ID ZN322_HUMAN Reviewed; 402 AA.
AC Q6U7Q0; A8K1X3; Q0VDH6; Q6B0G2; Q86W72; Q9H5I9;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 10-MAY-2017, entry version 118.
DE RecName: Full=Zinc finger protein 322;
DE AltName: Full=Zinc finger protein 322A;
DE AltName: Full=Zinc finger protein 388;
DE AltName: Full=Zinc finger protein 489;
GN Name=ZNF322; Synonyms=ZNF322A, ZNF388, ZNF489;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN TRANSCRIPTIONAL ACTIVATION,
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryonic heart;
RX PubMed=15555580; DOI=10.1016/j.bbrc.2004.10.183;
RA Li Y., Wang Y., Zhang C., Yuan W., Wang J., Zhu C., Chen L., Huang W.,
RA Zeng W., Wu X., Liu M.;
RT "ZNF322, a novel human C(2)H(2) Kruppel-like zinc-finger protein,
RT regulates transcriptional activation in MAPK signaling pathways.";
RL Biochem. Biophys. Res. Commun. 325:1383-1392(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hepatoma, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Involved in transcriptional regulation as an activator.
CC {ECO:0000269|PubMed:15555580}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15555580}.
CC Nucleus {ECO:0000269|PubMed:15555580}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart and
CC skeletal muscle. {ECO:0000269|PubMed:15555580}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo as early as the 11th week
CC of gestation. {ECO:0000269|PubMed:15555580}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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DR EMBL; AY376736; AAQ85127.1; -; mRNA.
DR EMBL; AK027046; BAB15637.1; ALT_INIT; mRNA.
DR EMBL; AK290038; BAF82727.1; -; mRNA.
DR EMBL; BC050425; AAH50425.2; -; mRNA.
DR EMBL; BC074772; AAH74772.1; -; mRNA.
DR EMBL; BC119669; AAI19670.1; -; mRNA.
DR CCDS; CCDS4617.1; -.
DR RefSeq; NP_001229726.1; NM_001242797.1.
DR RefSeq; NP_001229727.1; NM_001242798.1.
DR RefSeq; NP_001229728.1; NM_001242799.1.
DR RefSeq; NP_078915.2; NM_024639.4.
DR UniGene; Hs.126280; -.
DR UniGene; Hs.530271; -.
DR UniGene; Hs.709963; -.
DR ProteinModelPortal; Q6U7Q0; -.
DR SMR; Q6U7Q0; -.
DR BioGrid; 122813; 1.
DR STRING; 9606.ENSP00000418897; -.
DR iPTMnet; Q6U7Q0; -.
DR PhosphoSitePlus; Q6U7Q0; -.
DR BioMuta; ZNF322; -.
DR DMDM; 82582384; -.
DR MaxQB; Q6U7Q0; -.
DR PaxDb; Q6U7Q0; -.
DR PeptideAtlas; Q6U7Q0; -.
DR PRIDE; Q6U7Q0; -.
DR DNASU; 79692; -.
DR Ensembl; ENST00000415922; ENSP00000418897; ENSG00000181315.
DR Ensembl; ENST00000456172; ENSP00000478899; ENSG00000181315.
DR Ensembl; ENST00000471278; ENSP00000419728; ENSG00000181315.
DR Ensembl; ENST00000607204; ENSP00000483223; ENSG00000181315.
DR Ensembl; ENST00000622479; ENSP00000482607; ENSG00000181315.
DR GeneID; 79692; -.
DR KEGG; hsa:79692; -.
DR UCSC; uc003nil.4; human.
DR CTD; 79692; -.
DR DisGeNET; 79692; -.
DR GeneCards; ZNF322; -.
DR HGNC; HGNC:23640; ZNF322.
DR HPA; HPA043161; -.
DR HPA; HPA046692; -.
DR MIM; 610847; gene.
DR neXtProt; NX_Q6U7Q0; -.
DR OpenTargets; ENSG00000181315; -.
DR PharmGKB; PA134861342; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00790000123153; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q6U7Q0; -.
DR OMA; STCESGF; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q6U7Q0; -.
DR TreeFam; TF338126; -.
DR ChiTaRS; ZNF322; human.
DR GenomeRNAi; 79692; -.
DR PRO; PR:Q6U7Q0; -.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000181315; -.
DR CleanEx; HS_ZNF322A; -.
DR ExpressionAtlas; Q6U7Q0; baseline and differential.
DR Genevisible; Q6U7Q0; HS.
DR GO; GO:0005813; C:centrosome; IDA:HPA.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:HPA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Activator; Complete proteome; Cytoplasm; DNA-binding; Metal-binding;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 402 Zinc finger protein 322.
FT /FTId=PRO_0000047529.
FT ZN_FING 43 65 C2H2-type 1; atypical.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 71 93 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 99 121 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 127 149 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 155 177 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 183 205 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 211 233 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 239 261 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 267 289 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 293 315 C2H2-type 10; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 351 373 C2H2-type 11; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT MOD_RES 391 391 Phosphoserine.
FT {ECO:0000244|PubMed:23186163}.
FT CONFLICT 33 33 H -> R (in Ref. 1; AAQ85127).
FT {ECO:0000305}.
FT CONFLICT 73 73 C -> S (in Ref. 2; BAB15637).
FT {ECO:0000305}.
FT CONFLICT 94 94 N -> H (in Ref. 1; AAQ85127).
FT {ECO:0000305}.
FT CONFLICT 101 101 C -> R (in Ref. 1; AAQ85127).
FT {ECO:0000305}.
FT CONFLICT 373 373 H -> R (in Ref. 1; AAQ85127).
FT {ECO:0000305}.
FT CONFLICT 398 398 A -> V (in Ref. 1; AAQ85127).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 211 233 ismart:ZnF_C2H2 [T]
FT MYHIT 155 182 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 71 93 ismart:ZnF_C2H2 [T]
FT MYHIT 267 290 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 267 289 ismart:ZnF_C2H2 [T]
FT MYHIT 351 373 ismart:ZnF_C2H2 [T]
FT MYHIT 101 121 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 293 320 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 185 205 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 129 149 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 73 93 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 183 205 ismart:ZnF_C2H2 [T]
FT MYHIT 43 70 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 99 121 ismart:ZnF_C2H2 [T]
FT MYHIT 155 177 ismart:ZnF_C2H2 [T]
FT MYHIT 127 149 ismart:ZnF_C2H2 [T]
FT MYHIT 241 261 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 99 126 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 127 154 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 293 315 ismart:ZnF_C2H2 [T]
FT MYHIT 157 177 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 43 65 ismart:ZnF_C2H2 [T]
FT MYHIT 213 233 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 183 210 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 351 378 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 211 238 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 239 266 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 239 261 ismart:ZnF_C2H2 [T]
FT MYHIT 71 98 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 402 AA; 46941 MW; A9A54EC8884BD27D CRC64;
MYTSEEKCNQ RTQKRKIYNV CPRKGKKIFI HMHEIIQIDG HIYQCLECKQ NFCENLALIM
CERTHTGEKP YKCDMCEKTF VQSSDLTSHQ RIHNYEKPYK CSKCEKSFWH HLALSGHQRT
HAGKKFYTCD ICGKNFGQSS DLLVHQRSHT GEKPYLCSEC DKCFSRSTNL IRHRRTHTGE
KPFKCLECEK AFSGKSDLIS HQRTHTGERP YKCNKCEKSY RHRSAFIVHK RVHTGEKPYK
CGACEKCFGQ KSDLIVHQRV HTGEKPYKCL ECMRSFTRSA NLIRHQATHT HTFKCLEYEK
SFNCSSDLIV HQRIHMEEKP HQWSACESGF LLGMDFVAQQ KMRTQTEELH YKYTVCDKSF
HQSSALLQHQ TVHIGEKPFV CNVSEKGLEL SPPHASEASQ MS
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