ID ZN275_HUMAN Reviewed; 429 AA.
AC Q9NSD4; A6NE92;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 10-MAY-2017, entry version 137.
DE RecName: Full=Zinc finger protein 275;
GN Name=ZNF275;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10854409; DOI=10.1101/gr.10.6.758;
RA Mallon A.-M., Platzer M., Bate R., Gloeckner G., Botcherby M.R.M.,
RA Nordsiek G., Strivens M.A., Kioschis P., Dangel A., Cunningham D.,
RA Straw R.N.A., Weston P., Gilbert M., Fernando S., Goodall K.,
RA Hunter G., Greystrong J.S., Clarke D., Kimberley C., Goerdes M.,
RA Blechschmidt K., Rump A., Hinzmann B., Mundy C.R., Miller W.,
RA Poustka A., Herman G.E., Rhodes M., Denny P., Rosenthal A.,
RA Brown S.D.M.;
RT "Comparative genome sequence analysis of the Bpa/Str region in mouse
RT and man.";
RL Genome Res. 10:758-775(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NSD4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NSD4-2; Sequence=VSP_055944;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U82670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC152007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC152008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471172; EAW72883.1; -; Genomic_DNA.
DR EMBL; BC136634; AAI36635.1; -; mRNA.
DR UniGene; Hs.348963; -.
DR ProteinModelPortal; Q9NSD4; -.
DR SMR; Q9NSD4; -.
DR BioGrid; 116051; 1.
DR STRING; 9606.ENSP00000411097; -.
DR iPTMnet; Q9NSD4; -.
DR PhosphoSitePlus; Q9NSD4; -.
DR DMDM; 308153531; -.
DR MaxQB; Q9NSD4; -.
DR PaxDb; Q9NSD4; -.
DR PeptideAtlas; Q9NSD4; -.
DR PRIDE; Q9NSD4; -.
DR Ensembl; ENST00000370249; ENSP00000359269; ENSG00000063587. [Q9NSD4-2]
DR UCSC; uc065bsr.1; human. [Q9NSD4-1]
DR GeneCards; ZNF275; -.
DR HGNC; HGNC:13069; ZNF275.
DR HPA; HPA000566; -.
DR neXtProt; NX_Q9NSD4; -.
DR OpenTargets; ENSG00000063587; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00840000130038; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q9NSD4; -.
DR OMA; GDCRKVF; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q9NSD4; -.
DR ChiTaRS; ZNF275; human.
DR GenomeRNAi; 10838; -.
DR PRO; PR:Q9NSD4; -.
DR Proteomes; UP000005640; Chromosome X.
DR Bgee; ENSG00000063587; -.
DR CleanEx; HS_ZNF275; -.
DR ExpressionAtlas; Q9NSD4; baseline and differential.
DR Genevisible; Q9NSD4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 429 Zinc finger protein 275.
FT /FTId=PRO_0000047502.
FT ZN_FING 101 123 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 129 151 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 181 203 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 209 231 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 237 259 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 265 287 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 293 315 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 321 343 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 349 371 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 377 399 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 405 427 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT MOD_RES 76 76 Phosphoserine.
FT {ECO:0000244|PubMed:23186163}.
FT VAR_SEQ 1 53 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_055944.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 379 399 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 405 429 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 239 259 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 377 399 ismart:ZnF_C2H2 [T]
FT MYHIT 211 231 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 265 287 ismart:ZnF_C2H2 [T]
FT MYHIT 323 343 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 181 203 ismart:ZnF_C2H2 [T]
FT MYHIT 181 208 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 265 292 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 295 315 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 129 151 ismart:ZnF_C2H2 [T]
FT MYHIT 101 123 ismart:ZnF_C2H2 [T]
FT MYHIT 293 315 ismart:ZnF_C2H2 [T]
FT MYHIT 131 151 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 293 320 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 321 343 ismart:ZnF_C2H2 [T]
FT MYHIT 377 404 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 349 376 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 351 371 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 405 427 ismart:ZnF_C2H2 [T]
FT MYHIT 129 156 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 321 348 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 267 287 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 183 203 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 405 428 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 349 371 ismart:ZnF_C2H2 [T]
FT MYHIT 101 128 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 237 264 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 103 123 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 237 259 ismart:ZnF_C2H2 [T]
FT MYHIT 209 236 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 209 231 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 429 AA; 48443 MW; 85601FAC3129FB3A CRC64;
MMSHPCVSLL GVPVLNPALV PHLAQGQVLL VSDPSPNTDP AKYSESTSAT RHQMKGEDAQ
PQEMASTSFP RASGPSPEFR QHGDSDGKRG SPQNLPIEHH FACKECGDTF RLKVLLVQHQ
RVHSEEKGWE CGDCGKVFRG VAEFNEHRKS HVAAEPQPGP SRALENAAEK REQMEREAKP
FECEECGKRF KKNAGLSQHL RVHSREKPFD CEECGRSFKV NTHLFRHQKL HTSEKPFACK
ACSRDFLDRQ ELLKHQRMHT GHLPFDCDDC GKSFRGVNGL AEHQRIHSGA KPYGCPHCGK
LFRRSSELTK HRRIHTGEKP YACGQCGKAF RQSSSLLEHA RIHSGERPYA CGECGKAFRG
PSDLIKHRRI HSGLKPYECD KCGKAFRRSS GLSRHRRIHS GARRCECSQC GRVFKRRSAL
QKHQPTHHE
//
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