ID ZN511_MOUSE Reviewed; 227 AA.
AC Q6P0X2;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 10-MAY-2017, entry version 84.
DE RecName: Full=Zinc finger protein 511;
GN Name=Znf511; Synonyms=Zfp511;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-238 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.O113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
RA Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
RA Vemulapalli V., Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P0X2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P0X2-2; Sequence=VSP_035623;
CC Note=Contains a omega-N-methylarginine at position 238.
CC {ECO:0000244|PubMed:24129315};
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC109205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC065404; AAH65404.1; -; mRNA.
DR CCDS; CCDS52431.1; -. [Q6P0X2-2]
DR RefSeq; NP_081477.1; NM_027201.1. [Q6P0X2-2]
DR UniGene; Mm.200818; -.
DR ProteinModelPortal; Q6P0X2; -.
DR STRING; 10090.ENSMUSP00000129154; -.
DR PhosphoSitePlus; Q6P0X2; -.
DR EPD; Q6P0X2; -.
DR PaxDb; Q6P0X2; -.
DR PeptideAtlas; Q6P0X2; -.
DR PRIDE; Q6P0X2; -.
DR Ensembl; ENSMUST00000168194; ENSMUSP00000129154; ENSMUSG00000025470. [Q6P0X2-2]
DR GeneID; 69752; -.
DR KEGG; mmu:69752; -.
DR UCSC; uc012fwe.1; mouse. [Q6P0X2-2]
DR CTD; 69752; -.
DR MGI; MGI:1917002; Zfp511.
DR eggNOG; KOG4173; Eukaryota.
DR eggNOG; ENOG4111TX5; LUCA.
DR GeneTree; ENSGT00390000011381; -.
DR HOVERGEN; HBG094183; -.
DR InParanoid; Q6P0X2; -.
DR OMA; CFGQGAA; -.
DR OrthoDB; EOG091G0JFZ; -.
DR PhylomeDB; Q6P0X2; -.
DR TreeFam; TF323277; -.
DR PRO; PR:Q6P0X2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000025470; -.
DR ExpressionAtlas; Q6P0X2; baseline and differential.
DR Genevisible; Q6P0X2; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Methylation; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 227 Zinc finger protein 511.
FT /FTId=PRO_0000353091.
FT ZN_FING 80 105 C2H2-type 1.
FT ZN_FING 107 130 C2H2-type 2.
FT ZN_FING 144 169 C2H2-type 3.
FT VAR_SEQ 226 227 SV -> IPSTVCFGQGAARGFKSTKKKNKHH (in
FT isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_035623.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 80 105 ismart:ZnF_C2H2 [T]
FT MYHIT 109 130 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 146 169 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 82 105 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 144 169 ismart:ZnF_C2H2 [T]
FT MYHIT 107 130 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 227 AA; 25761 MW; 7FCA52DF931D5DA7 CRC64;
MLLPPALYSR LAGEPGAAEP LPVERNPAAG EAPFRFAPRA VRFPRDHEFF EDGDVQRHLY
LQDMLTQVSE TPEKSMVPEF TCQVAGCCQV FAAIEDYQHH YHMMHGNTCS FCNRAFPSGH
LLDVHILEWH DSLFQILAQR QDMYQCLVES CPEKFKTSQD RKDHMVRLHL YPADFRFDKP
KTNRGPAMPA AADAATRAPT DDSDAMEICS EPAAPPPCRR TYSHRSV
//
|
