ID U3JAA6_DANRE Unreviewed; 661 AA.
AC U3JAA6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 15-MAR-2017, entry version 19.
DE SubName: Full=Pim proto-oncogene, serine/threonine kinase,-related 134 {ECO:0000313|Ensembl:ENSDARP00000127171};
DE Flags: Fragment;
GN Name=pimr134 {ECO:0000313|Ensembl:ENSDARP00000127171,
GN ECO:0000313|ZFIN:ZDB-GENE-041014-80};
GN Synonyms=si:dkey-197d18.3 {ECO:0000313|ZFIN:ZDB-GENE-041014-80};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000127171, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000127171, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127171,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000127171}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127171};
RG Ensembl;
RL Submitted (SEP-2013) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000127171}.
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DR EMBL; BX284681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSDART00000145199; ENSDARP00000127171; ENSDARG00000094146.
DR ZFIN; ZDB-GENE-041014-80; pimr134.
DR GeneTree; ENSGT00760000119045; -.
DR OrthoDB; EOG091G0YCF; -.
DR Proteomes; UP000000437; Chromosome 20.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0046777; P:protein autophosphorylation; IBA:GO_Central.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 396 651 Protein kinase.
FT {ECO:0000259|PROSITE:PS50011}.
FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSDARP00000127171}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 524 536 ipat:PROTEIN_KINASE_ST [T]
FT MYHIT 396 651 ismart:S_TKc [T]
FT MYHIT 396 651 ipfam:Pkinase [T]
FT MYHIT 396 651 iprf:PROTEIN_KINASE_DOM [T]
FT MYHIT 402 425 ipat:PROTEIN_KINASE_ATP [T]
SQ SEQUENCE 661 AA; 72593 MW; FB6F12524B464050 CRC64;
XTEINPKMLF TVLGVIALFL RERNIKSTVS GQDESFDRQE EELVTVPSVA NSDGRQIGDW
CEESSLHLEE QINIQTEEPS LEEPVDGQSE EPSLVEPDSV HSEEPSLVEP DSVHSEEPSL
VEPDSVHGEE PSLVEPDSVH GEEPSLVEPD SVHGEELSLV EPVDGHSEDS ASSSSSDDVP
LNLFYAESSS SDDYPQEIYS AGFNCSSELT VSSYSSFFSA ESGCGDDAST DFLSAESGCG
DDASTVFLSA ESGCGDDPST EFLSAESGCG DDPPPNVVSA KPGCSHDDPP NVVSAKPGCS
HDDPPNVVSP KPGCSHDDPP NVVSAKPGCS HDDPPNVVSP KPSCSYNPSL NVVSAKLGCK
DVGKGATCQT KGAVPHQPKK QKDKDKHVIK INSKSYEIGA ELGKGSFGTV FAATRLQDGF
QVAVKIADFS VKRFIRVDDF DQPLPAEIAL HFLATKGPEV KELVQLLDWK VEANRYFMVL
ELPTPCVSVR EFLREHEDRI QEEVIRKIMY QATIAADTCC KRGVLHRDIK PGNLLINPQT
YEVKLIDFGC GELLTDSFYR KYRGTMKFSP PEFKRNGYYN GEPATVWSLG ILQFLLMLKI
YPGKHDIRRM KNKDFYQYGR SKECCDFISC CLQPLPSSRH TLNALLDHAW FKEENKKEEE
K
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