Entry euk:ZN142_HUMAN

ID   ZN142_HUMAN             Reviewed;        1687 AA.
AC   P52746; Q92510;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 4.
DT   10-MAY-2017, entry version 149.
DE   RecName: Full=Zinc finger protein 142;
DE   AltName: Full=HA4654;
GN   Name=ZNF142; Synonyms=KIAA0236;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-751.
RC   TISSUE=Bone marrow;
RX   PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA   Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA   Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. VI.
RT   The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by
RT   analysis of cDNA clones from cell line KG-1 and brain.";
RL   DNA Res. 3:321-329(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 460-632.
RC   TISSUE=Insulinoma;
RX   PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA   Tommerup N., Vissing H.;
RT   "Isolation and fine mapping of 16 novel human zinc finger-encoding
RT   cDNAs identify putative candidate genes for developmental and
RT   malignant disorders.";
RL   Genomics 27:259-264(1995).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [5]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-594, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25218447; DOI=10.1038/nsmb.2890;
RA   Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA   Vertegaal A.C.;
RT   "Uncovering global SUMOylation signaling networks in a site-specific
RT   manner.";
RL   Nat. Struct. Mol. Biol. 21:927-936(2014).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA13242.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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DR   EMBL; D87073; BAA13242.2; ALT_INIT; mRNA.
DR   EMBL; AC012510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U09849; AAC50265.1; -; mRNA.
DR   CCDS; CCDS42817.1; -.
DR   PIR; I38617; I38617.
DR   RefSeq; NP_001099007.1; NM_001105537.2.
DR   RefSeq; XP_011510091.1; XM_011511789.2.
DR   RefSeq; XP_016860361.1; XM_017004872.1.
DR   UniGene; Hs.657969; -.
DR   ProteinModelPortal; P52746; -.
DR   SMR; P52746; -.
DR   BioGrid; 113495; 8.
DR   IntAct; P52746; 2.
DR   STRING; 9606.ENSP00000398798; -.
DR   iPTMnet; P52746; -.
DR   PhosphoSitePlus; P52746; -.
DR   DMDM; 313104298; -.
DR   EPD; P52746; -.
DR   MaxQB; P52746; -.
DR   PaxDb; P52746; -.
DR   PeptideAtlas; P52746; -.
DR   PRIDE; P52746; -.
DR   Ensembl; ENST00000411696; ENSP00000398798; ENSG00000115568.
DR   Ensembl; ENST00000449707; ENSP00000408643; ENSG00000115568.
DR   GeneID; 7701; -.
DR   KEGG; hsa:7701; -.
DR   UCSC; uc002vin.6; human.
DR   CTD; 7701; -.
DR   DisGeNET; 7701; -.
DR   GeneCards; ZNF142; -.
DR   HGNC; HGNC:12927; ZNF142.
DR   HPA; HPA049594; -.
DR   MIM; 604083; gene.
DR   neXtProt; NX_P52746; -.
DR   OpenTargets; ENSG00000115568; -.
DR   PharmGKB; PA37514; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00850000132342; -.
DR   HOGENOM; HOG000015350; -.
DR   HOVERGEN; HBG074178; -.
DR   InParanoid; P52746; -.
DR   OMA; CPFSCQQ; -.
DR   OrthoDB; EOG091G008L; -.
DR   PhylomeDB; P52746; -.
DR   TreeFam; TF327469; -.
DR   ChiTaRS; ZNF142; human.
DR   GenomeRNAi; 7701; -.
DR   PRO; PR:P52746; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115568; -.
DR   CleanEx; HS_ZNF142; -.
DR   ExpressionAtlas; P52746; baseline and differential.
DR   Genevisible; P52746; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 5.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00355; ZnF_C2H2; 36.
DR   SUPFAM; SSF57667; SSF57667; 12.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Isopeptide bond; Metal-binding;
KW   Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1   1687       Zinc finger protein 142.
FT                                /FTId=PRO_0000047425.
FT   ZN_FING     163    185       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     219    242       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     253    275       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     286    311       C2H2-type 4; atypical.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   ZN_FING     316    340       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     343    366       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     372    395       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     401    423       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     429    451       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     457    479       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     485    507       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     512    536       C2H2-type 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     544    567       C2H2-type 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     573    596       C2H2-type 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1135   1158       C2H2-type 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1171   1194       C2H2-type 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1200   1222       C2H2-type 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1228   1251       C2H2-type 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1257   1280       C2H2-type 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1286   1309       C2H2-type 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1328   1351       C2H2-type 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1354   1377       C2H2-type 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1380   1403       C2H2-type 23. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1424   1446       C2H2-type 24. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1452   1474       C2H2-type 25. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1480   1502       C2H2-type 26. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1508   1530       C2H2-type 27. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1536   1559       C2H2-type 28. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1565   1587       C2H2-type 29. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1593   1615       C2H2-type 30. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING    1621   1643       C2H2-type 31. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   MOD_RES     154    154       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
FT   CROSSLNK    594    594       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000244|PubMed:25218447}.
FT   VARIANT     751    751       S -> G (in dbSNP:rs3770214).
FT                                {ECO:0000269|PubMed:9039502}.
FT                                /FTId=VAR_047230.
FT   VARIANT     956    956       L -> H (in dbSNP:rs3770213).
FT                                /FTId=VAR_047231.
FT   VARIANT    1313   1313       A -> T (in dbSNP:rs3821033).
FT                                /FTId=VAR_047232.
FT   CONFLICT    460    463       TECG -> LKGS (in Ref. 2; AAC50265).
FT                                {ECO:0000305}.
FT   CONFLICT    541    541       A -> S (in Ref. 1; BAA13242).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT      1508   1535       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1452   1474       ismart:ZnF_C2H2 [T]
FT   MYHIT       457    484       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       163    190       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1104   1124       ismart:ZnF_C2H2 [T]
FT   MYHIT       401    428       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1286   1309       ismart:ZnF_C2H2 [T]
FT   MYHIT      1257   1280       ismart:ZnF_C2H2 [T]
FT   MYHIT      1621   1643       ismart:ZnF_C2H2 [T]
FT   MYHIT      1482   1502       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       372    395       ismart:ZnF_C2H2 [T]
FT   MYHIT       318    340       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1288   1309       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1173   1194       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       253    280       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1593   1620       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1510   1530       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1230   1251       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       457    479       ismart:ZnF_C2H2 [T]
FT   MYHIT       255    275       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1595   1615       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       345    366       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1228   1251       ismart:ZnF_C2H2 [T]
FT   MYHIT      1135   1158       ismart:ZnF_C2H2 [T]
FT   MYHIT       866    886       ismart:ZnF_C2H2 [T]
FT   MYHIT       401    423       ismart:ZnF_C2H2 [T]
FT   MYHIT       573    596       ismart:ZnF_C2H2 [T]
FT   MYHIT      1380   1403       ismart:ZnF_C2H2 [T]
FT   MYHIT       163    185       ismart:ZnF_C2H2 [T]
FT   MYHIT      1200   1222       ismart:ZnF_C2H2 [T]
FT   MYHIT      1228   1256       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       431    451       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1286   1314       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1565   1592       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1356   1377       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1480   1502       ismart:ZnF_C2H2 [T]
FT   MYHIT      1328   1351       ismart:ZnF_C2H2 [T]
FT   MYHIT       286    311       ismart:ZnF_C2H2 [T]
FT   MYHIT       485    507       ismart:ZnF_C2H2 [T]
FT   MYHIT       836    858       ismart:ZnF_C2H2 [T]
FT   MYHIT      1536   1564       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       253    275       ismart:ZnF_C2H2 [T]
FT   MYHIT       191    218       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       343    371       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       429    456       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1354   1377       ismart:ZnF_C2H2 [T]
FT   MYHIT      1426   1446       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1171   1194       ismart:ZnF_C2H2 [T]
FT   MYHIT       514    536       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1354   1382       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT      1171   1199       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       191    211       ismart:ZnF_C2H2 [T]
FT   MYHIT      1452   1479       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       544    567       ismart:ZnF_C2H2 [T]
FT   MYHIT      1508   1530       ismart:ZnF_C2H2 [T]
FT   MYHIT      1593   1615       ismart:ZnF_C2H2 [T]
FT   MYHIT       316    340       ismart:ZnF_C2H2 [T]
FT   MYHIT      1567   1587       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1424   1446       ismart:ZnF_C2H2 [T]
FT   MYHIT       485    512       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       165    185       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       487    507       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT      1565   1587       ismart:ZnF_C2H2 [T]
FT   MYHIT       343    366       ismart:ZnF_C2H2 [T]
FT   MYHIT       512    535       ismart:ZnF_C2H2 [T]
FT   MYHIT      1480   1507       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       429    451       ismart:ZnF_C2H2 [T]
FT   MYHIT       219    242       ismart:ZnF_C2H2 [T]
FT   MYHIT      1026   1046       ismart:ZnF_C2H2 [T]
FT   MYHIT      1536   1559       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   1687 AA;  187880 MW;  91143EAF2481B6B3 CRC64;
     MTDPLLDSQP ASSTGEMDGL CPELLLIPPP LSNRGILGPV QSPCPSRDPA PIPTEPGCLL
     VEATATEEGP GNMEIIVETV AGTLTPGAPG ETPAPKLPPG EREPSQEAGT PLPGQETAEE
     ENVEKEEKSD TQKDSQKAVD KGQGAQRLEG DVVSGTESLF KTHMCPECKR CFKKRTHLVE
     HLHLHFPDPS LQCPNCQKFF TSKSKLKTHL LRELGEKAHH CPLCHYSAVE RNALNRHMAS
     MHEDISNFYS DTYACPVCRE EFRLSQALKE HLKSHTAAAA AEPLPLRCFQ EGCSYAAPDR
     KAFIKHLKET HGVRAVECRH HSCPMLFATA EAMEAHHKSH YAFHCPHCDF ACSNKHLFRK
     HKKQGHPGSE ELRCTFCPFA TFNPVAYQDH VGKMHAHEKI HQCPECNFAT AHKRVLIRHM
     LLHTGEKPHK CELCDFTCRD VSYLSKHMLT HSNTKDYMCT ECGYVTKWKH YLRVHMRKHA
     GDLRYQCNQC SYRCHRADQL SSHKLRHQGK SLMCEVCAFA CKRKYELQKH MASQHHPGTP
     APLYPCHYCS YQSRHKQAVL SHENCKHTRL REFHCALCDY RTFSNTTLLF HKRKAHGYVP
     GDQAWQLRYA SQEPEGAMQG PTPPPDSEPS NQLSARPEGP GHEPGTVVDP SLDQALPEMS
     EEVNTGRQEG SEAPHGGDLG GSPSPAEVEE GSCTLHLEAL GVELESVTEP PLEEVTETAP
     MEFRPLGLEG PDGLEGPELS SFEGIGTSDL SAEENPLLEK PVSEPSTNPP SLEEAPNNWV
     GTFKTTPPAE TAPLPPLPES ESLLKALRRQ DKEQAEALVL EGRVQMVVIQ GEGRAFRCPH
     CPFITRREKA LNLHSRTGCQ GRREPLLCPE CGASFKQQRG LSTHLLKKCP VLLRKNKGLP
     RPDSPIPLQP VLPGTQASED TESGKPPPAS QEAELLLPKD APLELPREPE ETEEPLATVS
     GSPVPPAGNS LPTEAPKKHC FDPVPPAGNS SPTEAPKKHH LDPVPPAGNS SPTEALKKHR
     FEQGKFHCNS CPFLCSRLSS ITSHVAEGCR GGRGGGGKRG TPQTQPDVSP LSNGDSAPPK
     NGSTESSSGD GDTVLVQKQK GARFSCPTCP FSCQQERALR THQIRGCPLE ESGELHCSLC
     PFTAPAATAL RLHQKRRHPT AAPARGPRPH LQCGDCGFTC KQSRCMQQHR RLKHEGVKPH
     QCPFCDFSTT RRYRLEAHQS RHTGIGRIPC SSCPQTFGTN SKLRLHRLRV HDKTPTHFCP
     LCDYSGYLRH DITRHVNSCH QGTPAFACSQ CEAQFSSETA LKQHALRRHP EPAQPAPGSP
     AETTEGPLHC SRCGLLCPSP ASLRGHTRKQ HPRLECGACQ EAFPSRLALD EHRRQQHFSH
     RCQLCDFAAR ERVGLVKHYL EQHEETSAAV AASDGDGDAG QPPLHCPFCD FTCRHQLVLD
     HHVKGHGGTR LYKCTDCAYS TKNRQKITWH SRIHTGEKPY HCHLCPYACA DPSRLKYHMR
     IHKEERKYLC PECGYKCKWV NQLKYHMTKH TGLKPYQCPE CEYCTNRADA LRVHQETRHR
     EARAFMCEQC GKAFKTRFLL RTHLRKHSEA KPYVCNVCHR AFRWAAGLRH HALTHTDRHP
     FFCRLCNYKA KQKFQVVKHV RRHHPDQADP NQGVGKDPTT PTVHLHDVQL EDPSPPAPAA
     PHTGPEG
//