ID TRNH1_ARATH Reviewed; 266 AA.
AC P0DKI3; Q9ASX2; Q9LNW5;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 04-MAR-2015, sequence version 1.
DT 10-MAY-2017, entry version 20.
DE RecName: Full=Tropinone reductase homolog At1g07440 {ECO:0000305};
DE EC=1.1.1.- {ECO:0000305};
GN OrderedLocusNames=At1g07440 {ECO:0000312|Araport:AT1G07440};
GN ORFNames=F22G5.16, F22G5.20 {ECO:0000312|EMBL:AAF79553.1}, F22G5.39;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Portal (Araport);
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M.,
RA Thornton J.M., Adamski J., Oppermann U.;
RT "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT nomenclature initiative.";
RL Chem. Biol. Interact. 178:94-98(2009).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
RG Center for eukaryotic structural genomics (CESG);
RT "X-ray structure of putative tropinone reductase from Arabidopsis
RT thaliana At1g07440.";
RL Submitted (FEB-2005) to the PDB data bank.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=P0DKI3-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC (SDR) family. SDR65C subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79553.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g07440 and At1g07450.; Evidence={ECO:0000305};
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DR EMBL; AC022464; AAF79553.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28125.1; -; Genomic_DNA.
DR EMBL; AF361621; AAK32789.1; -; mRNA.
DR EMBL; AY055094; AAL05894.1; -; mRNA.
DR PIR; C86209; C86209.
DR RefSeq; NP_172224.1; NM_100618.5. [P0DKI3-1]
DR UniGene; At.16717; -.
DR PDB; 1XQ1; X-ray; 2.10 A; A=1-266.
DR PDB; 2Q45; X-ray; 2.10 A; A=1-266.
DR PDBsum; 1XQ1; -.
DR PDBsum; 2Q45; -.
DR ProteinModelPortal; P0DKI3; -.
DR SMR; P0DKI3; -.
DR STRING; 3702.AT1G07440.1; -.
DR PaxDb; P0DKI3; -.
DR EnsemblPlants; AT1G07440.1; AT1G07440.1; AT1G07440. [P0DKI3-1]
DR GeneID; 837256; -.
DR Gramene; AT1G07440.1; AT1G07440.1; AT1G07440.
DR KEGG; ath:AT1G07440; -.
DR Araport; AT1G07440; -.
DR eggNOG; KOG0725; Eukaryota.
DR eggNOG; COG1028; LUCA.
DR OMA; QHIPAGH; -.
DR OrthoDB; EOG09360JKH; -.
DR PhylomeDB; P0DKI3; -.
DR PRO; PR:P0DKI3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P0DKI3; baseline and differential.
DR Genevisible; P0DKI3; AT.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; NADP;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1 266 Tropinone reductase homolog At1g07440.
FT /FTId=PRO_0000054789.
FT NP_BIND 18 42 NADP. {ECO:0000250|UniProtKB:P50162}.
FT ACT_SITE 164 164 Proton acceptor. {ECO:0000255|PROSITE-
FT ProRule:PRU10001}.
FT BINDING 151 151 Substrate.
FT {ECO:0000250|UniProtKB:P50162}.
FT HELIX 8 10 {ECO:0000244|PDB:2Q45}.
FT STRAND 16 19 {ECO:0000244|PDB:1XQ1}.
FT TURN 20 23 {ECO:0000244|PDB:1XQ1}.
FT HELIX 25 36 {ECO:0000244|PDB:1XQ1}.
FT STRAND 40 46 {ECO:0000244|PDB:1XQ1}.
FT HELIX 48 60 {ECO:0000244|PDB:1XQ1}.
FT STRAND 65 69 {ECO:0000244|PDB:1XQ1}.
FT HELIX 75 89 {ECO:0000244|PDB:1XQ1}.
FT STRAND 94 99 {ECO:0000244|PDB:1XQ1}.
FT HELIX 113 141 {ECO:0000244|PDB:1XQ1}.
FT STRAND 145 149 {ECO:0000244|PDB:1XQ1}.
FT HELIX 163 182 {ECO:0000244|PDB:1XQ1}.
FT HELIX 183 185 {ECO:0000244|PDB:1XQ1}.
FT STRAND 188 193 {ECO:0000244|PDB:1XQ1}.
FT HELIX 226 229 {ECO:0000244|PDB:1XQ1}.
FT HELIX 230 236 {ECO:0000244|PDB:1XQ1}.
FT HELIX 239 241 {ECO:0000244|PDB:1XQ1}.
FT STRAND 248 250 {ECO:0000244|PDB:1XQ1}.
FT STRAND 255 257 {ECO:0000244|PDB:1XQ1}.
FT STRAND 260 262 {ECO:0000244|PDB:1XQ1}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 151 179 ipat:ADH_SHORT [T]
SQ SEQUENCE 266 AA; 28332 MW; 45F0CEE052D37559 CRC64;
MAGAEQSQRW SLKAKTVLVT GGTKGIGHAI VEEFAGFGAV IHTCARNEYE LNECLSKWQK
KGFQVTGSVC DASLRPEREK LMQTVSSMFG GKLDILINNL GAIRSKPTLD YTAEDFSFHI
STNLESAYHL SQLAHPLLKA SGCGNIIFMS SIAGVVSASV GSIYSATKGA LNQLARNLAC
EWASDGIRAN AVAPAVIATP LAEAVYDDEF KKVVISRKPL GRFGEPEEVS SLVAFLCMPA
ASYITGQTIC VDGGLTVNGF SYQPQG
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