ID ZN276_MOUSE Reviewed; 614 AA.
AC Q8CE64; Q3TQL7; Q3V088; Q80ZN3; Q8C912; Q9ESV2;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 3.
DT 10-MAY-2017, entry version 119.
DE RecName: Full=Zinc finger protein 276;
DE Short=Zfp-276;
GN Name=Znf276; Synonyms=Zfp276;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RC TISSUE=Cerebellum, Corpora quadrigemina, Skin, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 149-614 (ISOFORM 1), TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J;
RX PubMed=10936049; DOI=10.1006/geno.2000.6252;
RA Wong J.C., Alon N., Norga K., Kruyt F.A.E., Youssoufian H.,
RA Buchwald M.;
RT "Cloning and analysis of the mouse Fanconi anemia group A cDNA and an
RT overlapping penta zinc finger cDNA.";
RL Genomics 67:273-283(2000).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.O113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
RA Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
RA Vemulapalli V., Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome,
CC centromere, kinetochore {ECO:0000250|UniProtKB:Q8N554}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CE64-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CE64-2; Sequence=VSP_026106, VSP_026107;
CC -!- TISSUE SPECIFICITY: Found in all the examined tissues, with
CC highest levels in kidney, liver, lung, and spleen.
CC {ECO:0000269|PubMed:10936049}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels in all stages of
CC embryonic development examined. {ECO:0000269|PubMed:10936049}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG01634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC Sequence=BAC31505.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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DR EMBL; AK028939; BAC26204.1; -; mRNA.
DR EMBL; AK043258; BAC31505.1; ALT_INIT; mRNA.
DR EMBL; AK133363; BAE21616.1; -; mRNA.
DR EMBL; AK163486; BAE37365.1; -; mRNA.
DR EMBL; AF178935; AAG01634.1; ALT_INIT; mRNA.
DR CCDS; CCDS52699.1; -. [Q8CE64-1]
DR RefSeq; NP_065243.2; NM_020497.2. [Q8CE64-1]
DR UniGene; Mm.379084; -.
DR ProteinModelPortal; Q8CE64; -.
DR SMR; Q8CE64; -.
DR BioGrid; 208217; 1.
DR STRING; 10090.ENSMUSP00000001092; -.
DR iPTMnet; Q8CE64; -.
DR PhosphoSitePlus; Q8CE64; -.
DR PaxDb; Q8CE64; -.
DR PeptideAtlas; Q8CE64; -.
DR PRIDE; Q8CE64; -.
DR Ensembl; ENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065. [Q8CE64-1]
DR GeneID; 57247; -.
DR KEGG; mmu:57247; -.
DR UCSC; uc009nva.2; mouse. [Q8CE64-2]
DR UCSC; uc009nvb.2; mouse. [Q8CE64-1]
DR CTD; 57247; -.
DR MGI; MGI:1888495; Zfp276.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000063153; -.
DR HOGENOM; HOG000155790; -.
DR HOVERGEN; HBG061026; -.
DR InParanoid; Q8CE64; -.
DR OMA; GCDQGHD; -.
DR OrthoDB; EOG091G04WK; -.
DR PhylomeDB; Q8CE64; -.
DR TreeFam; TF332664; -.
DR PRO; PR:Q8CE64; -.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000001065; -.
DR CleanEx; MM_ZFP276; -.
DR ExpressionAtlas; Q8CE64; baseline and differential.
DR Genevisible; Q8CE64; MM.
DR GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF07776; zf-AD; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Centromere; Chromosome; Complete proteome;
KW DNA-binding; Kinetochore; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 614 Zinc finger protein 276.
FT /FTId=PRO_0000047324.
FT DOMAIN 79 153 ZAD.
FT ZN_FING 434 458 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 465 490 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 496 518 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 524 546 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 554 577 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 337 350 QLGETQVPSSTSDD -> KQHLWLMLEQDSVF (in
FT isoform 2).
FT {ECO:0000303|PubMed:16141072}.
FT /FTId=VSP_026106.
FT VAR_SEQ 351 614 Missing (in isoform 2).
FT {ECO:0000303|PubMed:16141072}.
FT /FTId=VSP_026107.
FT CONFLICT 353 353 K -> R (in Ref. 1; BAC26204).
FT {ECO:0000305}.
FT CONFLICT 509 510 KH -> ND (in Ref. 2; AAG01634).
FT {ECO:0000305}.
FT CONFLICT 521 521 A -> G (in Ref. 2; AAG01634).
FT {ECO:0000305}.
FT CONFLICT 579 579 L -> W (in Ref. 2; AAG01634).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 496 523 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 436 459 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 554 577 ismart:ZnF_C2H2 [T]
FT MYHIT 524 546 ismart:ZnF_C2H2 [T]
FT MYHIT 498 518 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 556 577 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 524 551 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 554 582 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 434 458 ismart:ZnF_C2H2 [T]
FT MYHIT 465 495 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 79 156 ipfam:zf-AD [T]
FT MYHIT 496 518 ismart:ZnF_C2H2 [T]
FT MYHIT 465 490 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 614 AA; 67339 MW; 1F5716CFADE16533 CRC64;
MKRDRLGRFL SPGIARQRGG SGGGCGSGRT RGRPSRSGGT SADGAAAQLS WGSMTRSCGD
TGDDGTDEAG AGRTLAMGHC RLCHGKFSSR SLRSISDRVP GETSERLSPG ERVFIRDFQR
LLGVAVHQDP ALPQSVCKNC YTQFYQCHSL LRTFLQRVNV SPAGQRKPCT KVGVQPTTVA
EEGACVADLI ASSPRCLHGL VGWVHEHAVS CGSLPSLQRT LSSEYCGIIQ AVWGCDQGHD
FTMDTASSCR ALFLDSALAV KWAWGKDLSP RLAQNSESNP TGAASRLCQA RETQVGSETK
TLPSVDVALL HSHGDSVGPG LGPCTQPHLA PSEAPGQLGE TQVPSSTSDD RVKDEFSDLS
EGDFLSEDES DKKQTPQSSD ESFEPYPEKK VSGKKSEGRE AKRPEEPKIR KKPGPKPGWK
KKLRCEREEL PTIYKCPYQG CTAVYRGADG MKKHIKEHHE EVRERPCPHP GCNKVFMIDR
YLQRHVKLIH TEVRNYICDE CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK
YHMTKHKAET ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QAQDRALPLE AEPPPGPLSP
SGTMEGQAVK PEPT
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