ID ZDHC4_HUMAN Reviewed; 344 AA.
AC Q9NPG8; A4D2N9; Q53EV7; Q6FIB5; Q9H0R9;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 15-MAR-2017, entry version 130.
DE RecName: Full=Probable palmitoyltransferase ZDHHC4;
DE EC=2.3.1.225;
DE AltName: Full=Zinc finger DHHC domain-containing protein 4;
DE Short=DHHC-4;
DE AltName: Full=Zinc finger protein 374;
GN Name=ZDHHC4; Synonyms=ZNF374; ORFNames=DC1, UNQ5787/PRO19576;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.;
RT "Novel genes expressed in human dendritic cells.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-53.
RC TISSUE=Testis;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] SER-104.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- CATALYTIC ACTIVITY: Palmitoyl-CoA + [protein]-L-cysteine =
CC [protein]-S-palmitoyl-L-cysteine + CoA.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase
CC activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000305}.
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DR EMBL; AF201931; AAF86867.1; -; mRNA.
DR EMBL; AL136674; CAB66609.1; -; mRNA.
DR EMBL; AY359090; AAQ89448.1; -; mRNA.
DR EMBL; CR533511; CAG38542.1; -; mRNA.
DR EMBL; AK001341; BAA91636.1; -; mRNA.
DR EMBL; AK223532; BAD97252.1; -; mRNA.
DR EMBL; AC079742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236963; EAL23725.1; -; Genomic_DNA.
DR EMBL; CH878731; EAW55023.1; -; Genomic_DNA.
DR EMBL; BC001239; AAH01239.1; -; mRNA.
DR CCDS; CCDS5352.1; -.
DR RefSeq; NP_001127859.1; NM_001134387.1.
DR RefSeq; NP_001127860.1; NM_001134388.1.
DR RefSeq; NP_001127861.1; NM_001134389.1.
DR RefSeq; NP_060576.1; NM_018106.3.
DR RefSeq; XP_005249850.1; XM_005249793.2.
DR RefSeq; XP_005249851.1; XM_005249794.3.
DR RefSeq; XP_005249852.1; XM_005249795.2.
DR RefSeq; XP_005249853.1; XM_005249796.3.
DR UniGene; Hs.5268; -.
DR ProteinModelPortal; Q9NPG8; -.
DR MINT; MINT-1208911; -.
DR STRING; 9606.ENSP00000337475; -.
DR iPTMnet; Q9NPG8; -.
DR PhosphoSitePlus; Q9NPG8; -.
DR BioMuta; ZDHHC4; -.
DR DMDM; 28202108; -.
DR EPD; Q9NPG8; -.
DR MaxQB; Q9NPG8; -.
DR PaxDb; Q9NPG8; -.
DR PeptideAtlas; Q9NPG8; -.
DR PRIDE; Q9NPG8; -.
DR DNASU; 55146; -.
DR Ensembl; ENST00000335965; ENSP00000337475; ENSG00000136247.
DR Ensembl; ENST00000396706; ENSP00000379934; ENSG00000136247.
DR Ensembl; ENST00000396707; ENSP00000379935; ENSG00000136247.
DR Ensembl; ENST00000396709; ENSP00000379937; ENSG00000136247.
DR Ensembl; ENST00000396713; ENSP00000379941; ENSG00000136247.
DR Ensembl; ENST00000405731; ENSP00000385027; ENSG00000136247.
DR GeneID; 55146; -.
DR KEGG; hsa:55146; -.
DR UCSC; uc003sqh.4; human.
DR CTD; 55146; -.
DR GeneCards; ZDHHC4; -.
DR HGNC; HGNC:18471; ZDHHC4.
DR HPA; HPA032124; -.
DR HPA; HPA064358; -.
DR neXtProt; NX_Q9NPG8; -.
DR OpenTargets; ENSG00000136247; -.
DR PharmGKB; PA38337; -.
DR eggNOG; KOG1312; Eukaryota.
DR eggNOG; COG5273; LUCA.
DR GeneTree; ENSGT00870000136460; -.
DR HOGENOM; HOG000253024; -.
DR HOVERGEN; HBG054775; -.
DR InParanoid; Q9NPG8; -.
DR KO; K20003; -.
DR OMA; GAWNIRY; -.
DR OrthoDB; EOG091G0BJJ; -.
DR PhylomeDB; Q9NPG8; -.
DR TreeFam; TF330931; -.
DR BRENDA; 2.3.1.225; 2681.
DR ChiTaRS; ZDHHC4; human.
DR GeneWiki; ZDHHC4; -.
DR GenomeRNAi; 55146; -.
DR PRO; PR:Q9NPG8; -.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000136247; -.
DR CleanEx; HS_ZDHHC4; -.
DR ExpressionAtlas; Q9NPG8; baseline and differential.
DR Genevisible; Q9NPG8; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR Pfam; PF01529; zf-DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Complete proteome; Lipoprotein; Membrane; Palmitate;
KW Polymorphism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 344 Probable palmitoyltransferase ZDHHC4.
FT /FTId=PRO_0000212865.
FT TRANSMEM 3 23 Helical. {ECO:0000255}.
FT TRANSMEM 68 88 Helical. {ECO:0000255}.
FT TRANSMEM 100 120 Helical. {ECO:0000255}.
FT TRANSMEM 193 213 Helical. {ECO:0000255}.
FT TRANSMEM 256 276 Helical. {ECO:0000255}.
FT DOMAIN 149 199 DHHC. {ECO:0000255|PROSITE-
FT ProRule:PRU00067}.
FT ACT_SITE 179 179 S-palmitoyl cysteine intermediate.
FT {ECO:0000250}.
FT VARIANT 53 53 V -> M (in dbSNP:rs11559146).
FT {ECO:0000269|Ref.6}.
FT /FTId=VAR_023832.
FT VARIANT 104 104 P -> S (in a breast cancer sample;
FT somatic mutation).
FT {ECO:0000269|PubMed:16959974}.
FT /FTId=VAR_036260.
FT CONFLICT 33 33 L -> P (in Ref. 6; BAD97252).
FT {ECO:0000305}.
FT CONFLICT 244 244 F -> I (in Ref. 2; CAB66609 and 4;
FT CAG38542). {ECO:0000305}.
FT CONFLICT 276 276 F -> S (in Ref. 2; CAB66609 and 4;
FT CAG38542). {ECO:0000305}.
FT CONFLICT 294 294 D -> V (in Ref. 2; CAB66609 and 4;
FT CAG38542). {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 150 292 ipfam:DHHC [T]
SQ SEQUENCE 344 AA; 39787 MW; 3D2CF22B14036908 CRC64;
MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ RAVHGLLHYL
FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY LLLPYLLLGV NLFFFTLTCG
TNPGIITKAN ELLFLHVYEF DEVMFPKNVR CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV
WVNNCIGAWN IRYFLIYVLT LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM
DTVFLIQYLF LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE
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