Legends: 1, CONFLICT D -> H (in Ref. 2; AAA40583). {ECO:0000305}; 2, ZN_FING C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042}; 3, ZN_FING C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042}; 4, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ZN_FING C2H2-type 13. {ECO:0000255|PROSITE- ProRule:PRU00042}; 15, ZN_FING C2H2-type 14. {ECO:0000255|PROSITE- ProRule:PRU00042}; 16, ZN_FING C2H2-type 15. {ECO:0000255|PROSITE- ProRule:PRU00042}; 17, ZN_FING C2H2-type 16. {ECO:0000255|PROSITE- ProRule:PRU00042}; 18, ZN_FING C2H2-type 17. {ECO:0000255|PROSITE- ProRule:PRU00042}; 19, ZN_FING C2H2-type 18. {ECO:0000255|PROSITE- ProRule:PRU00042}; 20, COMPBIAS Asp/Glu-rich (acidic); 21, iprf:ZINC_FINGER_C2H2_2 [T]; 22, ipat:ZINC_FINGER_C2H2_1 [T]; 23, ismart:ZnF_C2H2 [T].
|
ID ZN271_MOUSE Reviewed; 580 AA.
AC P15620;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 10-MAY-2017, entry version 142.
DE RecName: Full=Zinc finger protein 271;
DE AltName: Full=Zinc finger protein 35;
DE Short=Zfp-35;
GN Name=Znf271; Synonyms=Zfp-35, Zfp35;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=MF1; TISSUE=Testis;
RX PubMed=2104800;
RA Cunliffe V.T., Koopman P., McLaren A., Trowsdale J.;
RT "A mouse zinc finger gene which is transiently expressed during
RT spermatogenesis.";
RL EMBO J. 9:197-205(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2249852; DOI=10.1016/0888-7543(90)90290-B;
RA Cunliffe V., Williams S., Trowsdale J.;
RT "Genomic analysis of a mouse zinc finger gene, Zfp-35, that is up-
RT regulated during spermatogenesis.";
RL Genomics 8:331-339(1990).
CC -!- FUNCTION: May act to control gene activity during the pachytene
CC stage of meiotic prophase. May function as a transcription
CC activator.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Selectively expressed in adult testis.
CC {ECO:0000269|PubMed:2104800}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X17617; CAA35618.1; -; mRNA.
DR EMBL; M36146; AAA40583.1; -; Genomic_DNA.
DR EMBL; M36145; AAA40583.1; JOINED; Genomic_DNA.
DR CCDS; CCDS29097.1; -.
DR PIR; A37107; A37107.
DR RefSeq; NP_035885.2; NM_011755.2.
DR UniGene; Mm.290596; -.
DR ProteinModelPortal; P15620; -.
DR SMR; P15620; -.
DR STRING; 10090.ENSMUSP00000074475; -.
DR iPTMnet; P15620; -.
DR PhosphoSitePlus; P15620; -.
DR PaxDb; P15620; -.
DR PRIDE; P15620; -.
DR Ensembl; ENSMUST00000074941; ENSMUSP00000074475; ENSMUSG00000063281.
DR GeneID; 22694; -.
DR KEGG; mmu:22694; -.
DR UCSC; uc008egk.1; mouse.
DR CTD; 22694; -.
DR MGI; MGI:99179; Zfp35.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00870000136370; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; P15620; -.
DR OMA; FCEFGDK; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; P15620; -.
DR TreeFam; TF341817; -.
DR PRO; PR:P15620; -.
DR Proteomes; UP000000589; Chromosome 18.
DR Bgee; ENSMUSG00000063281; -.
DR CleanEx; MM_ZFP35; -.
DR ExpressionAtlas; P15620; baseline and differential.
DR Genevisible; P15620; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IMP:MGI.
DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IMP:MGI.
DR GO; GO:0002829; P:negative regulation of type 2 immune response; IMP:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 2: Evidence at transcript level;
KW Activator; Complete proteome; Developmental protein; Differentiation;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Spermatogenesis; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1 580 Zinc finger protein 271.
FT /FTId=PRO_0000047497.
FT ZN_FING 78 100 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 104 126 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 132 154 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 160 182 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 188 210 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 216 238 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 244 266 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 272 294 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 300 322 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 328 350 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 356 378 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 384 406 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 412 434 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 440 462 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 468 490 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 496 518 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 524 545 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 551 573 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT COMPBIAS 1 77 Asp/Glu-rich (acidic).
FT CONFLICT 370 370 D -> H (in Ref. 2; AAA40583).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 524 550 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 470 490 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 78 100 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 272 294 ismart:ZnF_C2H2 [T]
FT MYHIT 188 215 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 162 182 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 78 100 ismart:ZnF_C2H2 [T]
FT MYHIT 134 154 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 553 573 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 412 434 ismart:ZnF_C2H2 [T]
FT MYHIT 132 154 ismart:ZnF_C2H2 [T]
FT MYHIT 498 518 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 442 462 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 440 467 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 300 322 ismart:ZnF_C2H2 [T]
FT MYHIT 104 126 ismart:ZnF_C2H2 [T]
FT MYHIT 330 350 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 328 355 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 272 299 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 414 434 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 216 243 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 80 100 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 551 578 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 384 406 ismart:ZnF_C2H2 [T]
FT MYHIT 300 327 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 468 490 ismart:ZnF_C2H2 [T]
FT MYHIT 356 383 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 302 322 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 356 378 ismart:ZnF_C2H2 [T]
FT MYHIT 132 159 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 496 523 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 386 406 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 551 573 ismart:ZnF_C2H2 [T]
FT MYHIT 246 266 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 384 411 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 106 126 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 216 238 ismart:ZnF_C2H2 [T]
FT MYHIT 328 350 ismart:ZnF_C2H2 [T]
FT MYHIT 496 518 ismart:ZnF_C2H2 [T]
FT MYHIT 190 210 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 468 495 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 244 271 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 524 545 ismart:ZnF_C2H2 [T]
FT MYHIT 440 462 ismart:ZnF_C2H2 [T]
FT MYHIT 104 131 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 218 238 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 244 266 ismart:ZnF_C2H2 [T]
FT MYHIT 160 182 ismart:ZnF_C2H2 [T]
FT MYHIT 358 378 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 274 294 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 412 439 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 160 187 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 188 210 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 580 AA; 67036 MW; 11AA449913562B4C CRC64;
MEIQFSYESQ DHHFLSDGET KIKIGEPATE EEMTGKIGTV TEESGSLEED VPHDSRGKEF
REFGEELNDQ MLFRRRQYNC DECDQSFAWS TGLIRHQRTH WKPYECEECG KAFRMSSALV
LHQRIHTGEK PYPCSWCIKS FSRSSDLIKH QRVHTGEKPY KCDECGKAFS QSSDLMIHQR
IHTGEKPYQC SHCSKSFSQH SGMVKHLRIH TGEKPYMCNH CYKHFSQSSD LIKHQRIHTG
EKPYKCDVCG KAFSQSSDRI LHQRIHTGEK PYPCAQCNKS FSQNSDLIKH RRIHTGEKPY
KCSECGKAFN QSSVLILHQR IHTGEKPYPC NQCTKSFSRL SDLINHQRIH TGEKPYPCSQ
CSKMFSRRSD LVKHYRIHTG EKPYECDKCG KTFSQSSNLI LHQRIHTGEK PYPCNSCSKS
FSRGSDLIKH QRVHTGEKPY TCNLCSKSFS QSSDLTKHQR VHSGEKPYHC SSCNKAFRQS
SDLILHHRVH TGERPYACTQ CPRSFSQKSD LIKHQRIHTG EKPYKCMCGK AFSQCSAFTL
HQRIHTGEKP YPCAQCGKSF SQRSDLVNHQ RVHADQKLQM
//
|
