ID ZN449_HUMAN Reviewed; 518 AA.
AC Q6P9G9; Q5JRZ7; Q5JRZ8; Q6NZX2; Q8N3Q1; Q8TED7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 3.
DT 10-MAY-2017, entry version 125.
DE RecName: Full=Zinc finger protein 449;
DE AltName: Full=Zinc finger and SCAN domain-containing protein 19;
GN Name=ZNF449; Synonyms=ZSCAN19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Luo K.T., Yu L.;
RT "Cloning and characterization of a human novel znf gene.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Adipose tissue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Adipose tissue;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P57086:SCAND1; NbExp=5; IntAct=EBI-10215956, EBI-745846;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC ProRule:PRU00187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6P9G9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P9G9-2; Sequence=VSP_011949, VSP_011950;
CC Note=No experimental confirmation available.;
CC Name=3;
CC IsoId=Q6P9G9-3; Sequence=VSP_011951, VSP_011952;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -----------------------------------------------------------------------
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DR EMBL; AY280801; AAQ16305.1; -; mRNA.
DR EMBL; AK074194; BAB85013.1; -; mRNA.
DR EMBL; AL833407; CAD38639.1; -; mRNA.
DR EMBL; AL450472; CAI39872.1; -; Genomic_DNA.
DR EMBL; AL450472; CAI39873.1; -; Genomic_DNA.
DR EMBL; BC060768; AAH60768.1; -; mRNA.
DR EMBL; BC065938; AAH65938.1; -; mRNA.
DR CCDS; CCDS14649.1; -. [Q6P9G9-1]
DR RefSeq; NP_689908.3; NM_152695.5. [Q6P9G9-1]
DR RefSeq; XP_011529614.1; XM_011531312.2. [Q6P9G9-1]
DR UniGene; Hs.28780; -.
DR ProteinModelPortal; Q6P9G9; -.
DR SMR; Q6P9G9; -.
DR BioGrid; 128476; 3.
DR IntAct; Q6P9G9; 3.
DR STRING; 9606.ENSP00000339585; -.
DR iPTMnet; Q6P9G9; -.
DR PhosphoSitePlus; Q6P9G9; -.
DR BioMuta; ZNF449; -.
DR DMDM; 92090580; -.
DR PaxDb; Q6P9G9; -.
DR PeptideAtlas; Q6P9G9; -.
DR PRIDE; Q6P9G9; -.
DR DNASU; 203523; -.
DR Ensembl; ENST00000339249; ENSP00000339585; ENSG00000173275. [Q6P9G9-1]
DR Ensembl; ENST00000370761; ENSP00000359797; ENSG00000173275. [Q6P9G9-2]
DR GeneID; 203523; -.
DR KEGG; hsa:203523; -.
DR UCSC; uc004eyr.5; human. [Q6P9G9-1]
DR CTD; 203523; -.
DR GeneCards; ZNF449; -.
DR HGNC; HGNC:21039; ZNF449.
DR HPA; HPA018079; -.
DR MIM; 300627; gene.
DR neXtProt; NX_Q6P9G9; -.
DR OpenTargets; ENSG00000173275; -.
DR PharmGKB; PA134920699; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00730000110971; -.
DR HOGENOM; HOG000234619; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q6P9G9; -.
DR KO; K09230; -.
DR OMA; PVAEAWI; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q6P9G9; -.
DR TreeFam; TF336949; -.
DR GenomeRNAi; 203523; -.
DR PRO; PR:Q6P9G9; -.
DR Proteomes; UP000005640; Chromosome X.
DR Bgee; ENSG00000173275; -.
DR CleanEx; HS_ZNF449; -.
DR Genevisible; Q6P9G9; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF47353; SSF47353; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 518 Zinc finger protein 449.
FT /FTId=PRO_0000047597.
FT DOMAIN 30 112 SCAN box. {ECO:0000255|PROSITE-
FT ProRule:PRU00187}.
FT ZN_FING 323 345 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 351 373 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 379 401 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 407 429 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 435 457 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 463 485 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 491 513 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 119 127 VDMHDMLLE -> TFAAEYSHY (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_011951.
FT VAR_SEQ 120 164 DMHDMLLEELAPVGTAHIPPTMHLESPALQVMGPAQEAPVA
FT EAWI -> RKECGIFVIGPKEVAEAAGTRPHICLYVIPQPQ
FT DFSRVLFLFLFC (in isoform 2).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_011949.
FT VAR_SEQ 128 518 Missing (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_011952.
FT VAR_SEQ 165 518 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_011950.
FT CONFLICT 124 124 M -> I (in Ref. 1; AAQ16305 and 3;
FT CAD38639). {ECO:0000305}.
FT CONFLICT 187 187 G -> V (in Ref. 1; AAQ16305 and 3;
FT CAD38639). {ECO:0000305}.
FT CONFLICT 293 293 P -> L (in Ref. 1; AAQ16305 and 3;
FT CAD38639). {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 407 434 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 323 345 ismart:ZnF_C2H2 [T]
FT MYHIT 491 513 ismart:ZnF_C2H2 [T]
FT MYHIT 463 485 ismart:ZnF_C2H2 [T]
FT MYHIT 437 457 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 407 429 ismart:ZnF_C2H2 [T]
FT MYHIT 27 113 ipfam:SCAN [T]
FT MYHIT 493 513 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 379 406 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 409 429 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 435 457 ismart:ZnF_C2H2 [T]
FT MYHIT 465 485 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 353 373 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 351 378 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 351 373 ismart:ZnF_C2H2 [T]
FT MYHIT 435 462 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 323 350 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 379 401 ismart:ZnF_C2H2 [T]
FT MYHIT 325 345 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 491 513 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 26 134 ismart:SCAN [T]
FT MYHIT 381 401 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 30 112 iprf:SCAN_BOX [T]
FT MYHIT 463 490 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 518 AA; 59932 MW; E6CDA288C489BAB8 CRC64;
MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK LWELCCQWLK
PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER VVSLIEDLQR ELEIPEQQVD
MHDMLLEELA PVGTAHIPPT MHLESPALQV MGPAQEAPVA EAWIPQAGPP ELNYGATGEC
QNFLDPGYPL PKLDMNFSLE NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK
KMETMYPFIV TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE
NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP HKCPECGKRF
LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT HSEEETYKCL ECGKSFCHGS
SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI
HLRIHTGEKP YKCTHCSKSF RQRAGLIMHQ VTHFRGLI
//
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