Entry euk:ZN526_HUMAN

ID   ZN526_HUMAN             Reviewed;         670 AA.
AC   Q8TF50; B3KV29; Q69YI2; Q96E24;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   10-MAY-2017, entry version 111.
DE   RecName: Full=Zinc finger protein 526;
GN   Name=ZNF526; Synonyms=KIAA1951;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XXII.
RT   The complete sequences of 50 new cDNA clones which code for large
RT   proteins.";
RL   DNA Res. 8:319-327(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-511.
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 210-670.
RC   TISSUE=Melanoma;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB85537.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB075831; BAB85537.1; ALT_INIT; mRNA.
DR   EMBL; AK122649; BAG53641.1; -; mRNA.
DR   EMBL; CH471126; EAW57113.1; -; Genomic_DNA.
DR   EMBL; BC013013; AAH13013.1; -; mRNA.
DR   EMBL; AL833399; CAH10586.1; -; mRNA.
DR   CCDS; CCDS12598.1; -.
DR   RefSeq; NP_001300962.1; NM_001314033.2.
DR   RefSeq; NP_597701.1; NM_133444.2.
DR   UniGene; Hs.137282; -.
DR   ProteinModelPortal; Q8TF50; -.
DR   SMR; Q8TF50; -.
DR   BioGrid; 125475; 18.
DR   IntAct; Q8TF50; 70.
DR   STRING; 9606.ENSP00000301215; -.
DR   iPTMnet; Q8TF50; -.
DR   PhosphoSitePlus; Q8TF50; -.
DR   BioMuta; ZNF526; -.
DR   DMDM; 158706495; -.
DR   MaxQB; Q8TF50; -.
DR   PaxDb; Q8TF50; -.
DR   PeptideAtlas; Q8TF50; -.
DR   PRIDE; Q8TF50; -.
DR   Ensembl; ENST00000301215; ENSP00000301215; ENSG00000167625.
DR   GeneID; 116115; -.
DR   KEGG; hsa:116115; -.
DR   UCSC; uc002osz.2; human.
DR   CTD; 116115; -.
DR   DisGeNET; 116115; -.
DR   GeneCards; ZNF526; -.
DR   HGNC; HGNC:29415; ZNF526.
DR   HPA; HPA023070; -.
DR   HPA; HPA056609; -.
DR   MIM; 614387; gene.
DR   neXtProt; NX_Q8TF50; -.
DR   OpenTargets; ENSG00000167625; -.
DR   PharmGKB; PA134967668; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00670000098063; -.
DR   HOGENOM; HOG000065747; -.
DR   HOVERGEN; HBG103121; -.
DR   InParanoid; Q8TF50; -.
DR   OMA; TIMCTEL; -.
DR   OrthoDB; EOG091G05J3; -.
DR   PhylomeDB; Q8TF50; -.
DR   TreeFam; TF350791; -.
DR   GenomeRNAi; 116115; -.
DR   PRO; PR:Q8TF50; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000167625; -.
DR   CleanEx; HS_ZNF526; -.
DR   ExpressionAtlas; Q8TF50; baseline and differential.
DR   Genevisible; Q8TF50; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    670       Zinc finger protein 526.
FT                                /FTId=PRO_0000306875.
FT   ZN_FING      57     79       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     108    130       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     140    163       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     197    219       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     305    327       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     332    354       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     360    382       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     388    409       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     442    465       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     472    494       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     500    522       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     528    550       C2H2-type 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     573    595       C2H2-type 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    191    256       Glu-rich.
FT   COMPBIAS    416    445       Pro-rich.
FT   COMPBIAS    605    619       Pro-rich.
FT   VARIANT      94     94       V -> A (in dbSNP:rs3810151).
FT                                /FTId=VAR_035331.
FT   VARIANT     511    511       S -> F (in dbSNP:rs17850994).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_035332.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       500    527       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       573    600       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       307    327       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       472    499       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       197    219       ismart:ZnF_C2H2 [T]
FT   MYHIT       472    494       ismart:ZnF_C2H2 [T]
FT   MYHIT       362    382       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       528    550       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       332    354       ismart:ZnF_C2H2 [T]
FT   MYHIT        57     79       ismart:ZnF_C2H2 [T]
FT   MYHIT       108    135       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       334    354       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       332    359       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       273    296       ismart:ZnF_C2H2 [T]
FT   MYHIT       305    332       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       199    219       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       442    470       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       142    163       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT        57     79       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       528    550       ismart:ZnF_C2H2 [T]
FT   MYHIT       388    409       ismart:ZnF_C2H2 [T]
FT   MYHIT       502    522       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       573    595       ismart:ZnF_C2H2 [T]
FT   MYHIT       140    163       ismart:ZnF_C2H2 [T]
FT   MYHIT       108    130       ismart:ZnF_C2H2 [T]
FT   MYHIT       530    550       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       305    327       ismart:ZnF_C2H2 [T]
FT   MYHIT       500    522       ismart:ZnF_C2H2 [T]
FT   MYHIT        59     79       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       444    465       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       575    595       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       388    414       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       360    382       ismart:ZnF_C2H2 [T]
FT   MYHIT       442    465       ismart:ZnF_C2H2 [T]
FT   MYHIT       360    387       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       474    494       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       110    130       ipat:ZINC_FINGER_C2H2_1 [T]
SQ   SEQUENCE   670 AA;  73622 MW;  83C09EB3961765E8 CRC64;
     MAEVVAEVAE MPTQMSPGAV EMSTPMSAEM MEMSTEVTEM TPGEALASSL FFQHHQFMCS
     ECGSLYNTLE EVLSHQEQHM LAVSEEEALT TQNVGLEPEL VPGAEGPFQC GECSQLILSP
     GELLAHQDAH LRESANQIQY QCWDCQELFP SPELWVAHRK AQHLSATVAE PPVPPPLPPP
     TPLPPPSPPS EVKMEPYECP ECSTLCATPE EFLEHQGTHF DSLEKEERNG LEEEEEDDEE
     DEEDDEEMED EEAMAEVGDD AVGGDESTAG WAQGCGDCPQ HQPSAGARRQ HRRTAHSPAS
     ATHPFHCSQC QRSFSSANRL QAHGRAHVGG THECTTCSKV FKKAASLEQH LRLHRGEARY
     LCVDCGRGFG TELTLVAHRR AHTANPLHRC RCGKTFSNMT KFLYHRRTHA GKSGAPPTGA
     TAPPAPAEPT PPPPPPAPPA QLPCPQCSKS FASASRLSRH RRAVHGPPER RHRCGVCGKG
     FKKLIHVRNH LRTHTGERPF QCHSCGKTFA SLANLSRHQL THTGARPYQC LDCGKRFTQS
     SNLQQHRRLH LRPVAFARAP RLPITGLYNK SPYYCGTCGR WFRAMAGLRL HQRVHARART
     LTLQPPRSPS PAPPPPPEPQ QTIMCTELGE TIAIIETSQP LALEDTLQLC QAALGASEAG
     GLLQLDTAFV
//