ID ZBT45_MOUSE Reviewed; 520 AA.
AC Q52KG4; Q3TLP9;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 10-MAY-2017, entry version 118.
DE RecName: Full=Zinc finger and BTB domain-containing protein 45 {ECO:0000303|PubMed:21131782};
DE AltName: Full=Zinc finger protein 499 {ECO:0000305};
GN Name=Zbtb45 {ECO:0000303|PubMed:21131782,
GN ECO:0000312|MGI:MGI:2685003};
GN Synonyms=Gm157 {ECO:0000312|MGI:MGI:2685003},
GN Zfp499 {ECO:0000312|MGI:MGI:2685003};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAH94359.1};
RN [1] {ECO:0000312|EMBL:BAE38743.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland {ECO:0000312|EMBL:BAE38743.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:EDL38083.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAH94359.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH94359.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAH94359.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=21131782; DOI=10.4161/cc.9.24.14154;
RA Soedersten E., Lilja T., Hermanson O.;
RT "The novel BTB/POZ and zinc finger factor Zbtb45 is essential for
RT proper glial differentiation of neural and oligodendrocyte progenitor
RT cells.";
RL Cell Cycle 9:4866-4875(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation
CC (Probable). In the central nervous system, may play a role in
CC glial cell differentiation (PubMed:21131782).
CC {ECO:0000269|PubMed:21131782, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Detected in embryonic forebrain at stages
CC E12.5 and E14.5 where it is ubiquitously expressed.
CC {ECO:0000269|PubMed:21131782}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK166382; BAE38743.1; -; mRNA.
DR EMBL; AC121301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466634; EDL38083.1; -; Genomic_DNA.
DR EMBL; CH466634; EDL38084.1; -; Genomic_DNA.
DR EMBL; BC094359; AAH94359.1; -; mRNA.
DR RefSeq; NP_001019870.1; NM_001024699.1.
DR RefSeq; XP_006539865.1; XM_006539802.1.
DR RefSeq; XP_006539866.1; XM_006539803.1.
DR RefSeq; XP_006539867.1; XM_006539804.2.
DR UniGene; Mm.279272; -.
DR SMR; Q52KG4; -.
DR STRING; 10090.ENSMUSP00000056086; -.
DR MaxQB; Q52KG4; -.
DR PaxDb; Q3TLP9; -.
DR PeptideAtlas; Q3TLP9; -.
DR Ensembl; ENSMUST00000051390; ENSMUSP00000056086; ENSMUSG00000049600.
DR Ensembl; ENSMUST00000172240; ENSMUSP00000130439; ENSMUSG00000049600.
DR Ensembl; ENSMUST00000210282; ENSMUSP00000147298; ENSMUSG00000049600.
DR GeneID; 232879; -.
DR KEGG; mmu:232879; -.
DR UCSC; uc009fez.1; mouse.
DR CTD; 84878; -.
DR MGI; MGI:2685003; Zbtb45.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119063; -.
DR HOGENOM; HOG000136747; -.
DR HOVERGEN; HBG060183; -.
DR KO; K10516; -.
DR OMA; APPDCVL; -.
DR OrthoDB; EOG091G0EMJ; -.
DR TreeFam; TF335684; -.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000049600; -.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 520 Zinc finger and BTB domain-containing
FT protein 45.
FT /FTId=PRO_0000439879.
FT DOMAIN 33 96 BTB. {ECO:0000255|PROSITE-
FT ProRule:PRU00037}.
FT ZN_FING 412 434 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 440 462 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 468 490 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 495 517 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT COMPBIAS 128 197 Pro-rich. {ECO:0000255|PROSITE-
FT ProRule:PRU00015}.
FT COMPBIAS 302 373 Pro-rich. {ECO:0000255|PROSITE-
FT ProRule:PRU00015}.
FT CONFLICT 304 304 S -> G (in Ref. 1; BAE38743).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 414 434 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 412 439 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 33 126 ismart:BTB [T]
FT MYHIT 495 520 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 468 495 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 23 122 ipfam:BTB [T]
FT MYHIT 440 467 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 470 490 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 442 462 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 440 462 ismart:ZnF_C2H2 [T]
FT MYHIT 33 96 iprf:BTB [T]
FT MYHIT 468 490 ismart:ZnF_C2H2 [T]
FT MYHIT 495 517 ismart:ZnF_C2H2 [T]
FT MYHIT 497 517 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 412 434 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 520 AA; 55012 MW; 3B239179EE6E92D3 CRC64;
MAATEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV LAAGSPFFQD
KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL QVLTAASVLR IQTVIDECTQ
IIARARVPNT PAPAPLPPPV PPPLAPAQLR HRLRHLLAAR PPGHPNAAHS RKQRQPARLQ
LPAPPAPIKA EGPDAEPALT AAPEDRGEED DDEETDEETD AEEGEGGGGG PGEGQAPPAF
PDCAGGFLTT AADSAREDPP ASTGITDYGG AGRDFLRGTG VTEDVFPDSY VSAWHEESSG
GPESCPVETS APPDCALAGP RPTGVKTPGP PVALFPFHLG APGPPAPTPP TPSGPAPAPP
PTFYPTLQPD AAPSAQLGET QAVPAAPAAQ ATAISGTPVR APGGQGAEQP AYECSHCRKT
FSSRKNYTKH MFIHSGEKPH QCAVCWRSFS LRDYLLKHMV THTGVRAFQC AVCAKRFTQK
SSLNVHMRTH RPERAPCPAC GKVFSHRALL ERHLAAHPAP
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