ID ZF64A_HUMAN Reviewed; 681 AA.
AC Q9NPA5; Q9NTS7; Q9NVH4;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 3.
DT 10-MAY-2017, entry version 153.
DE RecName: Full=Zinc finger protein 64 homolog, isoforms 1 and 2;
DE Short=Zfp-64;
DE AltName: Full=Zinc finger protein 338;
GN Name=ZFP64; Synonyms=ZNF338;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ASN-451.
RC TISSUE=Neuron;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP ASN-451.
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5]
RP STRUCTURE BY NMR OF 339-397, AND ZINC-BINDING SITES.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the C2H2 type zinc-binding domain of human zinc
RT finger protein 64, isoforms 1 and 2.";
RL Submitted (MAY-2005) to the PDB data bank.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8WTP8:AEN; NbExp=3; IntAct=EBI-711679, EBI-8637627;
CC Q86V42:FAM124A; NbExp=3; IntAct=EBI-711679, EBI-744506;
CC Q14192:FHL2; NbExp=3; IntAct=EBI-711679, EBI-701903;
CC V9HWH0:HEL164; NbExp=3; IntAct=EBI-711679, EBI-10330301;
CC Q8WV44:TRIM41; NbExp=3; IntAct=EBI-711679, EBI-725997;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q9NPA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NPA5-2; Sequence=VSP_007284;
CC Name=3;
CC IsoId=Q9NTW7-1; Sequence=External;
CC Name=4; Synonyms=ZNF338;
CC IsoId=Q9NTW7-2; Sequence=External;
CC Name=5;
CC IsoId=Q9NTW7-3; Sequence=External;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK001596; BAA91777.1; -; mRNA.
DR EMBL; AK001744; BAA91876.1; -; mRNA.
DR EMBL; AL121771; CAB90276.1; -; Genomic_DNA.
DR EMBL; AL121771; CAB90277.1; -; Genomic_DNA.
DR EMBL; BC012759; AAH12759.1; -; mRNA.
DR EMBL; BC041622; AAH41622.1; -; mRNA.
DR CCDS; CCDS13440.1; -. [Q9NPA5-1]
DR CCDS; CCDS13441.1; -. [Q9NPA5-2]
DR RefSeq; NP_060667.2; NM_018197.2. [Q9NPA5-1]
DR RefSeq; NP_071371.3; NM_022088.4. [Q9NPA5-2]
DR RefSeq; NP_955458.1; NM_199426.1.
DR RefSeq; NP_955459.2; NM_199427.2.
DR UniGene; Hs.473082; -.
DR PDB; 1X5W; NMR; -; A=341-397.
DR PDB; 2DMD; NMR; -; A=174-256.
DR PDBsum; 1X5W; -.
DR PDBsum; 2DMD; -.
DR ProteinModelPortal; Q9NPA5; -.
DR SMR; Q9NPA5; -.
DR BioGrid; 120853; 27.
DR IntAct; Q9NPA5; 13.
DR STRING; 9606.ENSP00000216923; -.
DR iPTMnet; Q9NPA5; -.
DR PhosphoSitePlus; Q9NPA5; -.
DR BioMuta; SALL4; -.
DR DMDM; 116242854; -.
DR EPD; Q9NPA5; -.
DR PaxDb; Q9NPA5; -.
DR PeptideAtlas; Q9NPA5; -.
DR PRIDE; Q9NPA5; -.
DR DNASU; 55734; -.
DR Ensembl; ENST00000216923; ENSP00000216923; ENSG00000020256. [Q9NPA5-1]
DR Ensembl; ENST00000346617; ENSP00000344615; ENSG00000020256. [Q9NPA5-2]
DR GeneID; 55734; -.
DR KEGG; hsa:55734; -.
DR UCSC; uc002xwl.4; human. [Q9NPA5-1]
DR CTD; 55734; -.
DR DisGeNET; 55734; -.
DR GeneCards; ZFP64; -.
DR HGNC; HGNC:15940; ZFP64.
DR HPA; HPA035112; -.
DR HPA; HPA058387; -.
DR neXtProt; NX_Q9NPA5; -.
DR OpenTargets; ENSG00000020256; -.
DR PharmGKB; PA38060; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000063079; -.
DR HOGENOM; HOG000230887; -.
DR HOVERGEN; HBG056373; -.
DR InParanoid; Q9NPA5; -.
DR OrthoDB; EOG091G0SH1; -.
DR PhylomeDB; Q9NPA5; -.
DR TreeFam; TF333046; -.
DR EvolutionaryTrace; Q9NPA5; -.
DR GeneWiki; ZFP64; -.
DR GenomeRNAi; 55734; -.
DR Proteomes; UP000005640; Chromosome 20.
DR Bgee; ENSG00000020256; -.
DR CleanEx; HS_ZFP64; -.
DR ExpressionAtlas; Q9NPA5; baseline and differential.
DR Genevisible; Q9NPA5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; DNA-binding;
KW Metal-binding; Nucleus; Phosphoprotein; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 681 Zinc finger protein 64 homolog, isoforms
FT 1 and 2.
FT /FTId=PRO_0000047307.
FT ZN_FING 175 197 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 203 225 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 231 253 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 259 281 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 287 310 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 315 337 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 343 365 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 371 394 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 425 447 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT METAL 345 345 Zinc 1.
FT METAL 348 348 Zinc 1.
FT METAL 361 361 Zinc 1.
FT METAL 365 365 Zinc 1.
FT METAL 373 373 Zinc 2.
FT METAL 376 376 Zinc 2.
FT METAL 389 389 Zinc 2.
FT METAL 394 394 Zinc 2.
FT MOD_RES 547 547 Phosphoserine.
FT {ECO:0000244|PubMed:23186163}.
FT VAR_SEQ 96 149 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_007284.
FT VARIANT 68 68 Q -> P (in dbSNP:rs7353222).
FT /FTId=VAR_028019.
FT VARIANT 139 139 P -> L (in dbSNP:rs6021773).
FT /FTId=VAR_028020.
FT VARIANT 425 425 F -> Y (in dbSNP:rs16996517).
FT /FTId=VAR_028021.
FT VARIANT 451 451 S -> N (in dbSNP:rs3746414).
FT {ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_028022.
FT TURN 178 180 {ECO:0000244|PDB:2DMD}.
FT HELIX 187 193 {ECO:0000244|PDB:2DMD}.
FT HELIX 194 196 {ECO:0000244|PDB:2DMD}.
FT STRAND 202 204 {ECO:0000244|PDB:2DMD}.
FT STRAND 206 208 {ECO:0000244|PDB:2DMD}.
FT STRAND 211 214 {ECO:0000244|PDB:2DMD}.
FT HELIX 215 224 {ECO:0000244|PDB:2DMD}.
FT STRAND 234 237 {ECO:0000244|PDB:2DMD}.
FT STRAND 239 242 {ECO:0000244|PDB:2DMD}.
FT HELIX 243 250 {ECO:0000244|PDB:2DMD}.
FT STRAND 342 344 {ECO:0000244|PDB:1X5W}.
FT STRAND 346 349 {ECO:0000244|PDB:1X5W}.
FT STRAND 351 354 {ECO:0000244|PDB:1X5W}.
FT HELIX 355 362 {ECO:0000244|PDB:1X5W}.
FT HELIX 363 365 {ECO:0000244|PDB:1X5W}.
FT STRAND 370 372 {ECO:0000244|PDB:1X5W}.
FT STRAND 374 377 {ECO:0000244|PDB:1X5W}.
FT STRAND 379 382 {ECO:0000244|PDB:1X5W}.
FT HELIX 383 394 {ECO:0000244|PDB:1X5W}.
FT STRAND 395 397 {ECO:0000244|PDB:1X5W}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 259 281 ismart:ZnF_C2H2 [T]
FT MYHIT 427 447 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 343 370 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 203 225 ismart:ZnF_C2H2 [T]
FT MYHIT 175 197 ismart:ZnF_C2H2 [T]
FT MYHIT 203 230 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 144 169 ismart:ZnF_C2H2 [T]
FT MYHIT 315 342 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 343 365 ismart:ZnF_C2H2 [T]
FT MYHIT 371 394 ismart:ZnF_C2H2 [T]
FT MYHIT 175 202 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 425 447 ismart:ZnF_C2H2 [T]
FT MYHIT 287 310 ismart:ZnF_C2H2 [T]
FT MYHIT 259 286 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 425 452 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 177 197 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 371 394 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 261 281 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 231 253 ismart:ZnF_C2H2 [T]
FT MYHIT 289 310 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 287 315 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 315 337 ismart:ZnF_C2H2 [T]
FT MYHIT 231 258 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 345 365 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 31 51 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 681 AA; 74644 MW; 949C2DB54BB97E2E CRC64;
MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK QSGCQLTGTS
AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE FVFEHGYQTY LPTESNENQT
ATVISLPAKS RTKKPTTPPA QKRLNCCYPG CQFKTAYGMK DMERHLKIHT GDKPHKCEVC
GKCFSRKDKL KTHMRCHTGV KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS
RNSSQLTVHL RSHTGDAPFQ CWLCSAKFKI SSDLKRHMRV HSGEKPFKCE FCNVRCTMKG
NLKSHIRIKH SGNNFKCPHC DFLGDSKATL RKHSRVHQSE HPEKCSECSY SCSSKAALRI
HERIHCTDRP FKCNYCSFDT KQPSNLSKHM KKFHGDMVKT EALERKDTGR QSSRQVAKLD
AKKSFHCDIC DASFMREDSL RSHKRQHSEY SESKNSDVTV LQFQIDPSKQ PATPLTVGHL
QVPLQPSQVP QFSEGRVKII VGHQVPQANT IVQAAAAAVN IVPPALVAQN PEELPGNSRL
QILRQVSLIA PPQSSRCPSE AGAMTQPAVL LTTHEQTDGA TLHQTLIPTA SGGPQEGSGN
QTFITSSGIT CTDFEGLNAL IQEGTAEVTV VSDGGQNIAV ATTAPPVFSS SSQQELPKQT
YSIIQGAAHP ALLCPADSIP D
//
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