ID ZBT22_HUMAN Reviewed; 634 AA.
AC O15209; B0V007; Q5HYV4; Q5STL0; Q5STR7; Q8WV82;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 10-MAY-2017, entry version 157.
DE RecName: Full=Zinc finger and BTB domain-containing protein 22;
DE AltName: Full=Protein BING1;
DE AltName: Full=Zinc finger and BTB domain-containing protein 22A;
DE AltName: Full=Zinc finger protein 297;
GN Name=ZBTB22; Synonyms=BING1, ZBTB22A, ZNF297;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9545376; DOI=10.1006/jmbi.1998.1637;
RA Herberg J.A., Beck S., Trowsdale J.;
RT "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a
RT dense cluster at the centromeric end of the MHC.";
RL J. Mol. Biol. 277:839-857(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-310.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310.
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC A8KA83:-; NbExp=3; IntAct=EBI-723574, EBI-10174961;
CC P51116:FXR2; NbExp=3; IntAct=EBI-723574, EBI-740459;
CC Q96EZ8:MCRS1; NbExp=5; IntAct=EBI-723574, EBI-348259;
CC Q6P2C6:MLLT6; NbExp=3; IntAct=EBI-723574, EBI-5773143;
CC Q13526:PIN1; NbExp=3; IntAct=EBI-723574, EBI-714158;
CC Q14498-3:RBM39; NbExp=3; IntAct=EBI-723574, EBI-6654703;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; Z97183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z97184; CAB09990.1; -; Genomic_DNA.
DR EMBL; AK315747; BAG38101.1; -; mRNA.
DR EMBL; AL662820; CAI18123.1; -; Genomic_DNA.
DR EMBL; AL662827; CAI17526.1; -; Genomic_DNA.
DR EMBL; BX248088; CAI41787.2; -; Genomic_DNA.
DR EMBL; CR759786; CAQ08263.1; -; Genomic_DNA.
DR EMBL; CR759817; CAQ08033.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03721.1; -; Genomic_DNA.
DR EMBL; BC018541; AAH18541.1; -; mRNA.
DR CCDS; CCDS4775.1; -.
DR RefSeq; NP_001138810.1; NM_001145338.1.
DR RefSeq; NP_005444.4; NM_005453.4.
DR UniGene; Hs.206770; -.
DR ProteinModelPortal; O15209; -.
DR SMR; O15209; -.
DR BioGrid; 114695; 10.
DR DIP; DIP-62047N; -.
DR IntAct; O15209; 16.
DR MINT; MINT-1402804; -.
DR STRING; 9606.ENSP00000404403; -.
DR iPTMnet; O15209; -.
DR PhosphoSitePlus; O15209; -.
DR BioMuta; ZBTB22; -.
DR MaxQB; O15209; -.
DR PaxDb; O15209; -.
DR PeptideAtlas; O15209; -.
DR PRIDE; O15209; -.
DR DNASU; 9278; -.
DR Ensembl; ENST00000383196; ENSP00000372683; ENSG00000206280.
DR Ensembl; ENST00000416097; ENSP00000393514; ENSG00000229253.
DR Ensembl; ENST00000418540; ENSP00000388191; ENSG00000227780.
DR Ensembl; ENST00000418724; ENSP00000404403; ENSG00000236104.
DR Ensembl; ENST00000431845; ENSP00000407545; ENSG00000236104.
DR Ensembl; ENST00000445320; ENSP00000396292; ENSG00000237056.
DR GeneID; 9278; -.
DR KEGG; hsa:9278; -.
DR UCSC; uc003oeb.4; human.
DR CTD; 9278; -.
DR DisGeNET; 9278; -.
DR GeneCards; ZBTB22; -.
DR HGNC; HGNC:13085; ZBTB22.
DR HPA; HPA043848; -.
DR MIM; 611439; gene.
DR neXtProt; NX_O15209; -.
DR OpenTargets; ENSG00000236104; -.
DR PharmGKB; PA37661; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119063; -.
DR HOGENOM; HOG000231975; -.
DR HOVERGEN; HBG056510; -.
DR InParanoid; O15209; -.
DR KO; K10502; -.
DR OMA; EDFPSAY; -.
DR OrthoDB; EOG09370O8X; -.
DR PhylomeDB; O15209; -.
DR ChiTaRS; ZBTB22; human.
DR GenomeRNAi; 9278; -.
DR PRO; PR:O15209; -.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000206280; -.
DR CleanEx; HS_ZBTB22; -.
DR ExpressionAtlas; O15209; baseline and differential.
DR Genevisible; O15209; HS.
DR GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ.
DR InterPro; IPR029833; ZBT22.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24414:SF46; PTHR24414:SF46; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Phosphoprotein; Polymorphism; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 634 Zinc finger and BTB domain-containing
FT protein 22.
FT /FTId=PRO_0000047517.
FT DOMAIN 57 121 BTB. {ECO:0000255|PROSITE-
FT ProRule:PRU00037}.
FT ZN_FING 486 507 C2H2-type 1; atypical.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 513 535 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 541 562 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT MOD_RES 202 202 Phosphoserine.
FT {ECO:0000244|PubMed:23186163}.
FT VARIANT 250 250 G -> A (in dbSNP:rs35663442).
FT /FTId=VAR_057457.
FT VARIANT 310 310 T -> A (in dbSNP:rs3130100).
FT {ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_022702.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 513 535 ismart:ZnF_C2H2 [T]
FT MYHIT 57 151 ismart:BTB [T]
FT MYHIT 513 540 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 486 512 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 541 562 ismart:ZnF_C2H2 [T]
FT MYHIT 515 535 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 47 149 ipfam:BTB [T]
FT MYHIT 486 507 ismart:ZnF_C2H2 [T]
FT MYHIT 57 121 iprf:BTB [T]
SQ SEQUENCE 634 AA; 65602 MW; 9CC1867213D6DEF7 CRC64;
MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS
IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA
AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTITT AAATSVTVPG AGVPSGSGGT
VAPATMGSAR SHASSRASEN QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP
VFPAPVVGSG GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV
KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG GPEATLSISD
VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG GPTPSSYAPS HPPRPLLPLD
MQGNQILVFP SSSSSSSSQA PGQPPGNQAE HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG
DGNKIFLCHC GKAFSHKSMR DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP
YECGVCAKKF MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG
DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN
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