Entry euk:YAOL_ARATH

ID   YAOL_ARATH              Reviewed;         479 AA.
AC   Q3MKM6; O49554;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   12-APR-2017, entry version 93.
DE   RecName: Full=U3 snoRNP-associated protein-like EMB2271 {ECO:0000305};
DE   AltName: Full=Protein EMBRYO DEFECTIVE 2271 {ECO:0000305};
DE   AltName: Full=Protein YAO-like {ECO:0000305};
GN   Name=EMB2271 {ECO:0000312|EMBL:AEE84406.1};
GN   OrderedLocusNames=At4g21130 {ECO:0000312|Araport:AT4G21130};
GN   ORFNames=F7J7.70 {ECO:0000312|EMBL:CAA17532.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=16054306; DOI=10.1016/j.gene.2005.05.022;
RA   Urbanek P., Paces J., Paces V.;
RT   "An approach towards experimental cDNA sequence determination of
RT   predicted genes: an example from Arabidopsis U3-55k homologues.";
RL   Gene 358:67-72(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
RA   Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
RA   Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
RA   Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
RA   Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
RA   Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
RA   Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
RA   Langham S.-A., McCullagh B., Bilham L., Robben J.,
RA   van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
RA   Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA   Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
RA   Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
RA   De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
RA   van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
RA   Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
RA   Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
RA   Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
RA   Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA   Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
RA   Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
RA   Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
RA   Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
RA   Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
RA   Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
RA   Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
RA   Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
RA   Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
RA   Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
RA   Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
RA   Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
RA   Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
RA   Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
RA   Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
RA   Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
RA   Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
RA   Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
RA   Chen E., Marra M.A., Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Portal (Araport);
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=20699009; DOI=10.1186/1471-2229-10-169;
RA   Li H.J., Liu N.Y., Shi D.Q., Liu J., Yang W.C.;
RT   "YAO is a nucleolar WD40-repeat protein critical for embryogenesis and
RT   gametogenesis in Arabidopsis.";
RL   BMC Plant Biol. 10:169-169(2010).
CC   -!- FUNCTION: Component of a nucleolar small nuclear ribonucleoprotein
CC       particle (snoRNP) thought to participate in the processing and
CC       modification of pre-ribosomal RNA (By similarity). Essential for
CC       embryogenesis (By similarity). May function during late
CC       embryogenesis (PubMed:20699009). {ECO:0000250|UniProtKB:O43818,
CC       ECO:0000250|UniProtKB:Q9M0V4, ECO:0000305|PubMed:20699009}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9M0V4}.
CC   -!- DISRUPTION PHENOTYPE: Embryonic lethality.
CC       {ECO:0000305|PubMed:20699009}.
CC   -!- SIMILARITY: Belongs to the WD repeat RRP9 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA17532.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB79113.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY874865; AAY21208.1; -; mRNA.
DR   EMBL; AL021960; CAA17532.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161554; CAB79113.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE84406.1; -; Genomic_DNA.
DR   PIR; T04944; T04944.
DR   RefSeq; NP_193845.2; NM_118232.2.
DR   UniGene; At.54451; -.
DR   ProteinModelPortal; Q3MKM6; -.
DR   SMR; Q3MKM6; -.
DR   STRING; 3702.AT4G21130.1; -.
DR   PaxDb; Q3MKM6; -.
DR   PRIDE; Q3MKM6; -.
DR   EnsemblPlants; AT4G21130.1; AT4G21130.1; AT4G21130.
DR   GeneID; 827861; -.
DR   Gramene; AT4G21130.1; AT4G21130.1; AT4G21130.
DR   KEGG; ath:AT4G21130; -.
DR   Araport; AT4G21130; -.
DR   TAIR; locus:2127408; AT4G21130.
DR   eggNOG; KOG0299; Eukaryota.
DR   eggNOG; ENOG410XP9U; LUCA.
DR   HOGENOM; HOG000188732; -.
DR   InParanoid; Q3MKM6; -.
DR   KO; K14793; -.
DR   OMA; AITGLDC; -.
DR   OrthoDB; EOG09360EVF; -.
DR   PhylomeDB; Q3MKM6; -.
DR   Reactome; R-ATH-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q3MKM6; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   Genevisible; Q3MKM6; AT.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISS:TAIR.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Nucleus; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; rRNA processing; WD repeat.
FT   CHAIN         1    479       U3 snoRNP-associated protein-like
FT                                EMB2271.
FT                                /FTId=PRO_0000433091.
FT   REPEAT      143    182       WD 1. {ECO:0000255}.
FT   REPEAT      204    243       WD 2. {ECO:0000255}.
FT   REPEAT      246    285       WD 3. {ECO:0000255}.
FT   REPEAT      288    326       WD 4. {ECO:0000255}.
FT   REPEAT      328    366       WD 5. {ECO:0000255}.
FT   REPEAT      386    425       WD 6. {ECO:0000255}.
FT   REPEAT      431    471       WD 7. {ECO:0000255}.
FT   COMPBIAS     27     97       Glu-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00007}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       279    317       ismart:WD40 [T]
FT   MYHIT       202    243       iprf:WD_REPEATS_2 [T]
FT   MYHIT       367    416       ismart:WD40 [T]
FT   MYHIT       244    285       iprf:WD_REPEATS_2 [T]
FT   MYHIT       319    357       ismart:WD40 [T]
FT   MYHIT       141    182       iprf:WD_REPEATS_2 [T]
FT   MYHIT       221    235       ipat:WD_REPEATS_1 [T]
FT   MYHIT       210    234       ipfam:WD40 [T]
FT   MYHIT       237    276       ismart:WD40 [T]
FT   MYHIT       141    425       iprf:WD_REPEATS_REGION [T]
FT   MYHIT       239    276       ipfam:WD40 [T]
FT   MYHIT       195    234       ismart:WD40 [T]
FT   MYHIT       263    277       ipat:WD_REPEATS_1 [T]
FT   MYHIT       134    173       ismart:WD40 [T]
SQ   SEQUENCE   479 AA;  53582 MW;  5A3F4C14FF461B12 CRC64;
     MKLEKKKGIG AKRRGKKSSI DHDPFLEEET EKRRKFNYDD DDDIESVESE EEGKVGEEVE
     DEFAHETVGE KRKRLAEDTL NRIEEAKQRE HEEDNEEDDD FRDSLVAKTL MQEQLEKSGR
     VRRANALRVQ DLQSSDKFRV IVKHQHSVTG VALSDDDSRG FSVSKDGTIL HWDVSSGKSD
     EYKWPSDEVL KSHGLKFQES WYTRHNKQSL ALAVSSDGRY LATGGVDCHV HLWDIRTREH
     VQAFTGHCGI VSSLCFREGT AELFSGSYDG TLSIWNAEHR TYIESCFGHQ SELLSIDALG
     RERVLSVGRD RTMQLYKVPE STRLIYRASE SNFECCCFVN SDEFLSGSDN GSIALWSILK
     KKPVFIVNNA HHVIADHDSV NHNCTPACSW VSSVAVCRGS ELAASGAGNG CVRLWGVESG
     SSAIQPLYEL PLPGFVNSLA FAKSGRFLIA GVGQEPRLGR WGCLKSAQNG VAIHPLRLS
//