Entry euk:ZN497_HUMAN

ID   ZN497_HUMAN             Reviewed;         498 AA.
AC   Q6ZNH5; Q05AG8; Q0VF48; Q6ZTD2; Q9UIA8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   10-MAY-2017, entry version 118.
DE   RecName: Full=Zinc finger protein 497;
GN   Name=ZNF497;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-174.
RC   TISSUE=Cerebellum, and Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-174.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 176-329.
RA   Ma X., Huang B.;
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q63HR2:TNS2; NbExp=4; IntAct=EBI-10486136, EBI-949753;
CC       Q3KQV3:ZNF792; NbExp=4; IntAct=EBI-10486136, EBI-10240849;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AK126727; BAC86660.1; -; mRNA.
DR   EMBL; AK131209; BAD18400.1; -; mRNA.
DR   EMBL; CH471135; EAW72578.1; -; Genomic_DNA.
DR   EMBL; BC118983; AAI18984.1; -; mRNA.
DR   EMBL; BC125273; AAI25274.1; -; mRNA.
DR   EMBL; AF064790; AAF16412.1; -; Genomic_DNA.
DR   CCDS; CCDS12977.1; -.
DR   RefSeq; NP_001193938.1; NM_001207009.1.
DR   RefSeq; NP_940860.2; NM_198458.2.
DR   UniGene; Hs.447840; -.
DR   ProteinModelPortal; Q6ZNH5; -.
DR   SMR; Q6ZNH5; -.
DR   BioGrid; 127835; 2.
DR   IntAct; Q6ZNH5; 34.
DR   STRING; 9606.ENSP00000311183; -.
DR   iPTMnet; Q6ZNH5; -.
DR   PhosphoSitePlus; Q6ZNH5; -.
DR   BioMuta; ZNF497; -.
DR   DMDM; 229462815; -.
DR   PaxDb; Q6ZNH5; -.
DR   PeptideAtlas; Q6ZNH5; -.
DR   PRIDE; Q6ZNH5; -.
DR   Ensembl; ENST00000311044; ENSP00000311183; ENSG00000174586.
DR   Ensembl; ENST00000425453; ENSP00000402815; ENSG00000174586.
DR   GeneID; 162968; -.
DR   KEGG; hsa:162968; -.
DR   UCSC; uc002qsh.3; human.
DR   CTD; 162968; -.
DR   GeneCards; ZNF497; -.
DR   HGNC; HGNC:23714; ZNF497.
DR   HPA; HPA047872; -.
DR   neXtProt; NX_Q6ZNH5; -.
DR   OpenTargets; ENSG00000174586; -.
DR   PharmGKB; PA134994387; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00870000136571; -.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q6ZNH5; -.
DR   OMA; AFSWNSN; -.
DR   OrthoDB; EOG091G02KC; -.
DR   PhylomeDB; Q6ZNH5; -.
DR   TreeFam; TF337005; -.
DR   GenomeRNAi; 162968; -.
DR   PRO; PR:Q6ZNH5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000174586; -.
DR   CleanEx; HS_ZNF497; -.
DR   ExpressionAtlas; Q6ZNH5; baseline and differential.
DR   Genevisible; Q6ZNH5; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF57667; SSF57667; 8.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    498       Zinc finger protein 497.
FT                                /FTId=PRO_0000047618.
FT   ZN_FING     106    128       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     134    156       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     162    184       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     190    212       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     218    240       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     246    268       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     274    296       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     302    324       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     330    352       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     358    380       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     386    408       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     414    436       C2H2-type 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     442    464       C2H2-type 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     470    492       C2H2-type 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VARIANT     174    174       H -> Q (in dbSNP:rs12609654).
FT                                {ECO:0000269|PubMed:14702039,
FT                                ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_055270.
FT   CONFLICT    212    214       HTG -> RA (in Ref. 4; AAF16412).
FT                                {ECO:0000305}.
FT   CONFLICT    241    241       T -> A (in Ref. 4; AAF16412).
FT                                {ECO:0000305}.
FT   CONFLICT    320    320       H -> Y (in Ref. 4; AAF16412).
FT                                {ECO:0000305}.
FT   CONFLICT    367    367       F -> S (in Ref. 1; BAC86660).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       190    212       ismart:ZnF_C2H2 [T]
FT   MYHIT       388    408       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       414    441       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       304    324       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       248    268       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       246    273       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       274    301       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       358    385       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       414    436       ismart:ZnF_C2H2 [T]
FT   MYHIT       164    184       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       332    352       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       444    464       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       136    156       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       330    357       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       416    436       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       134    156       ismart:ZnF_C2H2 [T]
FT   MYHIT       106    133       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       442    469       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       386    408       ismart:ZnF_C2H2 [T]
FT   MYHIT       330    352       ismart:ZnF_C2H2 [T]
FT   MYHIT       470    492       ismart:ZnF_C2H2 [T]
FT   MYHIT       218    245       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       162    184       ismart:ZnF_C2H2 [T]
FT   MYHIT       192    212       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       274    296       ismart:ZnF_C2H2 [T]
FT   MYHIT       470    497       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       218    240       ismart:ZnF_C2H2 [T]
FT   MYHIT       246    268       ismart:ZnF_C2H2 [T]
FT   MYHIT       134    161       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       360    380       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       302    329       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       472    492       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       386    413       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       302    324       ismart:ZnF_C2H2 [T]
FT   MYHIT       106    128       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       220    240       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       190    217       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       106    128       ismart:ZnF_C2H2 [T]
FT   MYHIT       276    296       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       442    464       ismart:ZnF_C2H2 [T]
FT   MYHIT       162    189       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       358    380       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   498 AA;  54721 MW;  AAC4DD81A06CECFA CRC64;
     MESPRGWTLQ VAPEEGQVLC NVKTATRGLS EGAVSGGWGA WENSTEVPRE AGDGQRQQAT
     LGAADEQGGP GRELGPADGG RDGAGPRSEP ADRALRPSPL PEEPGCRCGE CGKAFSQGSY
     LLQHRRVHTG EKPYTCPECG KAFAWSSNLS QHQRIHSGEK PYACRECGKA FRAHSQLIHH
     QETHSGLKPF RCPDCGKSFG RSTTLVQHRR THTGEKPYEC PECGKAFSWN SNFLEHRRVH
     TGARPHACRD CGKAFSQSSN LAEHLKIHAG ARPHACPDCG KAFVRVAGLR QHRRTHSSEK
     PFPCAECGKA FRESSQLLQH QRTHTGERPF ECAECGQAFV MGSYLAEHRR VHTGEKPHAC
     AQCGKAFSQR SNLLSHRRTH SGAKPFACAD CGKAFRGSSG LAHHRLSHTG ERPFACAECG
     KAFRGSSELR QHQRLHSGER PFVCAHCSKA FVRKSELLSH RRTHTGERPY ACGECGKPFS
     HRCNLNEHQK RHGGRAAP
//