ID ZN285_HUMAN Reviewed; 590 AA.
AC Q96NJ3; Q17RJ3; Q6B0A8; Q6ISR5;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 10-MAY-2017, entry version 131.
DE RecName: Full=Zinc finger protein 285;
DE AltName: Full=Zinc finger protein 285A;
GN Name=ZNF285; Synonyms=ZNF285A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS
RP SER-208 AND GLY-536.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
RP VARIANTS SER-208 AND GLY-536.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96NJ3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96NJ3-2; Sequence=VSP_037502;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK055309; BAB70901.1; -; mRNA.
DR EMBL; AC138473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117300; AAI17301.1; -; mRNA.
DR EMBL; BC117302; AAI17303.1; -; mRNA.
DR EMBL; BC069384; AAH69384.2; -; mRNA.
DR EMBL; BC074875; AAH74875.2; -; mRNA.
DR CCDS; CCDS12638.1; -. [Q96NJ3-1]
DR RefSeq; NP_001278417.1; NM_001291488.1.
DR RefSeq; NP_001278418.1; NM_001291489.1.
DR RefSeq; NP_001278419.1; NM_001291490.1.
DR RefSeq; NP_001278420.1; NM_001291491.1.
DR RefSeq; NP_689567.4; NM_152354.5.
DR UniGene; Hs.709428; -.
DR ProteinModelPortal; Q96NJ3; -.
DR SMR; Q96NJ3; -.
DR STRING; 9606.ENSP00000333595; -.
DR iPTMnet; Q96NJ3; -.
DR PhosphoSitePlus; Q96NJ3; -.
DR BioMuta; ZNF285; -.
DR DMDM; 239938813; -.
DR EPD; Q96NJ3; -.
DR PaxDb; Q96NJ3; -.
DR PeptideAtlas; Q96NJ3; -.
DR PRIDE; Q96NJ3; -.
DR DNASU; 26974; -.
DR Ensembl; ENST00000544719; ENSP00000439431; ENSG00000267508.
DR Ensembl; ENST00000614994; ENSP00000483662; ENSG00000267508.
DR GeneID; 26974; -.
DR KEGG; hsa:26974; -.
DR UCSC; uc002ozd.5; human. [Q96NJ3-1]
DR CTD; 26974; -.
DR GeneCards; ZNF285; -.
DR HGNC; HGNC:13079; ZNF285.
DR HPA; HPA046100; -.
DR HPA; HPA049212; -.
DR neXtProt; NX_Q96NJ3; -.
DR PharmGKB; PA165394833; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q96NJ3; -.
DR KO; K09228; -.
DR PhylomeDB; Q96NJ3; -.
DR TreeFam; TF350845; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 26974; -.
DR PRO; PR:Q96NJ3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000267508; -.
DR CleanEx; HS_ZNF285A; -.
DR ExpressionAtlas; Q96NJ3; baseline and differential.
DR Genevisible; Q96NJ3; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 590 Zinc finger protein 285.
FT /FTId=PRO_0000378106.
FT DOMAIN 8 86 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 232 254 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 260 282 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 316 338 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 344 366 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 372 394 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 400 422 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 428 450 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 456 478 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 484 506 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 512 534 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 540 562 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 1 155 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_037502.
FT VARIANT 208 208 N -> S (in dbSNP:rs2571089).
FT {ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_057972.
FT VARIANT 536 536 R -> G (in dbSNP:rs12610859).
FT {ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_057973.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 486 506 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 456 483 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 232 259 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 260 282 ismart:ZnF_C2H2 [T]
FT MYHIT 346 366 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 318 338 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 428 450 ismart:ZnF_C2H2 [T]
FT MYHIT 428 455 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 400 427 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 372 399 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 8 65 ismart:KRAB [T]
FT MYHIT 512 534 ismart:ZnF_C2H2 [T]
FT MYHIT 260 287 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 540 562 ismart:ZnF_C2H2 [T]
FT MYHIT 400 422 ismart:ZnF_C2H2 [T]
FT MYHIT 540 567 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 514 534 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 402 422 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 374 394 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 372 394 ismart:ZnF_C2H2 [T]
FT MYHIT 430 450 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 512 539 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 232 254 ismart:ZnF_C2H2 [T]
FT MYHIT 344 371 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 234 254 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 8 86 iprf:KRAB [T]
FT MYHIT 484 506 ismart:ZnF_C2H2 [T]
FT MYHIT 542 562 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 484 511 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 344 366 ismart:ZnF_C2H2 [T]
FT MYHIT 316 343 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 458 478 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 456 478 ismart:ZnF_C2H2 [T]
FT MYHIT 8 46 ipfam:KRAB [T]
FT MYHIT 316 338 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 590 AA; 68261 MW; 0A3F51DEE2396462 CRC64;
MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG IKNNILNLQA
KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP HLEDVSLSEE WAGISLQISE
NENYVVNAII KNQDITAWQS LTQVLTPESW RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ
HDDSLSWTSC DHHESQECKG EDPGRHPNCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA
FADDTDPHVH HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS
SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG KGFGFRSLLC
IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY KCSECGKCFS SSSVLQVHWR
FHTGEKPYRC GECGKGFSQC THLHIHQRVH TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG
EKPYKCEVCG KCFSYSSYFH LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTRERPY
KCKACGKGFS RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL
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