PubMed:16815308}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NDQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDQ6-2; Sequence=VSP_016037;
CC Note=No experimental confirmation available.;
CC Name=4;
CC IsoId=Q8NDQ6-4; Sequence=VSP_016036;
CC Note=No experimental confirmation available.;
CC -!- TISSUE SPECIFICITY: Expressed in several fetal tissues, including
CC gut, heart, brain, muscle, lung, testis and liver.
CC {ECO:0000269|PubMed:16815308}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17940.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=CAD97942.1; Type=Frameshift; Positions=580; Evidence={ECO:0000305};
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DR EMBL; AK131388; BAD18539.1; -; mRNA.
DR EMBL; AK290486; BAF83175.1; -; mRNA.
DR EMBL; AL832100; CAD91161.1; -; mRNA.
DR EMBL; AL832315; CAD38611.1; -; mRNA.
DR EMBL; BX537980; CAD97942.1; ALT_FRAME; mRNA.
DR EMBL; BC017940; AAH17940.1; ALT_SEQ; mRNA.
DR EMBL; BC126478; AAI26479.1; -; mRNA.
DR EMBL; BC126480; AAI26481.1; -; mRNA.
DR EMBL; AB074186; BAE45743.1; -; mRNA.
DR CCDS; CCDS12506.1; -. [Q8NDQ6-1]
DR CCDS; CCDS54258.1; -. [Q8NDQ6-2]
DR RefSeq; NP_001165696.1; NM_001172225.2. [Q8NDQ6-1]
DR RefSeq; NP_001165697.1; NM_001172226.2. [Q8NDQ6-2]
DR RefSeq; NP_689819.1; NM_152606.4. [Q8NDQ6-1]
DR UniGene; Hs.728927; -.
DR ProteinModelPortal; Q8NDQ6; -.
DR SMR; Q8NDQ6; -.
DR STRING; 9606.ENSP00000324598; -.
DR iPTMnet; Q8NDQ6; -.
DR PhosphoSitePlus; Q8NDQ6; -.
DR BioMuta; ZNF540; -.
DR DMDM; 74762556; -.
DR PaxDb; Q8NDQ6; -.
DR PeptideAtlas; Q8NDQ6; -.
DR PRIDE; Q8NDQ6; -.
DR DNASU; 163255; -.
DR Ensembl; ENST00000316433; ENSP00000324598; ENSG00000171817. [Q8NDQ6-1]
DR Ensembl; ENST00000343599; ENSP00000343768; ENSG00000171817. [Q8NDQ6-1]
DR Ensembl; ENST00000589117; ENSP00000467118; ENSG00000171817. [Q8NDQ6-2]
DR Ensembl; ENST00000592533; ENSP00000466274; ENSG00000171817. [Q8NDQ6-1]
DR GeneID; 163255; -.
DR KEGG; hsa:163255; -.
DR UCSC; uc002ogq.5; human. [Q8NDQ6-1]
DR CTD; 163255; -.
DR GeneCards; ZNF540; -.
DR HGNC; HGNC:25331; ZNF540.
DR HPA; HPA003444; -.
DR MIM; 613903; gene.
DR neXtProt; NX_Q8NDQ6; -.
DR OpenTargets; ENSG00000171817; -.
DR PharmGKB; PA134980975; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00840000129704; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8NDQ6; -.
DR KO; K09228; -.
DR OMA; RGQLNRH; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q8NDQ6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 163255; -.
DR PRO; PR:Q8NDQ6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000171817; -.
DR CleanEx; HS_ZNF540; -.
DR ExpressionAtlas; Q8NDQ6; baseline and differential.
DR Genevisible; Q8NDQ6; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000900; F:translation repressor activity, nucleic acid binding; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0017148; P:negative regulation of translation; IMP:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 17.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm; DNA-binding;
KW Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 660 Zinc finger protein 540.
FT /FTId=PRO_0000047641.
FT DOMAIN 6 77 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 187 209 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 215 237 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 243 265 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 271 293 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 299 321 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 327 349 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 355 377 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 383 405 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 411 433 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 439 461 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 467 489 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 495 517 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 523 545 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 551 573 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 579 601 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 607 629 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 635 657 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 1 77 MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNN
FT LVSLGYSGSKPDVITLLEQGKEPCVVARDVTGRQCP -> M
FT LPNFKLYNFIEIFFKPLTPSKNRFHFVSYFENVNFMLCWLQ
FT ENNFCLLLCFLS (in isoform 4).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_016036.
FT VAR_SEQ 46 77 Missing (in isoform 2).
FT {ECO:0000303|PubMed:17974005}.
FT /FTId=VSP_016037.
FT VARIANT 53 53 D -> V (in dbSNP:rs1975937).
FT {ECO:0000269|PubMed:14702039}.
FT /FTId=VAR_033575.
FT VARIANT 275 275 K -> I (in a colorectal cancer sample;
FT somatic mutation).
FT {ECO:0000269|PubMed:16959974}.
FT /FTId=VAR_035586.
FT VARIANT 340 340 G -> R (in dbSNP:rs571893947).
FT {ECO:0000269|PubMed:23033978}.
FT /FTId=VAR_069366.
FT CONFLICT 127 127 E -> G (in Ref. 2; CAD97942).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 579 601 ismart:ZnF_C2H2 [T]
FT MYHIT 609 629 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 243 270 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 357 377 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 467 489 ismart:ZnF_C2H2 [T]
FT MYHIT 189 209 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 271 293 ismart:ZnF_C2H2 [T]
FT MYHIT 523 550 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 551 573 ismart:ZnF_C2H2 [T]
FT MYHIT 273 293 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 329 349 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 581 601 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 5 46 ipfam:KRAB [T]
FT MYHIT 495 517 ismart:ZnF_C2H2 [T]
FT MYHIT 413 433 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 607 629 ismart:ZnF_C2H2 [T]
FT MYHIT 495 522 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 383 405 ismart:ZnF_C2H2 [T]
FT MYHIT 579 606 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 187 214 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 497 517 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 271 298 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 187 209 ismart:ZnF_C2H2 [T]
FT MYHIT 355 377 ismart:ZnF_C2H2 [T]
FT MYHIT 245 265 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 411 433 ismart:ZnF_C2H2 [T]
FT MYHIT 607 634 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 301 321 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 299 321 ismart:ZnF_C2H2 [T]
FT MYHIT 327 354 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 385 405 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 243 265 ismart:ZnF_C2H2 [T]
FT MYHIT 523 545 ismart:ZnF_C2H2 [T]
FT MYHIT 327 349 ismart:ZnF_C2H2 [T]
FT MYHIT 467 494 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 525 545 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 635 660 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 553 573 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 215 237 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 635 657 ismart:ZnF_C2H2 [T]
FT MYHIT 411 438 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 439 461 ismart:ZnF_C2H2 [T]
FT MYHIT 355 382 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 215 237 ismart:ZnF_C2H2 [T]
FT MYHIT 469 489 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 439 466 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 637 657 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 551 578 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 6 77 iprf:KRAB [T]
FT MYHIT 441 461 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 383 410 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 215 242 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 299 326 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 6 66 ismart:KRAB [T]
SQ SEQUENCE 660 AA; 77094 MW; 9115ABB3B056D9B3 CRC64;
MAHALVTFRD VAIDFSQKEW ECLDTTQRKL YRDVMLENYN NLVSLGYSGS KPDVITLLEQ
GKEPCVVARD VTGRQCPGLL SRHKTKKLSS EKDIHEISLS KESIIEKSKT LRLKGSIFRN
EWQNKSEFEG QQGLKERSIS QKKIVSKKMS TDRKRPSFTL NQRIHNSEKS CDSHLVQHGK
IDSDVKHDCK ECGSTFNNVY QLTLHQKIHT GEKSCKCEKC GKVFSHSYQL TLHQRFHTGE
KPYECQECGK TFTLYPQLNR HQKIHTGKKP YMCKKCDKGF FSRLELTQHK RIHTGKKSYE
CKECGKVFQL IFYFKEHERI HTGKKPYECK ECGKAFSVCG QLTRHQKIHT GVKPYECKEC
GKTFRLSFYL TEHRRTHAGK KPYECKECGK SFNVRGQLNR HKTIHTGIKP FACKVCEKAF
SYSGDLRVHS RIHTGEKPYE CKECGKAFML RSVLTEHQRL HTGVKPYECK ECGKTFRVRS
QISLHKKIHT DVKPYKCVRC GKTFRFGFYL TEHQRIHTGE KPYKCKECGK AFIRRGNLKE
HLKIHSGLKP YDCKECGKSF SRRGQFTEHQ KIHTGVKPYK CKECGKAFSR SVDLRIHQRI
HTGEKPYECK QCGKAFRLNS HLTEHQRIHT GEKPYECKVC RKAFRQYSHL YQHQKTHNVI
//
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