ID ZN276_HUMAN Reviewed; 614 AA.
AC Q8N554; Q0VGA1; Q2TBE8; Q3B7H7;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 4.
DT 10-MAY-2017, entry version 121.
DE RecName: Full=Zinc finger protein 276;
DE Short=Zfp-276;
DE AltName: Full=Zinc finger protein 477;
GN Name=ZNF276; Synonyms=CENP-Z, ZFP276, ZNF477;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANTS ARG-263; TRP-275;
RP TRP-351 AND ASP-605.
RX PubMed=14605947; DOI=10.1007/s10038-003-0088-1;
RA Wong J.C., Gokgoz N., Alon N., Andrulis I.L., Buchwald M.;
RT "Cloning and mutation analysis of ZFP276 as a candidate tumor
RT suppressor in breast cancer.";
RL J. Hum. Genet. 48:668-671(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 64-614 (ISOFORM 1), AND VARIANT
RP ARG-263.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-351 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=20813266; DOI=10.1016/j.cell.2010.07.047;
RA Ohta S., Bukowski-Wills J.C., Sanchez-Pulido L., Alves Fde L.,
RA Wood L., Chen Z.A., Platani M., Fischer L., Hudson D.F., Ponting C.P.,
RA Fukagawa T., Earnshaw W.C., Rappsilber J.;
RT "The protein composition of mitotic chromosomes determined using
RT multiclassifier combinatorial proteomics.";
RL Cell 142:810-821(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96CN9:GCC1; NbExp=3; IntAct=EBI-10265849, EBI-746252;
CC Q96BR9:ZBTB8A; NbExp=6; IntAct=EBI-750821, EBI-742740;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome,
CC centromere, kinetochore {ECO:0000269|PubMed:20813266}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N554-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N554-2; Sequence=VSP_026104;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32781.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC Sequence=AAI10349.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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DR EMBL; AF354755; AAQ15128.1; -; mRNA.
DR EMBL; AF354756; AAQ15129.1; -; mRNA.
DR EMBL; AC005360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032781; AAH32781.2; ALT_INIT; mRNA.
DR EMBL; BC107603; AAI07604.1; -; mRNA.
DR EMBL; BC110348; AAI10349.1; ALT_INIT; mRNA.
DR EMBL; AK026482; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS10986.1; -. [Q8N554-2]
DR CCDS; CCDS45554.1; -. [Q8N554-1]
DR RefSeq; NP_001106997.1; NM_001113525.1. [Q8N554-1]
DR RefSeq; NP_689500.2; NM_152287.3. [Q8N554-2]
DR UniGene; Hs.290154; -.
DR ProteinModelPortal; Q8N554; -.
DR SMR; Q8N554; -.
DR BioGrid; 124982; 3.
DR IntAct; Q8N554; 5.
DR MINT; MINT-1471309; -.
DR STRING; 9606.ENSP00000415836; -.
DR iPTMnet; Q8N554; -.
DR PhosphoSitePlus; Q8N554; -.
DR BioMuta; ZNF276; -.
DR DMDM; 296453082; -.
DR EPD; Q8N554; -.
DR MaxQB; Q8N554; -.
DR PaxDb; Q8N554; -.
DR PeptideAtlas; Q8N554; -.
DR PRIDE; Q8N554; -.
DR DNASU; 92822; -.
DR Ensembl; ENST00000289816; ENSP00000289816; ENSG00000158805. [Q8N554-2]
DR Ensembl; ENST00000443381; ENSP00000415836; ENSG00000158805. [Q8N554-1]
DR GeneID; 92822; -.
DR KEGG; hsa:92822; -.
DR UCSC; uc002foq.5; human. [Q8N554-1]
DR CTD; 92822; -.
DR DisGeNET; 92822; -.
DR GeneCards; ZNF276; -.
DR HGNC; HGNC:23330; ZNF276.
DR HPA; HPA021309; -.
DR HPA; HPA022255; -.
DR MIM; 608460; gene.
DR neXtProt; NX_Q8N554; -.
DR OpenTargets; ENSG00000158805; -.
DR PharmGKB; PA134935042; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000063153; -.
DR HOGENOM; HOG000155790; -.
DR HOVERGEN; HBG061026; -.
DR InParanoid; Q8N554; -.
DR OMA; GCDQGHD; -.
DR OrthoDB; EOG091G04WK; -.
DR PhylomeDB; Q8N554; -.
DR TreeFam; TF332664; -.
DR ChiTaRS; ZNF276; human.
DR GenomeRNAi; 92822; -.
DR PRO; PR:Q8N554; -.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000158805; -.
DR CleanEx; HS_ZNF276; -.
DR ExpressionAtlas; Q8N554; baseline and differential.
DR Genevisible; Q8N554; HS.
DR GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF07776; zf-AD; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Centromere; Chromosome; Complete proteome;
KW DNA-binding; Kinetochore; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 614 Zinc finger protein 276.
FT /FTId=PRO_0000047323.
FT DOMAIN 79 153 ZAD.
FT ZN_FING 434 458 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 465 490 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 496 518 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 524 546 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 554 577 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 1 75 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14605947,
FT ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_026104.
FT VARIANT 263 263 W -> R (in dbSNP:rs6500437).
FT {ECO:0000269|PubMed:14605947,
FT ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_032708.
FT VARIANT 275 275 R -> W (may increase breast cancer risk).
FT {ECO:0000269|PubMed:14605947}.
FT /FTId=VAR_019125.
FT VARIANT 351 351 R -> W (in dbSNP:rs17719249).
FT {ECO:0000269|PubMed:14605947}.
FT /FTId=VAR_032709.
FT VARIANT 605 605 E -> D (in dbSNP:rs17227424).
FT {ECO:0000269|PubMed:14605947}.
FT /FTId=VAR_019126.
FT CONFLICT 104 104 E -> V (in Ref. 2; AK026482).
FT {ECO:0000305}.
FT CONFLICT 180 180 E -> G (in Ref. 2; AK026482).
FT {ECO:0000305}.
FT CONFLICT 413 413 P -> Q (in Ref. 3; AAQ15128/AAQ15129).
FT {ECO:0000305}.
FT CONFLICT 434 434 Y -> H (in Ref. 1; AAI07604).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 78 155 ipfam:zf-AD [T]
FT MYHIT 496 523 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 498 518 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 465 495 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 524 551 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 434 458 ismart:ZnF_C2H2 [T]
FT MYHIT 556 577 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 465 490 ismart:ZnF_C2H2 [T]
FT MYHIT 554 577 ismart:ZnF_C2H2 [T]
FT MYHIT 436 459 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 496 518 ismart:ZnF_C2H2 [T]
FT MYHIT 524 546 ismart:ZnF_C2H2 [T]
FT MYHIT 554 582 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 614 AA; 67219 MW; D63256CFD7DC5040 CRC64;
MKRDRLGRFL SPGSSRQCGA SDGGGGVSRT RGRPSLSGGP RVDGATARRA WGPVGSCGDA
GEDGADEAGA GRALAMGHCR LCHGKFSSRS LRSISERAPG ASMERPSAEE RVLVRDFQRL
LGVAVRQDPT LSPFVCKSCH AQFYQCHSLL KSFLQRVNAS PAGRRKPCAK VGAQPPTGAE
EGACLVDLIT SSPQCLHGLV GWVHGHAASC GALPHLQRTL SSEYCGVIQV VWGCDQGHDY
TMDTSSSCKA FLLDSALAVK WPWDKETAPR LPQHRGWNPG DAPQTSQGRG TGTPVGAETK
TLPSTDVAQP PSDSDAVGPR SGFPPQPSLP LCRAPGQLGE KQLPSSTSDD RVKDEFSDLS
EGDVLSEDEN DKKQNAQSSD ESFEPYPERK VSGKKSESKE AKKSEEPRIR KKPGPKPGWK
KKLRCEREEL PTIYKCPYQG CTAVYRGADG MKKHIKEHHE EVRERPCPHP GCNKVFMIDR
YLQRHVKLIH TEVRNYICDE CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK
YHMTKHKAET ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QTQDKALPLE AEPPPGPPSP
SVTTEGQAVK PEPT
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