ID ZN396_HUMAN Reviewed; 335 AA.
AC Q96N95; A1L3V0; Q8NF98; Q8TD80;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2003, sequence version 2.
DT 10-MAY-2017, entry version 149.
DE RecName: Full=Zinc finger protein 396;
DE AltName: Full=Zinc finger and SCAN domain-containing protein 14;
GN Name=ZNF396; Synonyms=ZSCAN14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBUNIT,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Hepatoma;
RX PubMed=12801647; DOI=10.1016/S0378-1119(03)00551-1;
RA Wu Y., Yu L., Bi G., Luo K., Zhou G., Zhao S.;
RT "Identification and characterization of two novel human SCAN domain-
RT containing zinc finger genes ZNF396 and ZNF397.";
RL Gene 310:193-201(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Isoform 1 and isoform 2 act as DNA-dependent
CC transcriptional repressors. {ECO:0000269|PubMed:12801647}.
CC -!- SUBUNIT: Isoforms 1 and 2 can both homo- and hetero-associate.
CC {ECO:0000269|PubMed:12801647}.
CC -!- SUBCELLULAR LOCATION: Isoform 1: Nucleus.
CC -!- SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=ZNF396-fu;
CC IsoId=Q96N95-1; Sequence=Displayed;
CC Name=2; Synonyms=Truncated, ZNF396-nf;
CC IsoId=Q96N95-2; Sequence=VSP_008768, VSP_006923;
CC Name=3;
CC IsoId=Q96N95-3; Sequence=VSP_020993;
CC Note=No experimental confirmation available.;
CC -!- TISSUE SPECIFICITY: Expressed strongly in liver, moderately in
CC skeletal muscle and weakly in kidney, pancreas, spleen and
CC prostate. {ECO:0000269|PubMed:12801647}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF492004; AAM09559.3; -; mRNA.
DR EMBL; AF533251; AAM95992.1; -; mRNA.
DR EMBL; AK055775; BAB71010.1; -; mRNA.
DR EMBL; CH471088; EAX01352.1; -; Genomic_DNA.
DR EMBL; BC130288; AAI30289.1; -; mRNA.
DR EMBL; BC136314; AAI36315.1; -; mRNA.
DR CCDS; CCDS11913.1; -. [Q96N95-3]
DR CCDS; CCDS82246.1; -. [Q96N95-2]
DR CCDS; CCDS82247.1; -. [Q96N95-1]
DR RefSeq; NP_001309215.1; NM_001322286.1. [Q96N95-1]
DR RefSeq; NP_001309219.1; NM_001322290.1. [Q96N95-1]
DR RefSeq; NP_001309220.1; NM_001322291.1. [Q96N95-2]
DR RefSeq; NP_665699.1; NM_145756.2. [Q96N95-3]
DR RefSeq; XP_006722495.1; XM_006722432.3. [Q96N95-1]
DR RefSeq; XP_016881176.1; XM_017025687.1. [Q96N95-1]
DR RefSeq; XP_016881177.1; XM_017025688.1. [Q96N95-1]
DR UniGene; Hs.351005; -.
DR ProteinModelPortal; Q96N95; -.
DR SMR; Q96N95; -.
DR BioGrid; 128934; 14.
DR IntAct; Q96N95; 4.
DR STRING; 9606.ENSP00000302310; -.
DR iPTMnet; Q96N95; -.
DR PhosphoSitePlus; Q96N95; -.
DR BioMuta; ZNF396; -.
DR DMDM; 38258950; -.
DR MaxQB; Q96N95; -.
DR PaxDb; Q96N95; -.
DR PeptideAtlas; Q96N95; -.
DR PRIDE; Q96N95; -.
DR TopDownProteomics; Q96N95-3; -. [Q96N95-3]
DR DNASU; 252884; -.
DR Ensembl; ENST00000306346; ENSP00000302310; ENSG00000186496. [Q96N95-3]
DR Ensembl; ENST00000586687; ENSP00000467275; ENSG00000186496. [Q96N95-2]
DR Ensembl; ENST00000589332; ENSP00000466500; ENSG00000186496. [Q96N95-1]
DR GeneID; 252884; -.
DR KEGG; hsa:252884; -.
DR UCSC; uc010xcf.1; human. [Q96N95-1]
DR CTD; 252884; -.
DR GeneCards; ZNF396; -.
DR HGNC; HGNC:18824; ZNF396.
DR HPA; HPA006686; -.
DR MIM; 609600; gene.
DR neXtProt; NX_Q96N95; -.
DR OpenTargets; ENSG00000186496; -.
DR PharmGKB; PA38697; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000118881; -.
DR HOGENOM; HOG000234619; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q96N95; -.
DR KO; K09230; -.
DR OMA; YACDECA; -.
DR OrthoDB; EOG091G09O3; -.
DR PhylomeDB; Q96N95; -.
DR TreeFam; TF338304; -.
DR GenomeRNAi; 252884; -.
DR PRO; PR:Q96N95; -.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000186496; -.
DR CleanEx; HS_ZNF396; -.
DR ExpressionAtlas; Q96N95; baseline and differential.
DR Genevisible; Q96N95; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF47353; SSF47353; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm; DNA-binding;
KW Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 335 Zinc finger protein 396.
FT /FTId=PRO_0000047563.
FT DOMAIN 52 134 SCAN box. {ECO:0000255|PROSITE-
FT ProRule:PRU00187}.
FT ZN_FING 251 273 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 279 301 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 307 329 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 188 210 DEDIKTTNVKSASRQKTSLGIEL -> GEGAGFSSCWKVWG
FT PSAHHTHLS (in isoform 2).
FT {ECO:0000303|PubMed:12801647}.
FT /FTId=VSP_008768.
FT VAR_SEQ 211 335 Missing (in isoform 2).
FT {ECO:0000303|PubMed:12801647}.
FT /FTId=VSP_006923.
FT VAR_SEQ 303 335 GEKPYKCHDCGKAFSQSSNLFRHRKRHIRKKVP -> DSKY
FT EHAIAEAQKNMYFKTRLKCPRSLSGGR (in isoform
FT 3). {ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_020993.
FT VARIANT 211 211 H -> L (in dbSNP:rs9963473).
FT /FTId=VAR_057418.
FT CONFLICT 125 125 T -> A (in Ref. 1; AAM09559).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 251 278 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 253 273 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 52 134 iprf:SCAN_BOX [T]
FT MYHIT 48 158 ismart:SCAN [T]
FT MYHIT 279 301 ismart:ZnF_C2H2 [T]
FT MYHIT 309 329 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 48 135 ipfam:SCAN [T]
FT MYHIT 279 306 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 251 273 ismart:ZnF_C2H2 [T]
FT MYHIT 307 329 ismart:ZnF_C2H2 [T]
FT MYHIT 307 334 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 281 301 ipat:ZINC_FINGER_C2H2_1 [T]
SQ SEQUENCE 335 AA; 38612 MW; 2EC72390016E3E4F CRC64;
MSAKLGKSSS LLTQTSEECN GILTEKMEEE EQTCDPDSSL HWSSSYSPET FRQQFRQFGY
QDSPGPHEAL SRLWELCHLW LRPEVHTKEQ ILELLVLEQF LAILPKELQA WVQKHHPENG
EETVTMLEDV ERELDGPKQI FFGRRKDMIA EKLAPSEITE ELPSSQLMPV KKQLQGASWE
LQSLRPHDED IKTTNVKSAS RQKTSLGIEL HCNVSNILHM NGSQSSTYRG TYEQDGRFEK
RQGNPSWKKQ QKCDECGKIF SQSSALILHQ RIHSGKKPYA CDECAKAFSR SAILIQHRRT
HTGEKPYKCH DCGKAFSQSS NLFRHRKRHI RKKVP
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