Entry euk:ZN396_HUMAN

ID   ZN396_HUMAN             Reviewed;         335 AA.
AC   Q96N95; A1L3V0; Q8NF98; Q8TD80;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2003, sequence version 2.
DT   10-MAY-2017, entry version 149.
DE   RecName: Full=Zinc finger protein 396;
DE   AltName: Full=Zinc finger and SCAN domain-containing protein 14;
GN   Name=ZNF396; Synonyms=ZSCAN14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBUNIT,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Hepatoma;
RX   PubMed=12801647; DOI=10.1016/S0378-1119(03)00551-1;
RA   Wu Y., Yu L., Bi G., Luo K., Zhou G., Zhao S.;
RT   "Identification and characterization of two novel human SCAN domain-
RT   containing zinc finger genes ZNF396 and ZNF397.";
RL   Gene 310:193-201(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Isoform 1 and isoform 2 act as DNA-dependent
CC       transcriptional repressors. {ECO:0000269|PubMed:12801647}.
CC   -!- SUBUNIT: Isoforms 1 and 2 can both homo- and hetero-associate.
CC       {ECO:0000269|PubMed:12801647}.
CC   -!- SUBCELLULAR LOCATION: Isoform 1: Nucleus.
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=ZNF396-fu;
CC         IsoId=Q96N95-1; Sequence=Displayed;
CC       Name=2; Synonyms=Truncated, ZNF396-nf;
CC         IsoId=Q96N95-2; Sequence=VSP_008768, VSP_006923;
CC       Name=3;
CC         IsoId=Q96N95-3; Sequence=VSP_020993;
CC         Note=No experimental confirmation available.;
CC   -!- TISSUE SPECIFICITY: Expressed strongly in liver, moderately in
CC       skeletal muscle and weakly in kidney, pancreas, spleen and
CC       prostate. {ECO:0000269|PubMed:12801647}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AF492004; AAM09559.3; -; mRNA.
DR   EMBL; AF533251; AAM95992.1; -; mRNA.
DR   EMBL; AK055775; BAB71010.1; -; mRNA.
DR   EMBL; CH471088; EAX01352.1; -; Genomic_DNA.
DR   EMBL; BC130288; AAI30289.1; -; mRNA.
DR   EMBL; BC136314; AAI36315.1; -; mRNA.
DR   CCDS; CCDS11913.1; -. [Q96N95-3]
DR   CCDS; CCDS82246.1; -. [Q96N95-2]
DR   CCDS; CCDS82247.1; -. [Q96N95-1]
DR   RefSeq; NP_001309215.1; NM_001322286.1. [Q96N95-1]
DR   RefSeq; NP_001309219.1; NM_001322290.1. [Q96N95-1]
DR   RefSeq; NP_001309220.1; NM_001322291.1. [Q96N95-2]
DR   RefSeq; NP_665699.1; NM_145756.2. [Q96N95-3]
DR   RefSeq; XP_006722495.1; XM_006722432.3. [Q96N95-1]
DR   RefSeq; XP_016881176.1; XM_017025687.1. [Q96N95-1]
DR   RefSeq; XP_016881177.1; XM_017025688.1. [Q96N95-1]
DR   UniGene; Hs.351005; -.
DR   ProteinModelPortal; Q96N95; -.
DR   SMR; Q96N95; -.
DR   BioGrid; 128934; 14.
DR   IntAct; Q96N95; 4.
DR   STRING; 9606.ENSP00000302310; -.
DR   iPTMnet; Q96N95; -.
DR   PhosphoSitePlus; Q96N95; -.
DR   BioMuta; ZNF396; -.
DR   DMDM; 38258950; -.
DR   MaxQB; Q96N95; -.
DR   PaxDb; Q96N95; -.
DR   PeptideAtlas; Q96N95; -.
DR   PRIDE; Q96N95; -.
DR   TopDownProteomics; Q96N95-3; -. [Q96N95-3]
DR   DNASU; 252884; -.
DR   Ensembl; ENST00000306346; ENSP00000302310; ENSG00000186496. [Q96N95-3]
DR   Ensembl; ENST00000586687; ENSP00000467275; ENSG00000186496. [Q96N95-2]
DR   Ensembl; ENST00000589332; ENSP00000466500; ENSG00000186496. [Q96N95-1]
DR   GeneID; 252884; -.
DR   KEGG; hsa:252884; -.
DR   UCSC; uc010xcf.1; human. [Q96N95-1]
DR   CTD; 252884; -.
DR   GeneCards; ZNF396; -.
DR   HGNC; HGNC:18824; ZNF396.
DR   HPA; HPA006686; -.
DR   MIM; 609600; gene.
DR   neXtProt; NX_Q96N95; -.
DR   OpenTargets; ENSG00000186496; -.
DR   PharmGKB; PA38697; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00760000118881; -.
DR   HOGENOM; HOG000234619; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q96N95; -.
DR   KO; K09230; -.
DR   OMA; YACDECA; -.
DR   OrthoDB; EOG091G09O3; -.
DR   PhylomeDB; Q96N95; -.
DR   TreeFam; TF338304; -.
DR   GenomeRNAi; 252884; -.
DR   PRO; PR:Q96N95; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000186496; -.
DR   CleanEx; HS_ZNF396; -.
DR   ExpressionAtlas; Q96N95; baseline and differential.
DR   Genevisible; Q96N95; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF02023; SCAN; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF47353; SSF47353; 1.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Cytoplasm; DNA-binding;
KW   Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    335       Zinc finger protein 396.
FT                                /FTId=PRO_0000047563.
FT   DOMAIN       52    134       SCAN box. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00187}.
FT   ZN_FING     251    273       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     279    301       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     307    329       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VAR_SEQ     188    210       DEDIKTTNVKSASRQKTSLGIEL -> GEGAGFSSCWKVWG
FT                                PSAHHTHLS (in isoform 2).
FT                                {ECO:0000303|PubMed:12801647}.
FT                                /FTId=VSP_008768.
FT   VAR_SEQ     211    335       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:12801647}.
FT                                /FTId=VSP_006923.
FT   VAR_SEQ     303    335       GEKPYKCHDCGKAFSQSSNLFRHRKRHIRKKVP -> DSKY
FT                                EHAIAEAQKNMYFKTRLKCPRSLSGGR (in isoform
FT                                3). {ECO:0000303|PubMed:14702039,
FT                                ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_020993.
FT   VARIANT     211    211       H -> L (in dbSNP:rs9963473).
FT                                /FTId=VAR_057418.
FT   CONFLICT    125    125       T -> A (in Ref. 1; AAM09559).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       307    334       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       281    301       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       307    329       ismart:ZnF_C2H2 [T]
FT   MYHIT        48    158       ismart:SCAN [T]
FT   MYHIT       279    301       ismart:ZnF_C2H2 [T]
FT   MYHIT        48    135       ipfam:SCAN [T]
FT   MYHIT       251    278       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       309    329       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       279    306       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       253    273       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       251    273       ismart:ZnF_C2H2 [T]
FT   MYHIT        52    134       iprf:SCAN_BOX [T]
SQ   SEQUENCE   335 AA;  38612 MW;  2EC72390016E3E4F CRC64;
     MSAKLGKSSS LLTQTSEECN GILTEKMEEE EQTCDPDSSL HWSSSYSPET FRQQFRQFGY
     QDSPGPHEAL SRLWELCHLW LRPEVHTKEQ ILELLVLEQF LAILPKELQA WVQKHHPENG
     EETVTMLEDV ERELDGPKQI FFGRRKDMIA EKLAPSEITE ELPSSQLMPV KKQLQGASWE
     LQSLRPHDED IKTTNVKSAS RQKTSLGIEL HCNVSNILHM NGSQSSTYRG TYEQDGRFEK
     RQGNPSWKKQ QKCDECGKIF SQSSALILHQ RIHSGKKPYA CDECAKAFSR SAILIQHRRT
     HTGEKPYKCH DCGKAFSQSS NLFRHRKRHI RKKVP
//