ID VA712_ARATH Reviewed; 219 AA.
AC Q9SIQ9;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 10-MAY-2017, entry version 114.
DE RecName: Full=Vesicle-associated membrane protein 712 {ECO:0000303|PubMed:11115874};
DE Short=AtVAMP712 {ECO:0000303|PubMed:11115874};
GN Name=VAMP712 {ECO:0000303|PubMed:11115874};
GN OrderedLocusNames=At2g25340 {ECO:0000312|Araport:AT2G25340};
GN ORFNames=T22F11.7 {ECO:0000312|EMBL:AAD23657.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
RA Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis
RT thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Portal (Araport);
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11115874; DOI=10.1104/pp.124.4.1558;
RA Sanderfoot A.A., Assaad F.F., Raikhel N.V.;
RT "The Arabidopsis genome. An abundance of soluble N-ethylmaleimide-
RT sensitive factor adaptor protein receptors.";
RL Plant Physiol. 124:1558-1569(2000).
RN [4]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=15342965; DOI=10.1247/csf.29.49;
RA Uemura T., Ueda T., Ohniwa R.L., Nakano A., Takeyasu K., Sato M.H.;
RT "Systematic analysis of SNARE molecules in Arabidopsis: dissection of
RT the post-Golgi network in plant cells.";
RL Cell Struct. Funct. 29:49-65(2004).
RN [5]
RP DOMAIN.
RX PubMed=15876431; DOI=10.1016/j.febslet.2005.04.022;
RA Uemura T., Sato M.H., Takeyasu K.;
RT "The longin domain regulates subcellular targeting of VAMP7 in
RT Arabidopsis thaliana.";
RL FEBS Lett. 579:2842-2846(2005).
CC -!- FUNCTION: Involved in the targeting and/or fusion of transport
CC vesicles to their target membrane. {ECO:0000305|PubMed:11115874}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane
CC {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane
CC protein {ECO:0000250|UniProtKB:Q12255}. Prevacuolar compartment
CC membrane {ECO:0000269|PubMed:15342965}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:Q12255}.
CC -!- TISSUE SPECIFICITY: Expressed in flowers, leaves, stems and roots.
CC {ECO:0000269|PubMed:15342965}.
CC -!- DOMAIN: The longin domain is critical for the vacuolar
CC localization. {ECO:0000269|PubMed:15876431}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; AC007070; AAD23657.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07690.1; -; Genomic_DNA.
DR PIR; C84647; C84647.
DR RefSeq; NP_180106.1; NM_128091.1.
DR UniGene; At.52906; -.
DR ProteinModelPortal; Q9SIQ9; -.
DR SMR; Q9SIQ9; -.
DR STRING; 3702.AT2G25340.1; -.
DR PaxDb; Q9SIQ9; -.
DR EnsemblPlants; AT2G25340.1; AT2G25340.1; AT2G25340.
DR GeneID; 817072; -.
DR Gramene; AT2G25340.1; AT2G25340.1; AT2G25340.
DR KEGG; ath:AT2G25340; -.
DR Araport; AT2G25340; -.
DR TAIR; locus:2059591; AT2G25340.
DR eggNOG; KOG0859; Eukaryota.
DR eggNOG; COG5143; LUCA.
DR HOGENOM; HOG000042711; -.
DR InParanoid; Q9SIQ9; -.
DR KO; K08515; -.
DR OMA; KKIQYAV; -.
DR OrthoDB; EOG09360NL1; -.
DR PhylomeDB; Q9SIQ9; -.
DR Reactome; R-ATH-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR PRO; PR:Q9SIQ9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIQ9; differential.
DR Genevisible; Q9SIQ9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; TAS:TAIR.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR011012; Longin-like_dom.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR001388; Synaptobrevin.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Vacuole.
FT INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:O49377}.
FT CHAIN 2 219 Vesicle-associated membrane protein 712.
FT /FTId=PRO_0000206751.
FT TOPO_DOM 2 189 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 190 210 Helical; Anchor for type IV membrane
FT protein. {ECO:0000255}.
FT TOPO_DOM 211 219 Vesicular. {ECO:0000255}.
FT DOMAIN 7 111 Longin. {ECO:0000255|PROSITE-
FT ProRule:PRU00231}.
FT DOMAIN 126 186 v-SNARE coiled-coil homology.
FT {ECO:0000255|PROSITE-ProRule:PRU00290}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 124 211 ipfam:Synaptobrevin [T]
FT MYHIT 29 108 ipfam:Longin [T]
FT MYHIT 7 111 iprf:LONGIN [T]
FT MYHIT 144 163 ipat:SYNAPTOBREVIN [T]
FT MYHIT 28 110 ismart:Longin [T]
FT MYHIT 126 186 iprf:V_SNARE [T]
SQ SEQUENCE 219 AA; 24966 MW; 7A63C85A140913B9 CRC64;
MSILYALVAR GTVVLAELST TSTNASTIAK QILEKIPGNG DSHVSYSQDR YVFHVKRTDG
LTVLCMADED AGRRIPFSFL EDIHQRFVRT YGRAIHSAQA YAMNDEFSRV LNQQIEYYSN
DPNADTISRI KGEMNQVRDV MIENIDNILD RGERLELLVD KTANMQGNTF RFRKQTRRFN
NTVWWRNCKL TLLLILVLLV IIYIGVAFAC HGPTLPSCV
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