ID ZN497_HUMAN Reviewed; 498 AA.
AC Q6ZNH5; Q05AG8; Q0VF48; Q6ZTD2; Q9UIA8;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 10-MAY-2017, entry version 118.
DE RecName: Full=Zinc finger protein 497;
GN Name=ZNF497;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-174.
RC TISSUE=Cerebellum, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-174.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 176-329.
RA Ma X., Huang B.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q63HR2:TNS2; NbExp=4; IntAct=EBI-10486136, EBI-949753;
CC Q3KQV3:ZNF792; NbExp=4; IntAct=EBI-10486136, EBI-10240849;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK126727; BAC86660.1; -; mRNA.
DR EMBL; AK131209; BAD18400.1; -; mRNA.
DR EMBL; CH471135; EAW72578.1; -; Genomic_DNA.
DR EMBL; BC118983; AAI18984.1; -; mRNA.
DR EMBL; BC125273; AAI25274.1; -; mRNA.
DR EMBL; AF064790; AAF16412.1; -; Genomic_DNA.
DR CCDS; CCDS12977.1; -.
DR RefSeq; NP_001193938.1; NM_001207009.1.
DR RefSeq; NP_940860.2; NM_198458.2.
DR UniGene; Hs.447840; -.
DR ProteinModelPortal; Q6ZNH5; -.
DR SMR; Q6ZNH5; -.
DR BioGrid; 127835; 2.
DR IntAct; Q6ZNH5; 34.
DR STRING; 9606.ENSP00000311183; -.
DR iPTMnet; Q6ZNH5; -.
DR PhosphoSitePlus; Q6ZNH5; -.
DR BioMuta; ZNF497; -.
DR DMDM; 229462815; -.
DR PaxDb; Q6ZNH5; -.
DR PeptideAtlas; Q6ZNH5; -.
DR PRIDE; Q6ZNH5; -.
DR Ensembl; ENST00000311044; ENSP00000311183; ENSG00000174586.
DR Ensembl; ENST00000425453; ENSP00000402815; ENSG00000174586.
DR GeneID; 162968; -.
DR KEGG; hsa:162968; -.
DR UCSC; uc002qsh.3; human.
DR CTD; 162968; -.
DR GeneCards; ZNF497; -.
DR HGNC; HGNC:23714; ZNF497.
DR HPA; HPA047872; -.
DR neXtProt; NX_Q6ZNH5; -.
DR OpenTargets; ENSG00000174586; -.
DR PharmGKB; PA134994387; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00870000136571; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q6ZNH5; -.
DR OMA; AFSWNSN; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q6ZNH5; -.
DR TreeFam; TF337005; -.
DR GenomeRNAi; 162968; -.
DR PRO; PR:Q6ZNH5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000174586; -.
DR CleanEx; HS_ZNF497; -.
DR ExpressionAtlas; Q6ZNH5; baseline and differential.
DR Genevisible; Q6ZNH5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 498 Zinc finger protein 497.
FT /FTId=PRO_0000047618.
FT ZN_FING 106 128 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 134 156 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 162 184 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 190 212 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 218 240 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 246 268 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 274 296 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 302 324 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 330 352 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 358 380 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 386 408 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 414 436 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 442 464 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 470 492 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VARIANT 174 174 H -> Q (in dbSNP:rs12609654).
FT {ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_055270.
FT CONFLICT 212 214 HTG -> RA (in Ref. 4; AAF16412).
FT {ECO:0000305}.
FT CONFLICT 241 241 T -> A (in Ref. 4; AAF16412).
FT {ECO:0000305}.
FT CONFLICT 320 320 H -> Y (in Ref. 4; AAF16412).
FT {ECO:0000305}.
FT CONFLICT 367 367 F -> S (in Ref. 1; BAC86660).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 162 189 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 332 352 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 106 128 ismart:ZnF_C2H2 [T]
FT MYHIT 442 469 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 218 245 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 444 464 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 134 156 ismart:ZnF_C2H2 [T]
FT MYHIT 190 217 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 302 324 ismart:ZnF_C2H2 [T]
FT MYHIT 358 380 ismart:ZnF_C2H2 [T]
FT MYHIT 246 273 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 414 436 ismart:ZnF_C2H2 [T]
FT MYHIT 218 240 ismart:ZnF_C2H2 [T]
FT MYHIT 304 324 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 220 240 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 246 268 ismart:ZnF_C2H2 [T]
FT MYHIT 470 497 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 162 184 ismart:ZnF_C2H2 [T]
FT MYHIT 360 380 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 386 408 ismart:ZnF_C2H2 [T]
FT MYHIT 330 352 ismart:ZnF_C2H2 [T]
FT MYHIT 134 161 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 330 357 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 416 436 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 302 329 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 358 385 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 248 268 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 274 301 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 274 296 ismart:ZnF_C2H2 [T]
FT MYHIT 164 184 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 106 128 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 442 464 ismart:ZnF_C2H2 [T]
FT MYHIT 192 212 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 472 492 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 276 296 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 386 413 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 414 441 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 136 156 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 470 492 ismart:ZnF_C2H2 [T]
FT MYHIT 388 408 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 190 212 ismart:ZnF_C2H2 [T]
FT MYHIT 106 133 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 498 AA; 54721 MW; AAC4DD81A06CECFA CRC64;
MESPRGWTLQ VAPEEGQVLC NVKTATRGLS EGAVSGGWGA WENSTEVPRE AGDGQRQQAT
LGAADEQGGP GRELGPADGG RDGAGPRSEP ADRALRPSPL PEEPGCRCGE CGKAFSQGSY
LLQHRRVHTG EKPYTCPECG KAFAWSSNLS QHQRIHSGEK PYACRECGKA FRAHSQLIHH
QETHSGLKPF RCPDCGKSFG RSTTLVQHRR THTGEKPYEC PECGKAFSWN SNFLEHRRVH
TGARPHACRD CGKAFSQSSN LAEHLKIHAG ARPHACPDCG KAFVRVAGLR QHRRTHSSEK
PFPCAECGKA FRESSQLLQH QRTHTGERPF ECAECGQAFV MGSYLAEHRR VHTGEKPHAC
AQCGKAFSQR SNLLSHRRTH SGAKPFACAD CGKAFRGSSG LAHHRLSHTG ERPFACAECG
KAFRGSSELR QHQRLHSGER PFVCAHCSKA FVRKSELLSH RRTHTGERPY ACGECGKPFS
HRCNLNEHQK RHGGRAAP
//
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