ID ZN333_HUMAN Reviewed; 665 AA.
AC Q96JL9; Q6P2E6; Q86WS6; Q8TDL0;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2003, sequence version 3.
DT 10-MAY-2017, entry version 137.
DE RecName: Full=Zinc finger protein 333;
GN Name=ZNF333; Synonyms=KIAA1806;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12151103; DOI=10.1016/S0167-4781(02)00397-4;
RA Tian Y., Breedveld G.J., Huang S., Oostra B.A., Heutink P., Lo W.H.Y.;
RT "Characterization of ZNF333, a novel double KRAB domain containing
RT zinc finger gene on human chromosome 19p13.1.";
RL Biochim. Biophys. Acta 1577:121-125(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Ovary, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-665 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 8:85-95(2001).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96JL9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96JL9-2; Sequence=VSP_055945, VSP_055946;
CC Name=3;
CC IsoId=Q96JL9-3; Sequence=VSP_055947, VSP_055948;
CC Note=No experimental confirmation available.;
CC -!- TISSUE SPECIFICITY: Highly expressed in heart.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF372702; AAM15528.1; -; mRNA.
DR EMBL; AK291471; BAF84160.1; -; mRNA.
DR EMBL; BC048107; AAH48107.1; -; mRNA.
DR EMBL; BC064571; AAH64571.1; -; mRNA.
DR EMBL; AB058709; BAB47435.1; -; mRNA.
DR CCDS; CCDS12316.1; -. [Q96JL9-1]
DR CCDS; CCDS74298.1; -. [Q96JL9-3]
DR RefSeq; NP_001287841.1; NM_001300912.1. [Q96JL9-3]
DR RefSeq; NP_115809.1; NM_032433.2. [Q96JL9-1]
DR RefSeq; XP_011526664.1; XM_011528362.2. [Q96JL9-1]
DR RefSeq; XP_016882856.1; XM_017027367.1. [Q96JL9-1]
DR UniGene; Hs.515215; -.
DR ProteinModelPortal; Q96JL9; -.
DR SMR; Q96JL9; -.
DR BioGrid; 124087; 6.
DR IntAct; Q96JL9; 2.
DR MINT; MINT-8417739; -.
DR STRING; 9606.ENSP00000292530; -.
DR iPTMnet; Q96JL9; -.
DR PhosphoSitePlus; Q96JL9; -.
DR BioMuta; ZNF333; -.
DR DMDM; 29840870; -.
DR EPD; Q96JL9; -.
DR PaxDb; Q96JL9; -.
DR PeptideAtlas; Q96JL9; -.
DR PRIDE; Q96JL9; -.
DR DNASU; 84449; -.
DR Ensembl; ENST00000292530; ENSP00000292530; ENSG00000160961. [Q96JL9-1]
DR Ensembl; ENST00000540689; ENSP00000438130; ENSG00000160961. [Q96JL9-3]
DR GeneID; 84449; -.
DR KEGG; hsa:84449; -.
DR UCSC; uc002mzn.4; human. [Q96JL9-1]
DR CTD; 84449; -.
DR GeneCards; ZNF333; -.
DR HGNC; HGNC:15624; ZNF333.
DR HPA; HPA043973; -.
DR HPA; HPA054680; -.
DR MIM; 611811; gene.
DR neXtProt; NX_Q96JL9; -.
DR OpenTargets; ENSG00000160961; -.
DR PharmGKB; PA134929553; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00840000129830; -.
DR HOGENOM; HOG000143390; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q96JL9; -.
DR KO; K09228; -.
DR OMA; FQYQRIH; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q96JL9; -.
DR TreeFam; TF350814; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR ChiTaRS; ZNF333; human.
DR GenomeRNAi; 84449; -.
DR PRO; PR:Q96JL9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000160961; -.
DR CleanEx; HS_ZNF333; -.
DR ExpressionAtlas; Q96JL9; baseline and differential.
DR Genevisible; Q96JL9; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 2.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR003656; Znf_BED.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01352; KRAB; 2.
DR SMART; SM00349; KRAB; 2.
DR SMART; SM00614; ZnF_BED; 2.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 2.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 665 Zinc finger protein 333.
FT /FTId=PRO_0000047536.
FT DOMAIN 4 74 KRAB 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT DOMAIN 203 274 KRAB 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 366 388 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 394 416 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 422 444 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 450 472 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 478 500 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 506 528 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 534 556 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 562 584 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 590 612 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 618 640 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 142 182 GLKAAMQIQRVVIPVPTLGHRNPWVARDSAVPARDPAWLQE
FT -> LPLLSLLLPSCPEPPLVLLDSSSAPDRHLGSTLDTEAR
FT GIP (in isoform 2).
FT {ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_055945.
FT VAR_SEQ 183 665 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_055946.
FT VAR_SEQ 301 302 EQ -> PPN (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_055947.
FT VAR_SEQ 303 665 Missing (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_055948.
FT VARIANT 251 251 A -> E (in dbSNP:rs3885179).
FT /FTId=VAR_024210.
FT VARIANT 537 537 A -> V (in dbSNP:rs3764626).
FT /FTId=VAR_052812.
FT CONFLICT 115 115 S -> P (in Ref. 3; AAH48107).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 590 612 ismart:ZnF_C2H2 [T]
FT MYHIT 394 421 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 203 263 ismart:KRAB [T]
FT MYHIT 590 617 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 366 388 ismart:ZnF_C2H2 [T]
FT MYHIT 618 645 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 422 444 ismart:ZnF_C2H2 [T]
FT MYHIT 592 612 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 515 559 ismart:ZnF_BED [T]
FT MYHIT 368 388 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 203 274 iprf:KRAB [T]
FT MYHIT 508 528 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 422 449 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 450 472 ismart:ZnF_C2H2 [T]
FT MYHIT 534 561 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 4 74 iprf:KRAB [T]
FT MYHIT 394 416 ismart:ZnF_C2H2 [T]
FT MYHIT 452 472 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 536 556 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 506 533 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 562 584 ismart:ZnF_C2H2 [T]
FT MYHIT 620 640 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 564 584 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 450 477 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 562 589 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 376 419 ismart:ZnF_BED [T]
FT MYHIT 478 505 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 3 43 ipfam:KRAB [T]
FT MYHIT 396 416 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 618 640 ismart:ZnF_C2H2 [T]
FT MYHIT 534 556 ismart:ZnF_C2H2 [T]
FT MYHIT 424 444 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 506 528 ismart:ZnF_C2H2 [T]
FT MYHIT 4 63 ismart:KRAB [T]
FT MYHIT 366 393 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 480 500 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 202 242 ipfam:KRAB [T]
FT MYHIT 478 500 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 665 AA; 75544 MW; EE5ABF8468D8DD24 CRC64;
MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS CVSQLGQRAE
PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM QMGPGLFLRM QLVPSIEERE
TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ RVVIPVPTLG HRNPWVARDS AVPARDPAWL
QEDKVEEEAM APGLPTACSQ EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA
SVADQLCKPN ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG
EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS AHLIVPEKIR
SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG QAFKYSSNLR RHMRTHTGEK
PFECSQCGKT FTRNFNLILH QRNHTGEKPY ECKDCGKAFN QPSSLRSHVR THTGEKPFEC
SQCGKAFREH SSLKTHLRTH TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG
QVLSRLSTLK SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG
QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS LPLSMSHPYC
GPLAN
//
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