ID ZBT45_HUMAN Reviewed; 511 AA.
AC Q96K62;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 10-MAY-2017, entry version 125.
DE RecName: Full=Zinc finger and BTB domain-containing protein 45;
DE AltName: Full=Zinc finger protein 499;
GN Name=ZBTB45; Synonyms=ZNF499;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation
CC (Probable). In the central nervous system, may play a role in
CC glial cell differentiation (By similarity).
CC {ECO:0000250|UniProtKB:Q52KG4, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK027392; BAB55079.1; -; mRNA.
DR EMBL; BC024738; AAH24738.1; -; mRNA.
DR CCDS; CCDS12984.1; -.
DR RefSeq; NP_001303907.1; NM_001316978.1.
DR RefSeq; NP_001303908.1; NM_001316979.1.
DR RefSeq; NP_001303909.1; NM_001316980.1.
DR RefSeq; NP_001303910.1; NM_001316981.1.
DR RefSeq; NP_001303911.1; NM_001316982.1.
DR RefSeq; NP_116181.1; NM_032792.3.
DR RefSeq; XP_006723508.1; XM_006723445.3.
DR UniGene; Hs.515662; -.
DR ProteinModelPortal; Q96K62; -.
DR SMR; Q96K62; -.
DR BioGrid; 124322; 1.
DR DIP; DIP-62048N; -.
DR IntAct; Q96K62; 4.
DR MINT; MINT-1418836; -.
DR STRING; 9606.ENSP00000346603; -.
DR iPTMnet; Q96K62; -.
DR PhosphoSitePlus; Q96K62; -.
DR BioMuta; ZBTB45; -.
DR DMDM; 45477325; -.
DR EPD; Q96K62; -.
DR PaxDb; Q96K62; -.
DR PeptideAtlas; Q96K62; -.
DR PRIDE; Q96K62; -.
DR DNASU; 84878; -.
DR Ensembl; ENST00000354590; ENSP00000346603; ENSG00000119574.
DR Ensembl; ENST00000594051; ENSP00000469089; ENSG00000119574.
DR Ensembl; ENST00000600990; ENSP00000473072; ENSG00000119574.
DR GeneID; 84878; -.
DR KEGG; hsa:84878; -.
DR UCSC; uc002qtd.3; human.
DR CTD; 84878; -.
DR GeneCards; ZBTB45; -.
DR HGNC; HGNC:23715; ZBTB45.
DR HPA; HPA035754; -.
DR neXtProt; NX_Q96K62; -.
DR OpenTargets; ENSG00000119574; -.
DR PharmGKB; PA162409464; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119063; -.
DR HOGENOM; HOG000136747; -.
DR HOVERGEN; HBG060183; -.
DR InParanoid; Q96K62; -.
DR KO; K10516; -.
DR OMA; APPDCVL; -.
DR OrthoDB; EOG091G0EMJ; -.
DR PhylomeDB; Q96K62; -.
DR TreeFam; TF335684; -.
DR ChiTaRS; ZBTB45; human.
DR GenomeRNAi; 84878; -.
DR PRO; PR:Q96K62; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000119574; -.
DR CleanEx; HS_ZBTB45; -.
DR ExpressionAtlas; Q96K62; baseline and differential.
DR Genevisible; Q96K62; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Neurogenesis; Nucleus;
KW Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 511 Zinc finger and BTB domain-containing
FT protein 45.
FT /FTId=PRO_0000047619.
FT DOMAIN 33 96 BTB. {ECO:0000255|PROSITE-
FT ProRule:PRU00037}.
FT ZN_FING 403 425 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 431 453 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 459 481 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 486 508 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT COMPBIAS 128 197 Pro-rich.
FT COMPBIAS 299 401 Pro-rich.
FT VARIANT 293 293 D -> E (in dbSNP:rs35430780).
FT /FTId=VAR_052924.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 403 430 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 23 122 ipfam:BTB [T]
FT MYHIT 459 481 ismart:ZnF_C2H2 [T]
FT MYHIT 459 486 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 433 453 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 405 425 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 33 126 ismart:BTB [T]
FT MYHIT 33 96 iprf:BTB [T]
FT MYHIT 488 508 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 431 453 ismart:ZnF_C2H2 [T]
FT MYHIT 486 511 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 461 481 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 403 425 ismart:ZnF_C2H2 [T]
FT MYHIT 431 458 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 486 508 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 511 AA; 54008 MW; 6E691746C51CB988 CRC64;
MAAAEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV LAAGSPFFQD
KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL QVLTAASVLR IQTVIDECTQ
IIARARAPGT SAPTPLPTPV PPPLAPAQLR HRLRHLLAAR PPGHPGAAHS RKQRQPARLQ
LPAPPTPAKA EGPDADPSLS AAPDDRGDED DEESDDETDG EDGEGGGPGE GQAPPSFPDC
AAGFLTAAAD SACEEPPAPT GLADYSGAGR DFLRGAGSAE DVFPDSYVST WHDEDGAVPE
GCPTETPVQP DCILSGSRPP GVKTPGPPVA LFPFHLGAPG PPAPPPSAPS GPAPAPPPAF
YPTLQPEAAP STQLGEVPAP SAAPTTAPSG TPARTPGAEP PTYECSHCRK TFSSRKNYTK
HMFIHSGEKP HQCAVCWRSF SLRDYLLKHM VTHTGVRAFQ CAVCAKRFTQ KSSLNVHMRT
HRPERAPCPA CGKVFSHRAL LERHLAAHPA P
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